Breast Cancer Profiling Project, Drug Sensitivity phase I: Fixed-cell GR measures of 35 breast cell lines to 34 small molecule perturbagens from library plate I. Dataset 1 of 2: Normalized growth rate inhibition values - Dataset (ID:20343)

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Cell Small Molecule Small Mol Concentration (uM) Primary Target Pathway Mean Normalized Growth Rate Inhibition Value Increased Fraction Dead
PDX1328 Tivantinib
0.0031623
MET
RTK
 1.1499 0.00008
HCC1500 Ipatasertib
0.01
AKT
PI3K/mTOR
 1.1500 0.00530
HCC1806 PF-4708671
3.1623
p70S6K
PI3K/mTOR
 1.1503 -0.01604
HCC1954 Cabozantinib
0.31623
VEGFR2/MET
RTK
 1.1505 -0.01637
PDX1328 Ceritinib
0.0031623
ALK
RTK
 1.1506 0.00069
PDX1328 Olaparib
0.0031623
PARP
Misc
 1.1511 -0.01286
MDA-MB-453 Vorinostat
0.031623
HDAC
Misc
 1.1522 0.02043
HCC70 Ceritinib
0.0031623
ALK
RTK
 1.1527 0.00335
HCC1500 Buparlisib
0.001
pan PI3K
PI3K/mTOR
 1.1529 0.00448
MDA-MB-453 Cabozantinib
0.001
VEGFR2/MET
RTK
 1.1531 0.01205
T47D Vorinostat
0.31623
HDAC
Misc
 1.1532 0.00107
HCC1419 Ipatasertib
0.01
AKT
PI3K/mTOR
 1.1535 -0.00296
SK-BR-3 Cabozantinib
0.1
VEGFR2/MET
RTK
 1.1537 -0.00868
MDA-MB-453 PF-4708671
0.1
p70S6K
PI3K/mTOR
 1.1545 0.00404
MDA-MB-134-VI Olaparib
0.1
PARP
Misc
 1.1545 -0.00224
MDA-MB-134-VI PF-4708671
0.031623
p70S6K
PI3K/mTOR
 1.1546 -0.00330
MDA-MB-453 Saracatinib
0.0031623
SRC
MAPK/nRTK
 1.1549 0.00509
HCC70 Luminespib
0.0001
HSP90
Misc
 1.1557 0.00993
PDX1258 AZD7762
0.001
CHK1/2
Cell cycle
 1.1558 0.00421
SK-BR-3 Saracatinib
0.31623
SRC
MAPK/nRTK
 1.1562 -0.00826
MDA-MB-361 TGX221
0.031623
PI3Kb
PI3K/mTOR
 1.1566 -0.00358
HCC70 Luminespib
0.001
HSP90
Misc
 1.1566 0.00882
HCC70 Abemaciclib
0.031623
CDK4/6
Cell cycle
 1.1572 -0.01029
MDA-MB-361 Volasertib
0.001
PLK
Cell cycle
 1.1573 0.00001
CAMA-1 Cisplatin
0.0010833
Chemo
Chemotherapy
 1.1581 -0.00442