Breast Cancer Profiling Project, Drug Sensitivity phase I: Fixed-cell GR measures of 35 breast cell lines to 34 small molecule perturbagens from library plate I. Dataset 1 of 2: Normalized growth rate inhibition values - Dataset (ID:20343)

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Cell Small Molecule Small Mol Concentration (uM) Primary Target Pathway Mean Normalized Growth Rate Inhibition Value Increased Fraction Dead
T47D AZD7762
0.01
CHK1/2
Cell cycle
 1.3830 -0.00136
PDXHCI002 Torin2
0.0031623
mTOR/ATM/ATR
PI3K/mTOR
 1.3716 -0.03537
HCC70 AZD7762
0.0031623
CHK1/2
Cell cycle
 1.3706 -0.00299
MDA-MB-134-VI Cabozantinib
1.0
VEGFR2/MET
RTK
 1.3646 -0.00006
MDA-MB-134-VI Neratinib
0.001
EGFR/HER2
RTK
 1.3618 -0.00624
CAL-85-1 AZD7762
0.0031623
CHK1/2
Cell cycle
 1.3608 -0.00028
MDA-MB-134-VI Cabozantinib
0.001
VEGFR2/MET
RTK
 1.3562 -0.00502
MDA-MB-134-VI Luminespib
0.0001
HSP90
Misc
 1.3453 -0.00808
MDA-MB-134-VI PF-4708671
0.01
p70S6K
PI3K/mTOR
 1.3419 -0.00121
HCC1419 Volasertib
0.00031623
PLK
Cell cycle
 1.3365 0.00331
MDA-MB-134-VI Luminespib
0.00031623
HSP90
Misc
 1.3361 -0.01039
MDA-MB-134-VI Neratinib
0.00031623
EGFR/HER2
RTK
 1.3354 0.00352
PDXHCI002 INK-128
0.01
mTORC1/2
PI3K/mTOR
 1.3353 -0.05354
MDA-MB-134-VI Cediranib
0.0031623
VEGFR/cKIT
RTK
 1.3300 -0.00799
MDA-MB-134-VI Vorinostat
0.31623
HDAC
Misc
 1.3286 0.00076
HCC70 Abemaciclib
0.0031623
CDK4/6
Cell cycle
 1.3213 -0.01140
MDA-MB-134-VI Cediranib
1.0
VEGFR/cKIT
RTK
 1.3176 0.01247
MDA-MB-134-VI Alpelisib
0.0031623
PI3Ka
PI3K/mTOR
 1.3174 -0.00250
MDA-MB-134-VI Cediranib
0.001
VEGFR/cKIT
RTK
 1.3158 -0.01192
HCC1419 Vorinostat
0.31623
HDAC
Misc
 1.3152 -0.00210
HCC70 Volasertib
0.00031623
PLK
Cell cycle
 1.3093 0.00186
MDA-MB-453 Vorinostat
0.31623
HDAC
Misc
 1.3002 0.00416
HCC1500 Etoposide
0.031667
Topo II
Chemotherapy
 1.2999 -0.03422
MDA-MB-453 Ipatasertib
0.01
AKT
PI3K/mTOR
 1.2982 -0.02244
T47D AZD7762
0.1
CHK1/2
Cell cycle
 1.2980 0.00257