Breast Cancer Profiling Project, Drug Sensitivity phase I: Fixed-cell GR measures of 35 breast cell lines to 34 small molecule perturbagens from library plate I. Dataset 1 of 2: Normalized growth rate inhibition values - Dataset (ID:20343)

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Cell Small Molecule Small Mol Concentration (uM) Primary Target Pathway Mean Normalized Growth Rate Inhibition Value Increased Fraction Dead
MDA-MB-453 Abemaciclib
0.1
CDK4/6
Cell cycle
 0.0357 0.12572
MDA-MB-134-VI Abemaciclib
0.031623
CDK4/6
Cell cycle
 0.2769 -0.01833
MDA-MB-134-VI Abemaciclib
0.001
CDK4/6
Cell cycle
 0.6299 -0.02266
MDA-MB-453 Abemaciclib
0.31623
CDK4/6
Cell cycle
 0.0812 0.08772
MDA-MB-453 Abemaciclib
10.0
CDK4/6
Cell cycle
 -0.7647 0.62806
HCC1500 Abemaciclib
1.0
CDK4/6
Cell cycle
 0.5092 -0.01324
HCC70 Abemaciclib
0.01
CDK4/6
Cell cycle
 1.2307 -0.00284
PDX1328 Abemaciclib
0.0031623
CDK4/6
Cell cycle
 0.4756 -0.02399
MDA-MB-453 Abemaciclib
0.001
CDK4/6
Cell cycle
 0.9432 0.01922
HCC38 Abemaciclib
10.0
CDK4/6
Cell cycle
 -0.3272 0.39776
MDA-MB-453 Abemaciclib
0.0031623
CDK4/6
Cell cycle
 0.6368 0.02510
MDA-MB-453 Abemaciclib
0.01
CDK4/6
Cell cycle
 0.2434 0.09571
BT-549 Abemaciclib
1.0
CDK4/6
Cell cycle
 0.8898 0.00509
CAL-51 Abemaciclib
0.031623
CDK4/6
Cell cycle
 0.5674 -0.03450
HCC1806 Abemaciclib
0.1
CDK4/6
Cell cycle
 0.7132 0.01025
MDA-MB-453 Abemaciclib
0.031623
CDK4/6
Cell cycle
 0.0547 0.11999
HCC1500 Abemaciclib
0.1
CDK4/6
Cell cycle
 0.5535 -0.01240
HCC1500 Abemaciclib
0.31623
CDK4/6
Cell cycle
 0.6470 -0.01827
HCC1500 Abemaciclib
3.1623
CDK4/6
Cell cycle
 0.4416 -0.02996
HCC1937 Abemaciclib
3.1623
CDK4/6
Cell cycle
 0.6286 0.00631
HCC1954 Abemaciclib
0.031623
CDK4/6
Cell cycle
 0.6791 -0.00242
Hs 578T Abemaciclib
10.0
CDK4/6
Cell cycle
 -0.5825 0.84364
Hs 578T Abemaciclib
3.1623
CDK4/6
Cell cycle
 -0.2382 0.50027
Hs 578T Abemaciclib
1.0
CDK4/6
Cell cycle
 0.2262 0.17140
Hs 578T Abemaciclib
0.31623
CDK4/6
Cell cycle
 0.2917 0.09522