Breast Cancer Profiling Project, Drug Sensitivity phase I: Fixed-cell GR measures of 35 breast cell lines to 34 small molecule perturbagens from library plate I. Dataset 1 of 2: Normalized growth rate inhibition values - Dataset (ID:20343)

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Cell Small Molecule Small Mol Concentration (uM) Primary Target Pathway Mean Normalized Growth Rate Inhibition Value Increased Fraction Dead
BT-20 Taselisib
0.31623
PI3Ka, g, d
PI3K/mTOR
 0.0426 0.21670
BT-20 Taselisib
10.0
PI3Ka, g, d
PI3K/mTOR
 -0.3749 0.60583
BT-20 TGX221
0.001
PI3Kb
PI3K/mTOR
 1.0702 0.00236
BT-20 TGX221
0.01
PI3Kb
PI3K/mTOR
 1.0640 0.00515
BT-20 TGX221
0.031623
PI3Kb
PI3K/mTOR
 1.0404 0.00244
BT-20 TGX221
3.1623
PI3Kb
PI3K/mTOR
 1.0471 -0.01046
BT-20 TGX221
10.0
PI3Kb
PI3K/mTOR
 1.0152 -0.00843
BT-20 Torin2
0.00031623
mTOR/ATM/ATR
PI3K/mTOR
 1.0136 0.00054
BT-20 Torin2
0.001
mTOR/ATM/ATR
PI3K/mTOR
 0.9334 0.01136
BT-20 Torin2
0.031623
mTOR/ATM/ATR
PI3K/mTOR
 0.1533 0.16173
BT-20 Torin2
0.1
mTOR/ATM/ATR
PI3K/mTOR
 0.0795 0.17945
BT-20 Torin2
1.0
mTOR/ATM/ATR
PI3K/mTOR
 -0.2891 0.53722
BT-20 Everolimus
0.001
mTOR1
PI3K/mTOR
 0.4153 0.11605
BT-20 Everolimus
0.31623
mTOR1
PI3K/mTOR
 0.4138 0.07177
BT-20 Everolimus
1.0
mTOR1
PI3K/mTOR
 0.4369 0.07155
BT-20 Everolimus
10.0
mTOR1
PI3K/mTOR
 0.3900 0.07549
BT-20 INK-128
0.00031623
mTORC1/2
PI3K/mTOR
 1.0214 -0.00216
BT-20 INK-128
0.01
mTORC1/2
PI3K/mTOR
 0.5772 0.05094
BT-20 INK-128
0.031623
mTORC1/2
PI3K/mTOR
 0.2381 0.12694
BT-20 INK-128
0.31623
mTORC1/2
PI3K/mTOR
 0.0917 0.19161
BT-20 INK-128
1.0
mTORC1/2
PI3K/mTOR
 0.0580 0.20414
BT-20 PF-4708671
0.01
p70S6K
PI3K/mTOR
 1.1177 0.00043
BT-20 PF-4708671
0.031623
p70S6K
PI3K/mTOR
 1.0436 0.00010
BT-20 Buparlisib
1.0
pan PI3K
PI3K/mTOR
 0.2586 0.12379
BT-20 Buparlisib
0.31623
pan PI3K
PI3K/mTOR
 0.7839 0.02546