Breast Cancer Profiling Project, Drug Sensitivity phase I: Fixed-cell GR measures of 35 breast cell lines to 34 small molecule perturbagens from library plate I. Dataset 1 of 2: Normalized growth rate inhibition values - Dataset (ID:20343)
Download: Excel (XLSX), Comma-separated (CSV)
| Cell | Small Molecule | Small Mol Concentration (uM) | Primary Target | Pathway | Mean Normalized Growth Rate Inhibition Value | Increased Fraction Dead |
|---|---|---|---|---|---|---|
| HCC1500 | Etoposide | 0.031667 | Topo II | Chemotherapy | 1.2999 | -0.03422 |
| MDA-MB-453 | Bleomycin | 0.0033333 | Radiation | Misc | 1.1385 | -0.03404 |
| CAL-51 | Abemaciclib | 0.1 | CDK4/6 | Cell cycle | 0.4945 | -0.03320 |
| PDXHCI002 | Abemaciclib | 0.01 | CDK4/6 | Cell cycle | 0.7972 | -0.03263 |
| MDA-MB-134-VI | Palbociclib | 0.31623 | CDK4/6 | Cell cycle | 0.1987 | -0.03194 |
| CAL-51 | Abemaciclib | 0.01 | CDK4/6 | Cell cycle | 0.7326 | -0.03173 |
| MDA-MB-134-VI | Abemaciclib | 0.0031623 | CDK4/6 | Cell cycle | 0.3392 | -0.03121 |
| PDXHCI002 | Bleomycin | 0.031667 | Radiation | Misc | 0.9519 | -0.03029 |
| HCC1500 | Bleomycin | 1.0 | Radiation | Misc | 0.7356 | -0.03001 |
| HCC1500 | Abemaciclib | 3.1623 | CDK4/6 | Cell cycle | 0.4416 | -0.02996 |
| HCC1500 | Bleomycin | 0.0010833 | Radiation | Misc | 0.9717 | -0.02967 |
| MDA-MB-453 | Etoposide | 0.0010833 | Topo II | Chemotherapy | 1.0751 | -0.02866 |
| CAL-51 | Palbociclib | 3.1623 | CDK4/6 | Cell cycle | 0.3607 | -0.02855 |
| HCC1954 | Cabozantinib | 1.0 | VEGFR2/MET | RTK | 1.2542 | -0.02847 |
| CAL-51 | Abemaciclib | 0.31623 | CDK4/6 | Cell cycle | 0.3646 | -0.02833 |
| HCC1500 | Cisplatin | 1.0 | Chemo | Chemotherapy | 1.0851 | -0.02824 |
| HCC1954 | Cabozantinib | 0.1 | VEGFR2/MET | RTK | 1.1347 | -0.02794 |
| CAL-51 | Palbociclib | 0.031623 | CDK4/6 | Cell cycle | 0.7835 | -0.02787 |
| MDA-MB-453 | Cisplatin | 0.031667 | Chemo | Chemotherapy | 1.1406 | -0.02765 |
| PDXHCI002 | Bleomycin | 0.01 | Radiation | Misc | 1.0386 | -0.02725 |
| PDXHCI002 | Abemaciclib | 0.031623 | CDK4/6 | Cell cycle | 0.5157 | -0.02723 |
| PDXHCI002 | Etoposide | 0.0033333 | Topo II | Chemotherapy | 0.9115 | -0.02699 |
| HCC1500 | Etoposide | 0.01 | Topo II | Chemotherapy | 0.9884 | -0.02674 |
| MDA-MB-134-VI | Abemaciclib | 0.1 | CDK4/6 | Cell cycle | 0.4755 | -0.02664 |
| PDXHCI002 | Abemaciclib | 0.0031623 | CDK4/6 | Cell cycle | 1.0168 | -0.02663 |