Breast Cancer Profiling Project, Drug Sensitivity phase I: Fixed-cell GR measures of 35 breast cell lines to 34 small molecule perturbagens from library plate I. Dataset 1 of 2: Normalized growth rate inhibition values - Dataset (ID:20343)

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Cell Small Molecule Small Mol Concentration (uM) Primary Target Pathway Mean Normalized Growth Rate Inhibition Value Increased Fraction Dead
BT-20 Taxol
0.031623
Chemo
Chemotherapy
 -0.5117 0.70834
PDXHCI002 Taxol
1.0
Chemo
Chemotherapy
 -0.5117 0.68548
CAMA-1 Doxorubicin
1.0
Chemo
Chemotherapy
 -0.5111 0.62817
SK-BR-3 Doxorubicin
0.31623
Chemo
Chemotherapy
 -0.5092 0.55596
HCC1806 Topotecan
3.1623
Topo I
Chemotherapy
 -0.5081 0.50830
HCC70 Dasatinib
0.31623
BCR/ABL
MAPK/nRTK
 -0.5081 0.16694
HCC70 Taxol
1.0
Chemo
Chemotherapy
 -0.5065 0.59479
SK-BR-3 INK-128
3.1623
mTORC1/2
PI3K/mTOR
 -0.5064 0.55021
HCC1395 Buparlisib
10.0
pan PI3K
PI3K/mTOR
 -0.5056 0.39115
MDA-MB-468 Ceritinib
3.1623
ALK
RTK
 -0.5054 0.58716
HCC1954 Abemaciclib
10.0
CDK4/6
Cell cycle
 -0.5049 0.68048
HCC38 Topotecan
10.0
Topo I
Chemotherapy
 -0.5041 0.48055
MDA-MB-361 Topotecan
3.1623
Topo I
Chemotherapy
 -0.5032 0.22853
HCC1419 Neratinib
3.1623
EGFR/HER2
RTK
 -0.5015 0.49177
MDA-MB-134-VI Vorinostat
10.0
HDAC
Misc
 -0.5014 0.23882
HCC70 AZD7762
0.31623
CHK1/2
Cell cycle
 -0.5001 0.53432
MDA-MB-453 Luminespib
0.31623
HSP90
Misc
 -0.4995 0.46993
MDA-MB-157 Doxorubicin
1.0
Chemo
Chemotherapy
 -0.4986 0.40596
MDA-MB-453 Vorinostat
3.1623
HDAC
Misc
 -0.4986 0.53830
MDA-MB-453 Luminespib
1.0
HSP90
Misc
 -0.4980 0.46955
MDA-MB-361 Pictilisib
3.1623
pan PI3K
PI3K/mTOR
 -0.4979 0.33498
MDA-MB-361 Volasertib
1.0
PLK
Cell cycle
 -0.4972 0.33824
PDX1258 Dinaciclib
0.031623
pan CDK
Cell cycle
 -0.4972 0.53764
HCC1500 Torin2
1.0
mTOR/ATM/ATR
PI3K/mTOR
 -0.4967 0.39873
HCC1395 Dinaciclib
1.0
pan CDK
Cell cycle
 -0.4966 0.37629