Breast Cancer Profiling Project, Drug Sensitivity phase I: Fixed-cell GR measures of 35 breast cell lines to 34 small molecule perturbagens from library plate I. Dataset 1 of 2: Normalized growth rate inhibition values - Dataset (ID:20343)

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Cell Small Molecule Small Mol Concentration (uM) Primary Target Pathway Mean Normalized Growth Rate Inhibition Value Increased Fraction Dead
SUM149PT Abemaciclib
3.1623
CDK4/6
Cell cycle
 0.3853 0.00345
SUM149PT Abemaciclib
10.0
CDK4/6
Cell cycle
 0.0949 0.13178
SUM149PT Palbociclib
0.00031623
CDK4/6
Cell cycle
 1.0164 0.00407
SUM149PT Palbociclib
0.001
CDK4/6
Cell cycle
 1.0332 0.00129
SUM149PT Palbociclib
0.0031623
CDK4/6
Cell cycle
 1.0082 0.00197
SUM149PT Palbociclib
0.01
CDK4/6
Cell cycle
 0.9709 -0.00315
SUM149PT Palbociclib
0.031623
CDK4/6
Cell cycle
 0.8233 -0.00213
SUM149PT Palbociclib
0.1
CDK4/6
Cell cycle
 0.7190 -0.00034
SUM149PT Palbociclib
0.31623
CDK4/6
Cell cycle
 0.6048 -0.00137
SUM149PT Palbociclib
1.0
CDK4/6
Cell cycle
 0.5654 0.00397
SUM149PT Palbociclib
3.1623
CDK4/6
Cell cycle
 0.4873 0.00879
SUM149PT AZD7762
0.001
CHK1/2
Cell cycle
 1.0174 0.00415
SUM149PT AZD7762
0.0031623
CHK1/2
Cell cycle
 1.0674 -0.00114
SUM149PT AZD7762
0.01
CHK1/2
Cell cycle
 1.1034 0.00450
SUM149PT AZD7762
0.031623
CHK1/2
Cell cycle
 0.9577 0.04259
SUM149PT AZD7762
0.1
CHK1/2
Cell cycle
 0.2671 0.28901
SUM149PT AZD7762
0.31623
CHK1/2
Cell cycle
 -0.1824 0.54447
SUM149PT AZD7762
1.0
CHK1/2
Cell cycle
 -0.3596 0.65729
SUM149PT AZD7762
3.1623
CHK1/2
Cell cycle
 -0.3899 0.67425
SUM149PT AZD7762
10.0
CHK1/2
Cell cycle
 -0.4731 0.71544
SUM149PT Volasertib
0.0001
PLK
Cell cycle
 1.0248 0.00343
SUM149PT Volasertib
0.00031623
PLK
Cell cycle
 1.0403 0.00326
SUM149PT Volasertib
0.001
PLK
Cell cycle
 1.0419 0.00201
SUM149PT Volasertib
0.0031623
PLK
Cell cycle
 0.9796 0.01261
SUM149PT Volasertib
0.01
PLK
Cell cycle
 0.6221 0.09640