Breast Cancer Profiling Project, Drug Sensitivity phase I: Fixed-cell GR measures of 35 breast cell lines to 34 small molecule perturbagens from library plate I. Dataset 2 of 2: Calculated dose response metrics - Dataset (ID:20344)
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| Cell | Small Molecule | Primary Target | Pathway | GR50 | GRmax | GR_AOC | Death_AUC | GR Hill Coefficient | GEC50 | GR r2 |
|---|---|---|---|---|---|---|---|---|---|---|
| CAL-85-1 | A-1210477 | Mcl-1 | Misc | Inf | 1.0052 | 0.0109 | 0.0047 | 0.0000 | Inf | 0.20764 |
| SUM1315MO2 | A-1210477 | Mcl-1 | Misc | Inf | 0.7399 | -0.0234 | -0.0009 | 3.9393 | 9.1387 | 0.79269 |
| MDA-MB-468 | A-1210477 | Mcl-1 | Misc | Inf | 0.9299 | 0.0206 | 0.0057 | 0.3898 | 963.6809 | 0.60314 |
| HCC1428 | A-1210477 | Mcl-1 | Misc | Inf | 0.8155 | -0.0207 | 0.0026 | 4.9615 | 5.2131 | 0.71606 |
| MDA-MB-134-VI | A-1210477 | Mcl-1 | Misc | Inf | 1.0500 | -0.0366 | -0.0033 | 0.0000 | Inf | -3.0589 |
| MDA-MB-157 | A-1210477 | Mcl-1 | Misc | 13.1155 | 0.7884 | 0.0063 | 0.0017 | 4.9648 | 12.9049 | 0.88212 |
| SK-BR-3 | A-1210477 | Mcl-1 | Misc | 11.3859 | 0.6275 | 0.0389 | 0.0040 | 4.3303 | 10.9082 | 0.92796 |
| T47D | A-1210477 | Mcl-1 | Misc | Inf | 0.5752 | 0.0227 | 0.0055 | 5.0000 | 3.7781 | 0.96287 |
| MCF 10A | A-1210477 | Mcl-1 | Misc | Inf | 0.9527 | 0.0018 | 0.0006 | 4.5125 | 3.8181 | 0.94609 |
| CAL-120 | A-1210477 | Mcl-1 | Misc | Inf | 0.9427 | 0.0152 | 0.0003 | 0.0000 | Inf | 0.34764 |
| HCC1143 | A-1210477 | Mcl-1 | Misc | 16.3987 | 0.6719 | 0.0640 | 0.0008 | 1.0821 | 44.847 | 0.81227 |
| MDA-MB-361 | A-1210477 | Mcl-1 | Misc | Inf | 0.9850 | -0.0083 | 0.0037 | 0.0000 | Inf | -0.045307 |
| Hs 578T | A-1210477 | Mcl-1 | Misc | Inf | 0.9419 | -0.0065 | -0.0001 | 0.0000 | Inf | 0.41975 |
| PDX1328 | A-1210477 | Mcl-1 | Misc | 29.0724 | 0.7094 | 0.0609 | 0.0135 | 0.6451 | 128.4233 | 0.82503 |
| HCC1419 | A-1210477 | Mcl-1 | Misc | 14.536 | 0.7081 | 0.0402 | 0.0018 | 1.8053 | 26.3399 | 0.8672 |