Breast Cancer Profiling Project, Drug Sensitivity phase I: Fixed-cell GR measures of 35 breast cell lines to 34 small molecule perturbagens from library plate I. Dataset 1 of 2: Normalized growth rate inhibition values - Dataset (ID:20343)

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Cell Small Molecule Small Mol Concentration (uM) Primary Target Pathway Mean Normalized Growth Rate Inhibition Value Increased Fraction Dead
MDA-MB-231 Dinaciclib
0.0031623
pan CDK
Cell cycle
 0.9347 -0.00315
MDA-MB-231 Dinaciclib
0.01
pan CDK
Cell cycle
 0.5305 0.05582
MDA-MB-231 Dinaciclib
1.0
pan CDK
Cell cycle
 -0.4203 0.61381
MCF7 Abemaciclib
1.0
CDK4/6
Cell cycle
 0.1092 0.05999
MCF 10A Palbociclib
1.0
CDK4/6
Cell cycle
 0.5753 -0.00773
PDX1328 AZD7762
0.0031623
CHK1/2
Cell cycle
 1.4111 0.00161
MCF7 Abemaciclib
0.0031623
CDK4/6
Cell cycle
 0.7894 0.00211
MCF7 Abemaciclib
0.001
CDK4/6
Cell cycle
 0.8973 0.00124
MCF7 Abemaciclib
0.01
CDK4/6
Cell cycle
 0.5295 0.01381
MCF7 Abemaciclib
0.031623
CDK4/6
Cell cycle
 0.3537 0.02589
HCC1806 Volasertib
0.01
PLK
Cell cycle
 -0.1860 0.51709
MCF 10A Abemaciclib
0.01
CDK4/6
Cell cycle
 0.8774 -0.00666
MCF 10A Abemaciclib
0.0031623
CDK4/6
Cell cycle
 0.9496 -0.00332
MCF 10A Abemaciclib
0.001
CDK4/6
Cell cycle
 0.9861 -0.00068
HCC1806 Abemaciclib
3.1623
CDK4/6
Cell cycle
 0.1267 0.14911
MCF 10A Abemaciclib
0.031623
CDK4/6
Cell cycle
 0.7684 -0.00888
MCF 10A Abemaciclib
0.31623
CDK4/6
Cell cycle
 0.5264 -0.00795
MCF 10A Abemaciclib
0.1
CDK4/6
Cell cycle
 0.6529 -0.00823
HCC1806 Palbociclib
0.31623
CDK4/6
Cell cycle
 0.7287 0.01539
MCF 10A Abemaciclib
10.0
CDK4/6
Cell cycle
 0.1513 0.02969
MCF 10A Palbociclib
0.0031623
CDK4/6
Cell cycle
 0.9789 -0.00222
MCF 10A Palbociclib
0.001
CDK4/6
Cell cycle
 1.0040 0.00068
MCF 10A Palbociclib
0.1
CDK4/6
Cell cycle
 0.7516 -0.00845
PDX1328 Volasertib
0.001
PLK
Cell cycle
 0.9807 0.01854
PDX1328 Volasertib
0.00031623
PLK
Cell cycle
 0.9595 0.01661