Breast Cancer Profiling Project, Drug Sensitivity phase I: Fixed-cell GR measures of 35 breast cell lines to 34 small molecule perturbagens from library plate I. Dataset 1 of 2: Normalized growth rate inhibition values - Dataset (ID:20343)
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| Cell | Small Molecule | Small Mol Concentration (uM) | Primary Target | Pathway | Mean Normalized Growth Rate Inhibition Value | Increased Fraction Dead |
|---|---|---|---|---|---|---|
| PDX1328 | AZD7762 | 0.01 | CHK1/2 | Cell cycle | 1.2041 | 0.00368 |
| PDX1328 | Palbociclib | 1.0 | CDK4/6 | Cell cycle | 0.1110 | 0.00478 |
| PDX1328 | Abemaciclib | 10.0 | CDK4/6 | Cell cycle | -0.7514 | 0.53932 |
| PDX1328 | Palbociclib | 0.1 | CDK4/6 | Cell cycle | 0.3452 | 0.01100 |
| PDX1328 | Abemaciclib | 0.1 | CDK4/6 | Cell cycle | 0.1548 | 0.02050 |
| MCF 10A | Dinaciclib | 0.31623 | pan CDK | Cell cycle | -0.2300 | 0.54464 |
| BT-20 | Dinaciclib | 0.031623 | pan CDK | Cell cycle | -0.2318 | 0.45734 |
| BT-20 | Dinaciclib | 0.0001 | pan CDK | Cell cycle | 0.9253 | 0.00567 |
| MCF7 | Palbociclib | 1.0 | CDK4/6 | Cell cycle | 0.2988 | 0.03512 |
| MDA-MB-468 | AZD7762 | 0.031623 | CHK1/2 | Cell cycle | 0.9701 | 0.06287 |