Breast Cancer Profiling Project, Drug Sensitivity phase I: Fixed-cell GR measures of 35 breast cell lines to 34 small molecule perturbagens from library plate I. Dataset 1 of 2: Normalized growth rate inhibition values - Dataset (ID:20343)

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Cell Small Molecule Small Mol Concentration (uM) Primary Target Pathway Mean Normalized Growth Rate Inhibition Value Increased Fraction Dead
SUM149PT Vorinostat
1.0
HDAC
Misc
 0.6182 0.01932
SUM149PT Vorinostat
3.1623
HDAC
Misc
 0.1607 0.09583
SUM149PT Vorinostat
10.0
HDAC
Misc
 -0.0716 0.25413
SUM149PT Luminespib
0.0001
HSP90
Misc
 1.0366 0.00300
SUM149PT Luminespib
0.00031623
HSP90
Misc
 1.0068 0.00027
SUM149PT Luminespib
0.001
HSP90
Misc
 1.0038 -0.00206
SUM149PT Luminespib
0.0031623
HSP90
Misc
 0.8106 0.00826
SUM149PT Luminespib
0.01
HSP90
Misc
 -0.0671 0.45246
SUM149PT Luminespib
0.031623
HSP90
Misc
 -0.3697 0.68596
SUM149PT Luminespib
0.1
HSP90
Misc
 -0.3767 0.68080
SUM149PT Luminespib
0.31623
HSP90
Misc
 -0.3744 0.67001
SUM149PT Luminespib
1.0
HSP90
Misc
 -0.3912 0.70780
SUM149PT A-1210477
0.001
Mcl-1
Misc
 1.0116 -0.00038
SUM149PT A-1210477
0.0031623
Mcl-1
Misc
 1.0503 0.00525
SUM149PT A-1210477
0.01
Mcl-1
Misc
 1.0124 0.00033
SUM149PT A-1210477
0.031623
Mcl-1
Misc
 1.0141 -0.00086
SUM149PT A-1210477
0.1
Mcl-1
Misc
 1.0157 0.00096
SUM149PT A-1210477
0.31623
Mcl-1
Misc
 1.0041 -0.00022
SUM149PT A-1210477
1.0
Mcl-1
Misc
 0.9991 -0.00004
SUM149PT A-1210477
3.1623
Mcl-1
Misc
 0.8943 0.02529
SUM149PT A-1210477
10.0
Mcl-1
Misc
 0.3670 0.16070
SUM149PT Olaparib
0.001
PARP
Misc
 0.9840 0.00128
SUM149PT Olaparib
0.0031623
PARP
Misc
 0.9688 0.00254
SUM149PT Olaparib
0.01
PARP
Misc
 0.9280 0.00735
SUM149PT Olaparib
0.031623
PARP
Misc
 0.9152 0.01386