Breast Cancer Profiling Project, Drug Sensitivity phase I: Fixed-cell GR measures of 35 breast cell lines to 34 small molecule perturbagens from library plate I. Dataset 1 of 2: Normalized growth rate inhibition values - Dataset (ID:20343)
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| Cell | Small Molecule | Small Mol Concentration (uM) | Primary Target | Pathway | Mean Normalized Growth Rate Inhibition Value | Increased Fraction Dead |
|---|---|---|---|---|---|---|
| BT-20 | PF-4708671 | 0.31623 | p70S6K | PI3K/mTOR | 1.0005 | 0.00873 |
| BT-20 | PF-4708671 | 1.0 | p70S6K | PI3K/mTOR | 0.9309 | 0.01200 |
| BT-20 | PF-4708671 | 3.1623 | p70S6K | PI3K/mTOR | 0.9194 | 0.01681 |
| BT-20 | PF-4708671 | 10.0 | p70S6K | PI3K/mTOR | 0.6601 | 0.04619 |
| BT-20 | Buparlisib | 0.001 | pan PI3K | PI3K/mTOR | 1.0970 | 0.00090 |
| BT-20 | Buparlisib | 0.0031623 | pan PI3K | PI3K/mTOR | 1.0712 | -0.00362 |
| BT-20 | Buparlisib | 0.01 | pan PI3K | PI3K/mTOR | 1.0597 | 0.00288 |
| BT-20 | Buparlisib | 0.031623 | pan PI3K | PI3K/mTOR | 1.0280 | -0.00097 |
| BT-20 | Buparlisib | 0.1 | pan PI3K | PI3K/mTOR | 0.8718 | 0.01650 |
| BT-20 | Buparlisib | 0.31623 | pan PI3K | PI3K/mTOR | 0.7839 | 0.02546 |
| BT-20 | Buparlisib | 1.0 | pan PI3K | PI3K/mTOR | 0.2586 | 0.12379 |
| BT-20 | Buparlisib | 3.1623 | pan PI3K | PI3K/mTOR | -0.2213 | 0.44934 |
| BT-20 | Buparlisib | 10.0 | pan PI3K | PI3K/mTOR | -0.5514 | 0.71187 |
| BT-20 | Pictilisib | 0.001 | pan PI3K | PI3K/mTOR | 0.9230 | 0.00165 |
| BT-20 | Pictilisib | 0.0031623 | pan PI3K | PI3K/mTOR | 1.0475 | -0.00034 |
| BT-20 | Pictilisib | 0.01 | pan PI3K | PI3K/mTOR | 1.0160 | 0.00276 |
| BT-20 | Pictilisib | 0.031623 | pan PI3K | PI3K/mTOR | 0.9225 | 0.00683 |
| BT-20 | Pictilisib | 0.1 | pan PI3K | PI3K/mTOR | 0.9192 | 0.00931 |
| BT-20 | Pictilisib | 0.31623 | pan PI3K | PI3K/mTOR | 0.7890 | 0.02029 |
| BT-20 | Pictilisib | 1.0 | pan PI3K | PI3K/mTOR | 0.4469 | 0.06426 |
| BT-20 | Pictilisib | 3.1623 | pan PI3K | PI3K/mTOR | 0.1117 | 0.17104 |
| BT-20 | Pictilisib | 10.0 | pan PI3K | PI3K/mTOR | -0.1650 | 0.38649 |
| BT-20 | Ceritinib | 0.001 | ALK | RTK | 1.0413 | -0.00151 |
| BT-20 | Ceritinib | 0.0031623 | ALK | RTK | 1.0478 | -0.00217 |
| BT-20 | Ceritinib | 0.01 | ALK | RTK | 1.0693 | -0.00162 |