Breast Cancer Profiling Project, Drug Sensitivity phase I: Fixed-cell GR measures of 35 breast cell lines to 34 small molecule perturbagens from library plate I. Dataset 1 of 2: Normalized growth rate inhibition values - Dataset (ID:20343)
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| Cell | Small Molecule | Small Mol Concentration (uM) | Primary Target | Pathway | Mean Normalized Growth Rate Inhibition Value | Increased Fraction Dead |
|---|---|---|---|---|---|---|
| MDA-MB-231 | Neratinib | 0.00031623 | EGFR/HER2 | RTK | 0.9892 | 0.00060 |
| Hs 578T | Torin2 | 0.00031623 | mTOR/ATM/ATR | PI3K/mTOR | 0.9607 | 0.00174 |
| HCC1806 | Doxorubicin | 0.00031623 | Chemo | Chemotherapy | 0.9295 | 0.00552 |
| MCF7 | Doxorubicin | 0.00031623 | Chemo | Chemotherapy | 0.9780 | 0.00219 |
| MDA-MB-361 | Taxol | 0.00031623 | Chemo | Chemotherapy | 0.9551 | 0.00737 |
| MDA-MB-361 | Dinaciclib | 0.00031623 | pan CDK | Cell cycle | 1.0583 | -0.00370 |
| MDA-MB-361 | Doxorubicin | 0.00031623 | Chemo | Chemotherapy | 0.8380 | 0.00327 |
| MDA-MB-361 | Palbociclib | 0.00031623 | CDK4/6 | Cell cycle | 0.9651 | 0.00223 |
| MDA-MB-361 | Volasertib | 0.00031623 | PLK | Cell cycle | 1.1354 | -0.00403 |
| MDA-MB-361 | Trametinib | 0.00031623 | MEK | MAPK/nRTK | 0.9582 | 0.00538 |
| MDA-MB-231 | INK-128 | 0.00031623 | mTORC1/2 | PI3K/mTOR | 0.9572 | 0.00181 |
| MDA-MB-157 | Torin2 | 0.00031623 | mTOR/ATM/ATR | PI3K/mTOR | 1.0129 | 0.00004 |
| MDA-MB-157 | Luminespib | 0.00031623 | HSP90 | Misc | 1.0143 | 0.00005 |
| MCF 10A | Dinaciclib | 0.00031623 | pan CDK | Cell cycle | 1.0143 | 0.00059 |
| MDA-MB-157 | INK-128 | 0.00031623 | mTORC1/2 | PI3K/mTOR | 0.9745 | -0.00090 |
| MCF7 | Palbociclib | 0.00031623 | CDK4/6 | Cell cycle | 1.0497 | -0.00053 |
| MDA-MB-157 | Trametinib | 0.00031623 | MEK | MAPK/nRTK | 0.9547 | 0.00231 |
| HCC1806 | Torin2 | 0.00031623 | mTOR/ATM/ATR | PI3K/mTOR | 0.9399 | 0.00840 |
| MDA-MB-157 | Taxol | 0.00031623 | Chemo | Chemotherapy | 1.0667 | 0.01003 |
| MDA-MB-157 | Neratinib | 0.00031623 | EGFR/HER2 | RTK | 1.0337 | 0.00251 |
| MDA-MB-157 | Volasertib | 0.00031623 | PLK | Cell cycle | 1.0814 | -0.00135 |
| MDA-MB-134-VI | Neratinib | 0.00031623 | EGFR/HER2 | RTK | 1.3354 | 0.00352 |
| MDA-MB-134-VI | INK-128 | 0.00031623 | mTORC1/2 | PI3K/mTOR | 0.9671 | -0.00323 |
| MDA-MB-157 | Palbociclib | 0.00031623 | CDK4/6 | Cell cycle | 0.9482 | 0.00160 |
| MDA-MB-157 | Dinaciclib | 0.00031623 | pan CDK | Cell cycle | 1.0629 | -0.00194 |