Breast Cancer Profiling Project, Drug Sensitivity phase I: Fixed-cell GR measures of 35 breast cell lines to 34 small molecule perturbagens from library plate I. Dataset 2 of 2: Calculated dose response metrics - Dataset (ID:20344)

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Cell Small Molecule Primary Target Pathway GR50 GRmax GR_AOC Death_AUC GR Hill Coefficient GEC50 GR r2
Hs 578T Topotecan
Topo I
Chemotherapy
0.0049855
 -0.4488 1.0175 0.4717 1.1814
0.0076404
0.9429
MDA-MB-453 Taselisib
PI3Ka, g, d
PI3K/mTOR
0.0034639
 -0.6347 1.0079 0.2403 0.8199
0.0064512
0.90769
MDA-MB-468 Taxol
Chemo
Chemotherapy
0.001354
 -0.5218 1.0076 0.5243 1.2795
0.0023644
0.95471
HCC1419 Neratinib
EGFR/HER2
RTK
0.0011485
 -0.5015 0.9927 0.1818 0.5367
0.0038194
0.97246
HCC1419 Topotecan
Topo I
Chemotherapy
0.0071886
 -0.7857 0.9904 0.1711 0.4002
0.11192
0.94532
BT-20 Taxol
Chemo
Chemotherapy
0.0020158
 -0.5760 0.9854 0.4456 2.0677
0.0028795
0.99355
MDA-MB-157 AZD7762
CHK1/2
Cell cycle
0.015418
 -0.7858 0.9840 0.3122 0.8223
0.045445
0.98837
MDA-MB-361 Luminespib
HSP90
Misc
0.0071417
 -0.8855 0.9781 0.3455 4.9987
0.0087421
0.9995
HCC70 Taxol
Chemo
Chemotherapy
0.0013411
 -0.5065 0.9773 0.3742 1.1642
0.0024269
0.99734
MDA-MB-361 Taxol
Chemo
Chemotherapy
0.0031082
 -0.6090 0.9738 0.2561 2.5508
0.0042111
0.9201
SK-BR-3 INK-128
mTORC1/2
PI3K/mTOR
0.0026508
 -0.5064 0.9712 0.2693 1.0983
0.0044617
0.98817
PDX1328 Volasertib
PLK
Cell cycle
0.0025124
 -0.5731 0.9694 0.2182 2.8453
0.0032751
0.99856
PDXHCI002 Doxorubicin
Chemo
Chemotherapy
0.0040539
 -0.6545 0.9685 0.2951 0.9297
0.0087544
0.98094
MDA-MB-157 Doxorubicin
Chemo
Chemotherapy
0.0032329
 -0.7766 0.9661 0.1885 0.9535
0.006701
0.93404
T47D Topotecan
Topo I
Chemotherapy
0.0052275
 -0.1971 0.9594 0.1261 1.3094
0.0068541
0.99083
Hs 578T Taxol
Chemo
Chemotherapy
0.0010154
 -0.3752 0.9535 0.4788 1.2811
0.0015458
0.95438
CAMA-1 Taxol
Chemo
Chemotherapy
0.0022699
 -0.4944 0.9525 0.3547 2.4920
0.0029769
0.99478
HCC1954 Taselisib
PI3Ka, g, d
PI3K/mTOR
0.0070107
 -0.3632 0.9490 0.3748 1.0954
0.010784
0.99379
MDA-MB-157 Taxol
Chemo
Chemotherapy
0.002046
 -0.6700 0.9482 0.3487 1.9966
0.0029397
0.97064
MDA-MB-134-VI Luminespib
HSP90
Misc
0.0047553
 -0.7660 0.9424 0.2076 3.5318
0.006139
0.99851
SK-BR-3 Doxorubicin
Chemo
Chemotherapy
0.0067336
 -0.6156 0.9421 0.3142 1.5278
0.010801
0.99572
SUM149PT Topotecan
Topo I
Chemotherapy
0.0056894
 -0.4596 0.9408 0.4257 1.0455
0.0084398
0.94
MDA-MB-468 Volasertib
PLK
Cell cycle
0.002104
 -0.4485 0.9279 0.3934 2.9173
0.0026072
0.99938
MDA-MB-453 Topotecan
Topo I
Chemotherapy
0.0066897
 -0.5289 0.9258 0.1604 1.0131
0.010358
0.92364
HCC1500 Dasatinib
BCR/ABL
MAPK/nRTK
0.0034818
 -0.1594 0.9249 0.0829 0.7537
0.0052374
0.99634