Breast Cancer Profiling Project, Drug Sensitivity phase I: Fixed-cell GR measures of 35 breast cell lines to 34 small molecule perturbagens from library plate I. Dataset 1 of 2: Normalized growth rate inhibition values - Dataset (ID:20343)
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| Cell | Small Molecule | Small Mol Concentration (uM) | Primary Target | Pathway | Mean Normalized Growth Rate Inhibition Value | Increased Fraction Dead |
|---|---|---|---|---|---|---|
| MDA-MB-134-VI | INK-128 | 0.00031623 | mTORC1/2 | PI3K/mTOR | 0.9671 | -0.00323 |
| MDA-MB-134-VI | Neratinib | 0.00031623 | EGFR/HER2 | RTK | 1.3354 | 0.00352 |
| BT-20 | Neratinib | 0.00031623 | EGFR/HER2 | RTK | 1.0442 | -0.00223 |
| MCF7 | INK-128 | 0.00031623 | mTORC1/2 | PI3K/mTOR | 0.9456 | 0.00258 |
| BT-549 | Palbociclib | 0.00031623 | CDK4/6 | Cell cycle | 1.0163 | 0.00360 |
| MDA-MB-134-VI | Torin2 | 0.00031623 | mTOR/ATM/ATR | PI3K/mTOR | 1.0531 | 0.00467 |
| MDA-MB-157 | Palbociclib | 0.00031623 | CDK4/6 | Cell cycle | 0.9482 | 0.00160 |
| MDA-MB-231 | INK-128 | 0.00031623 | mTORC1/2 | PI3K/mTOR | 0.9572 | 0.00181 |
| MDA-MB-134-VI | Trametinib | 0.00031623 | MEK | MAPK/nRTK | 0.9508 | 0.00935 |
| HCC1806 | Taxol | 0.00031623 | Chemo | Chemotherapy | 1.0636 | -0.00191 |
| MDA-MB-134-VI | Taxol | 0.00031623 | Chemo | Chemotherapy | 0.5566 | 0.10198 |
| MDA-MB-134-VI | Luminespib | 0.00031623 | HSP90 | Misc | 1.3361 | -0.01039 |
| MDA-MB-134-VI | Volasertib | 0.00031623 | PLK | Cell cycle | 1.4141 | 0.00230 |
| BT-549 | Dinaciclib | 0.00031623 | pan CDK | Cell cycle | 1.0210 | -0.00896 |
| MDA-MB-157 | Neratinib | 0.00031623 | EGFR/HER2 | RTK | 1.0337 | 0.00251 |
| MDA-MB-134-VI | Dinaciclib | 0.00031623 | pan CDK | Cell cycle | 1.0543 | -0.01056 |
| BT-549 | Doxorubicin | 0.00031623 | Chemo | Chemotherapy | 0.9759 | 0.00537 |
| MDA-MB-134-VI | Palbociclib | 0.00031623 | CDK4/6 | Cell cycle | 1.1665 | -0.00514 |
| MDA-MB-134-VI | Doxorubicin | 0.00031623 | Chemo | Chemotherapy | 1.1909 | 0.00067 |
| Hs 578T | Torin2 | 0.00031623 | mTOR/ATM/ATR | PI3K/mTOR | 0.9607 | 0.00174 |
| MDA-MB-361 | Taxol | 0.00031623 | Chemo | Chemotherapy | 0.9551 | 0.00737 |
| BT-549 | Taxol | 0.00031623 | Chemo | Chemotherapy | 1.0248 | 0.00400 |
| MCF 10A | Doxorubicin | 0.00031623 | Chemo | Chemotherapy | 0.9818 | 0.00026 |
| MDA-MB-231 | Torin2 | 0.00031623 | mTOR/ATM/ATR | PI3K/mTOR | 0.9887 | 0.00258 |
| MDA-MB-157 | Volasertib | 0.00031623 | PLK | Cell cycle | 1.0814 | -0.00135 |