Breast Cancer Profiling Project, Drug Sensitivity phase I: Fixed-cell GR measures of 35 breast cell lines to 34 small molecule perturbagens from library plate I. Dataset 1 of 2: Normalized growth rate inhibition values - Dataset (ID:20343)

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Cell Small Molecule Small Mol Concentration (uM) Primary Target Pathway Mean Normalized Growth Rate Inhibition Value Increased Fraction Dead
SK-BR-3 AZD7762
0.01
CHK1/2
Cell cycle
 0.9248 0.08349
SK-BR-3 AZD7762
0.031623
CHK1/2
Cell cycle
 0.0327 0.33600
SK-BR-3 AZD7762
0.1
CHK1/2
Cell cycle
 -0.3118 0.41140
SK-BR-3 AZD7762
0.31623
CHK1/2
Cell cycle
 -0.3571 0.41177
SK-BR-3 AZD7762
1.0
CHK1/2
Cell cycle
 -0.4093 0.41557
SK-BR-3 AZD7762
3.1623
CHK1/2
Cell cycle
 -0.4470 0.44511
SK-BR-3 AZD7762
10.0
CHK1/2
Cell cycle
 -0.4509 0.45826
SK-BR-3 Volasertib
0.0001
PLK
Cell cycle
 1.0320 -0.00050
SK-BR-3 Volasertib
0.00031623
PLK
Cell cycle
 1.0373 0.00381
SK-BR-3 Volasertib
0.001
PLK
Cell cycle
 1.1369 -0.00599
SK-BR-3 Volasertib
0.0031623
PLK
Cell cycle
 0.9176 0.02544
SK-BR-3 Volasertib
0.01
PLK
Cell cycle
 -0.1470 0.43910
SK-BR-3 Volasertib
0.031623
PLK
Cell cycle
 -0.2769 0.50115
SK-BR-3 Volasertib
0.1
PLK
Cell cycle
 -0.2755 0.51415
SK-BR-3 Volasertib
0.31623
PLK
Cell cycle
 -0.2822 0.51136
SK-BR-3 Volasertib
1.0
PLK
Cell cycle
 -0.3494 0.53084
SK-BR-3 Dinaciclib
0.0001
pan CDK
Cell cycle
 0.9624 0.01103
SK-BR-3 Dinaciclib
0.00031623
pan CDK
Cell cycle
 0.9306 0.01067
SK-BR-3 Dinaciclib
0.001
pan CDK
Cell cycle
 1.0579 0.00895
SK-BR-3 Dinaciclib
0.0031623
pan CDK
Cell cycle
 0.9472 0.01034
SK-BR-3 Dinaciclib
0.01
pan CDK
Cell cycle
 -0.0065 0.29806
SK-BR-3 Dinaciclib
0.031623
pan CDK
Cell cycle
 -0.5830 0.57124
SK-BR-3 Dinaciclib
0.1
pan CDK
Cell cycle
 -0.5968 0.60052
SK-BR-3 Dinaciclib
0.31623
pan CDK
Cell cycle
 -0.6209 0.61399
SK-BR-3 Dinaciclib
1.0
pan CDK
Cell cycle
 -0.5821 0.58342