Breast Cancer Profiling Project, Drug Sensitivity phase I: Fixed-cell GR measures of 35 breast cell lines to 34 small molecule perturbagens from library plate I. Dataset 1 of 2: Normalized growth rate inhibition values - Dataset (ID:20343)
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| Cell | Small Molecule | Small Mol Concentration (uM) | Primary Target | Pathway | Mean Normalized Growth Rate Inhibition Value | Increased Fraction Dead |
|---|---|---|---|---|---|---|
| CAL-85-1 | AZD7762 | 3.1623 | CHK1/2 | Cell cycle | -0.3218 | 0.48349 |
| CAL-85-1 | AZD7762 | 10.0 | CHK1/2 | Cell cycle | -0.2971 | 0.38964 |
| CAL-85-1 | Volasertib | 0.0001 | PLK | Cell cycle | 1.2817 | -0.00149 |
| CAL-85-1 | Volasertib | 0.00031623 | PLK | Cell cycle | 1.0305 | -0.00372 |
| CAL-85-1 | Volasertib | 0.001 | PLK | Cell cycle | 0.8969 | 0.03119 |
| CAL-85-1 | Volasertib | 0.0031623 | PLK | Cell cycle | 0.5300 | 0.10835 |
| CAL-85-1 | Volasertib | 0.01 | PLK | Cell cycle | -0.0789 | 0.32625 |
| CAL-85-1 | Volasertib | 0.031623 | PLK | Cell cycle | -0.2312 | 0.36670 |
| CAL-85-1 | Volasertib | 0.1 | PLK | Cell cycle | -0.2329 | 0.24551 |
| CAL-85-1 | Volasertib | 0.31623 | PLK | Cell cycle | -0.1480 | 0.17251 |
| CAL-85-1 | Volasertib | 1.0 | PLK | Cell cycle | -0.2891 | 0.24132 |
| CAL-85-1 | Dinaciclib | 0.0001 | pan CDK | Cell cycle | 0.9644 | -0.00794 |
| CAL-85-1 | Dinaciclib | 0.00031623 | pan CDK | Cell cycle | 1.0660 | -0.00550 |
| CAL-85-1 | Dinaciclib | 0.001 | pan CDK | Cell cycle | 0.9265 | 0.00424 |
| CAL-85-1 | Dinaciclib | 0.0031623 | pan CDK | Cell cycle | 0.7292 | 0.03939 |
| CAL-85-1 | Dinaciclib | 0.01 | pan CDK | Cell cycle | 0.0443 | 0.20083 |
| CAL-85-1 | Dinaciclib | 0.031623 | pan CDK | Cell cycle | -0.1777 | 0.15292 |
| CAL-85-1 | Dinaciclib | 0.1 | pan CDK | Cell cycle | -0.2312 | 0.19642 |
| CAL-85-1 | Dinaciclib | 0.31623 | pan CDK | Cell cycle | -0.2074 | 0.21038 |
| CAL-85-1 | Dinaciclib | 1.0 | pan CDK | Cell cycle | -0.2406 | 0.21946 |
| CAL-85-1 | Cisplatin | 0.0010833 | Chemo | Chemotherapy | 1.1192 | -0.00238 |
| CAL-85-1 | Cisplatin | 0.0033333 | Chemo | Chemotherapy | 1.0357 | -0.00369 |
| CAL-85-1 | Cisplatin | 0.01 | Chemo | Chemotherapy | 1.0561 | 0.00720 |
| CAL-85-1 | Cisplatin | 0.031667 | Chemo | Chemotherapy | 1.0792 | 0.00585 |
| CAL-85-1 | Cisplatin | 0.1 | Chemo | Chemotherapy | 1.0038 | 0.00985 |