Breast Cancer Profiling Project, Drug Sensitivity phase I: Fixed-cell GR measures of 35 breast cell lines to 34 small molecule perturbagens from library plate I. Dataset 1 of 2: Normalized growth rate inhibition values - Dataset (ID:20343)
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| Cell | Small Molecule | Small Mol Concentration (uM) | Primary Target | Pathway | Mean Normalized Growth Rate Inhibition Value | Increased Fraction Dead |
|---|---|---|---|---|---|---|
| HCC38 | Volasertib | 0.0001 | PLK | Cell cycle | 0.9979 | 0.00341 |
| HCC38 | Volasertib | 0.00031623 | PLK | Cell cycle | 1.0791 | 0.00818 |
| HCC38 | Volasertib | 0.001 | PLK | Cell cycle | 1.1053 | -0.00658 |
| HCC38 | Volasertib | 0.0031623 | PLK | Cell cycle | 0.9788 | 0.02414 |
| HCC38 | Volasertib | 0.01 | PLK | Cell cycle | 0.3033 | 0.19981 |
| HCC38 | Volasertib | 0.031623 | PLK | Cell cycle | -0.1516 | 0.38167 |
| HCC38 | Volasertib | 0.1 | PLK | Cell cycle | -0.2110 | 0.35627 |
| HCC38 | Volasertib | 0.31623 | PLK | Cell cycle | -0.1891 | 0.37952 |
| HCC38 | Volasertib | 1.0 | PLK | Cell cycle | -0.2598 | 0.40247 |
| HCC38 | Dinaciclib | 0.0001 | pan CDK | Cell cycle | 0.9911 | -0.00389 |
| HCC38 | Dinaciclib | 0.00031623 | pan CDK | Cell cycle | 1.0566 | -0.01304 |
| HCC38 | Dinaciclib | 0.001 | pan CDK | Cell cycle | 1.0562 | -0.01170 |
| HCC38 | Dinaciclib | 0.0031623 | pan CDK | Cell cycle | 1.1350 | -0.01256 |
| HCC38 | Dinaciclib | 0.01 | pan CDK | Cell cycle | 0.7584 | 0.03947 |
| HCC38 | Dinaciclib | 0.031623 | pan CDK | Cell cycle | -0.3744 | 0.44124 |
| HCC38 | Dinaciclib | 0.1 | pan CDK | Cell cycle | -0.4392 | 0.53030 |
| HCC38 | Dinaciclib | 0.31623 | pan CDK | Cell cycle | -0.4297 | 0.51188 |
| HCC38 | Dinaciclib | 1.0 | pan CDK | Cell cycle | -0.4422 | 0.53508 |
| HCC38 | Cisplatin | 0.0010833 | Chemo | Chemotherapy | 1.0129 | -0.00925 |
| HCC38 | Cisplatin | 0.0033333 | Chemo | Chemotherapy | 1.0467 | -0.00993 |
| HCC38 | Cisplatin | 0.01 | Chemo | Chemotherapy | 1.0111 | -0.00412 |
| HCC38 | Cisplatin | 0.031667 | Chemo | Chemotherapy | 1.0176 | -0.00306 |
| HCC38 | Cisplatin | 0.1 | Chemo | Chemotherapy | 0.9943 | 0.00541 |
| HCC38 | Cisplatin | 0.31623 | Chemo | Chemotherapy | 0.8576 | 0.07205 |
| HCC38 | Cisplatin | 1.0 | Chemo | Chemotherapy | 0.4763 | 0.19058 |