Breast Cancer Profiling Project, Drug Sensitivity phase I: Fixed-cell GR measures of 35 breast cell lines to 34 small molecule perturbagens from library plate I. Dataset 2 of 2: Calculated dose response metrics - Dataset (ID:20344)

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Cell Small Molecule Primary Target Pathway GR50 GRmax GR_AOC Death_AUC GR Hill Coefficient GEC50 GR r2
BT-549 Alpelisib
PI3Ka
PI3K/mTOR
17.5141
 0.6841 0.0322 0.0099 1.0429
49.8384
0.95639
BT-549 Ipatasertib
AKT
PI3K/mTOR
12.6362
 0.4956 0.1735 0.0097 0.5079
1.6786
0.97652
BT-549 Taselisib
PI3Ka, g, d
PI3K/mTOR
2.2065
 0.0950 0.2229 0.0263 0.5717
15.0749
0.99278
BT-549 Olaparib
PARP
Misc
11.948
 0.5432 0.0657 0.0130 0.9548
37.7564
0.91931
BT-549 A-1210477
Mcl-1
Misc
Inf
 0.9540 0.0083 0.0018 0.0000
Inf
0.34182
BT-549 Volasertib
PLK
Cell cycle
0.0088352
 -0.2289 0.5676 0.1490 2.4967
0.0098732
0.99586
BT-549 Bleomycin
Radiation
Misc
0.17998
 -0.0141 0.4667 0.1506 1.0031
0.20287
0.99525
BT-549 TGX221
PI3Kb
PI3K/mTOR
Inf
 0.8097 0.0568 0.0017 0.6702
0.72927
0.89208
BT-549 Saracatinib
SRC
MAPK/nRTK
Inf
 0.5558 0.0348 0.0015 3.3790
3.6758
0.97565
BT-549 AZD7762
CHK1/2
Cell cycle
0.066029
 -0.4824 0.6356 0.2312 1.6999
0.087287
0.97383
BT-549 Palbociclib
CDK4/6
Cell cycle
Inf
 1.0500 -0.0401 -0.0011 0.0000
Inf
-9.2879
BT-549 Abemaciclib
CDK4/6
Cell cycle
3.9707
 0.0333 0.1267 0.0188 1.2825
7.5655
0.99654
BT-549 ABT-737
Bcl2/XL
Misc
Inf
 0.9359 -0.0225 0.0062 0.0000
Inf
0.067883
BT-549 Taxol
Chemo
Chemotherapy
0.0027257
 -0.2074 0.6989 0.2304 1.9420
0.0030953
0.98743
BT-549 Doxorubicin
Chemo
Chemotherapy
0.006482
 -0.3312 0.7603 0.1972 1.5744
0.0079126
0.9824
BT-549 Topotecan
Topo I
Chemotherapy
0.0084727
 -0.2410 0.8509 0.2269 1.4734
0.010061
0.9801
BT-549 Cisplatin
Chemo
Chemotherapy
1.016
 0.0674 0.2835 0.0552 1.0827
1.0937
0.98489
BT-549 Etoposide
Topo II
Chemotherapy
0.181
 -0.1948 0.4726 0.1408 1.1701
0.22766
0.99526
CAL-120 Abemaciclib
CDK4/6
Cell cycle
0.247
 -0.1408 0.4780 0.0849 0.3730
4.696
0.95026
CAL-120 Palbociclib
CDK4/6
Cell cycle
Inf
 0.6687 0.1422 0.0012 1.4451
0.023318
0.96675
CAL-120 AZD7762
CHK1/2
Cell cycle
0.15216
 -0.4949 0.5265 0.2150 1.1035
0.26511
0.97495
CAL-120 Volasertib
PLK
Cell cycle
0.0018536
 0.0258 0.6758 0.2649 2.5191
0.001844
0.99276
CAL-120 Dinaciclib
pan CDK
Cell cycle
0.009892
 -0.1320 0.5549 0.1203 4.4157
0.010404
0.99947
CAL-120 Doxorubicin
Chemo
Chemotherapy
0.009438
 -0.2475 0.6969 0.1356 1.3775
0.011488
0.99278
CAL-120 Cisplatin
Chemo
Chemotherapy
2.9328
 0.1876 0.1824 0.0229 0.9231
4.0426
0.98856