Breast Cancer Profiling Project, Drug Sensitivity phase I: Fixed-cell GR measures of 35 breast cell lines to 34 small molecule perturbagens from library plate I. Dataset 1 of 2: Normalized growth rate inhibition values - Dataset (ID:20343)

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Cell Small Molecule Small Mol Concentration (uM) Primary Target Pathway Mean Normalized Growth Rate Inhibition Value Increased Fraction Dead
BT-549 AZD7762
0.31623
CHK1/2
Cell cycle
 -0.0478 0.29963
BT-549 Volasertib
0.01
PLK
Cell cycle
 0.4084 0.12761
BT-549 Palbociclib
0.031623
CDK4/6
Cell cycle
 1.0582 -0.00203
BT-549 Palbociclib
0.01
CDK4/6
Cell cycle
 1.0649 0.00372
BT-549 Palbociclib
0.1
CDK4/6
Cell cycle
 1.0491 0.00209
BT-549 Palbociclib
0.001
CDK4/6
Cell cycle
 1.0331 0.00886
BT-549 Olaparib
3.1623
PARP
Misc
 0.8983 0.01703
BT-549 Palbociclib
0.00031623
CDK4/6
Cell cycle
 1.0163 0.00360
BT-549 Palbociclib
0.0031623
CDK4/6
Cell cycle
 1.0202 -0.00027
BT-549 Palbociclib
0.31623
CDK4/6
Cell cycle
 1.0356 -0.00357
BT-549 Abemaciclib
1.0
CDK4/6
Cell cycle
 0.8898 0.00509
BT-549 Abemaciclib
0.31623
CDK4/6
Cell cycle
 0.9772 -0.01089
BT-549 Abemaciclib
3.1623
CDK4/6
Cell cycle
 0.5941 0.02941
BT-549 Abemaciclib
0.01
CDK4/6
Cell cycle
 1.0191 0.00387
BT-549 Abemaciclib
0.031623
CDK4/6
Cell cycle
 0.9941 -0.00435
BT-549 Abemaciclib
0.1
CDK4/6
Cell cycle
 0.9609 0.00055
BT-549 Abemaciclib
10.0
CDK4/6
Cell cycle
 0.0333 0.15095
BT-549 Palbociclib
1.0
CDK4/6
Cell cycle
 1.0826 -0.00648
BT-549 Volasertib
0.031623
PLK
Cell cycle
 -0.0976 0.27861
BT-549 Taxol
0.00031623
Chemo
Chemotherapy
 1.0248 0.00400
BT-549 Abemaciclib
0.0031623
CDK4/6
Cell cycle
 1.0379 -0.00284
BT-549 Taxol
0.001
Chemo
Chemotherapy
 0.9713 0.02904
BT-549 Ipatasertib
0.1
AKT
PI3K/mTOR
 0.8348 0.00416
BT-549 Taselisib
0.1
PI3Ka, g, d
PI3K/mTOR
 0.8505 0.01194
BT-549 Taselisib
0.031623
PI3Ka, g, d
PI3K/mTOR
 0.9123 0.02093