Breast Cancer Profiling Project, Drug Sensitivity phase I: Fixed-cell GR measures of 35 breast cell lines to 34 small molecule perturbagens from library plate I. Dataset 1 of 2: Normalized growth rate inhibition values - Dataset (ID:20343)

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Cell Small Molecule Small Mol Concentration (uM) Primary Target Pathway Mean Normalized Growth Rate Inhibition Value Increased Fraction Dead
PDXHCI002 INK-128
1.0
mTORC1/2
PI3K/mTOR
 0.3512 -0.04857
PDXHCI002 Everolimus
10.0
mTOR1
PI3K/mTOR
 0.9869 -0.04768
PDXHCI002 Everolimus
0.01
mTOR1
PI3K/mTOR
 1.1376 -0.04754
PDXHCI002 Everolimus
3.1623
mTOR1
PI3K/mTOR
 1.0442 -0.04734
PDXHCI002 Everolimus
0.0031623
mTOR1
PI3K/mTOR
 1.0799 -0.04679
PDXHCI002 Bleomycin
0.1
Radiation
Misc
 0.9239 -0.04511
HCC1500 Bleomycin
0.1
Radiation
Misc
 0.9640 -0.04452
PDXHCI002 Everolimus
1.0
mTOR1
PI3K/mTOR
 1.0816 -0.04413
HCC1500 Etoposide
0.1
Topo II
Chemotherapy
 0.9982 -0.04393
PDXHCI002 Everolimus
0.001
mTOR1
PI3K/mTOR
 1.1106 -0.04384
HCC1500 Topotecan
0.0010833
Topo I
Chemotherapy
 0.7407 -0.04357
HCC1500 Topotecan
0.01
Topo I
Chemotherapy
 0.3779 -0.04351
MDA-MB-134-VI Abemaciclib
0.31623
CDK4/6
Cell cycle
 0.7639 -0.04308
MDA-MB-453 Cisplatin
1.0
Chemo
Chemotherapy
 0.9696 -0.04139
PDXHCI002 Etoposide
0.0010833
Topo II
Chemotherapy
 1.0798 -0.04076
HCC1500 Bleomycin
0.01
Radiation
Misc
 1.0429 -0.04012
PDXHCI002 Topotecan
0.1
Topo I
Chemotherapy
 -0.1014 -0.03893
PDXHCI002 Torin2
0.1
mTOR/ATM/ATR
PI3K/mTOR
 0.4925 -0.03840
CAL-51 Palbociclib
1.0
CDK4/6
Cell cycle
 0.4516 -0.03770
CAL-51 Palbociclib
0.31623
CDK4/6
Cell cycle
 0.5284 -0.03729
CAL-51 Palbociclib
0.1
CDK4/6
Cell cycle
 0.6466 -0.03669
PDXHCI002 Torin2
0.0031623
mTOR/ATM/ATR
PI3K/mTOR
 1.3716 -0.03537
PDXHCI002 INK-128
0.0031623
mTORC1/2
PI3K/mTOR
 1.4120 -0.03534
PDXHCI002 Ipatasertib
10.0
AKT
PI3K/mTOR
 1.0989 -0.03489
CAL-51 Abemaciclib
0.031623
CDK4/6
Cell cycle
 0.5674 -0.03450