Breast Cancer Profiling Project, Drug Sensitivity phase I: Fixed-cell GR measures of 35 breast cell lines to 34 small molecule perturbagens from library plate I. Dataset 1 of 2: Normalized growth rate inhibition values - Dataset (ID:20343)
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| Cell | Small Molecule | Small Mol Concentration (uM) | Primary Target | Pathway | Mean Normalized Growth Rate Inhibition Value | Increased Fraction Dead |
|---|---|---|---|---|---|---|
| PDXHCI002 | Dinaciclib | 0.001 | pan CDK | Cell cycle | 1.1022 | -0.00350 |
| PDXHCI002 | Dinaciclib | 0.0031623 | pan CDK | Cell cycle | 1.0541 | -0.00394 |
| PDXHCI002 | Dinaciclib | 0.01 | pan CDK | Cell cycle | 0.7430 | -0.00330 |
| PDXHCI002 | Dinaciclib | 0.031623 | pan CDK | Cell cycle | -0.3315 | 0.45230 |
| PDXHCI002 | Dinaciclib | 0.1 | pan CDK | Cell cycle | -0.3866 | 0.51109 |
| PDXHCI002 | Dinaciclib | 0.31623 | pan CDK | Cell cycle | -0.3435 | 0.44907 |
| PDXHCI002 | Dinaciclib | 1.0 | pan CDK | Cell cycle | -0.3607 | 0.43873 |
| PDXHCI002 | Cisplatin | 0.0010833 | Chemo | Chemotherapy | 1.0979 | -0.01474 |
| PDXHCI002 | Cisplatin | 0.0033333 | Chemo | Chemotherapy | 1.0558 | -0.01581 |
| PDXHCI002 | Cisplatin | 0.01 | Chemo | Chemotherapy | 0.9300 | 0.00330 |
| PDXHCI002 | Cisplatin | 0.031667 | Chemo | Chemotherapy | 0.9999 | 0.00348 |
| PDXHCI002 | Cisplatin | 0.1 | Chemo | Chemotherapy | 1.0456 | -0.02549 |
| PDXHCI002 | Cisplatin | 0.31623 | Chemo | Chemotherapy | 0.9496 | -0.05460 |
| PDXHCI002 | Cisplatin | 1.0 | Chemo | Chemotherapy | 0.6445 | -0.07108 |
| PDXHCI002 | Cisplatin | 3.1623 | Chemo | Chemotherapy | 0.2841 | -0.09181 |
| PDXHCI002 | Cisplatin | 10.0 | Chemo | Chemotherapy | -0.0985 | 0.03568 |
| PDXHCI002 | Doxorubicin | 0.00031623 | Chemo | Chemotherapy | 0.9248 | 0.00034 |
| PDXHCI002 | Doxorubicin | 0.001 | Chemo | Chemotherapy | 0.8342 | 0.00326 |
| PDXHCI002 | Doxorubicin | 0.0031623 | Chemo | Chemotherapy | 0.6241 | 0.02101 |
| PDXHCI002 | Doxorubicin | 0.01 | Chemo | Chemotherapy | 0.1278 | 0.14173 |
| PDXHCI002 | Doxorubicin | 0.031623 | Chemo | Chemotherapy | -0.1966 | 0.24248 |
| PDXHCI002 | Doxorubicin | 0.1 | Chemo | Chemotherapy | -0.2421 | 0.27844 |
| PDXHCI002 | Doxorubicin | 0.31623 | Chemo | Chemotherapy | -0.4831 | 0.56087 |
| PDXHCI002 | Doxorubicin | 1.0 | Chemo | Chemotherapy | -0.6545 | 0.80551 |
| PDXHCI002 | Doxorubicin | 3.1623 | Chemo | Chemotherapy | -0.4401 | 0.60190 |