Breast Cancer Profiling Project, Drug Sensitivity phase I: Fixed-cell GR measures of 35 breast cell lines to 34 small molecule perturbagens from library plate I. Dataset 1 of 2: Normalized growth rate inhibition values - Dataset (ID:20343)

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Cell Small Molecule Small Mol Concentration (uM) Primary Target Pathway Mean Normalized Growth Rate Inhibition Value Increased Fraction Dead
SUM1315MO2 AZD7762
0.001
CHK1/2
Cell cycle
 1.1615 -0.00361
HCC1500 Trametinib
0.0001
MEK
MAPK/nRTK
 1.1607 0.00453
MDA-MB-453 Luminespib
0.001
HSP90
Misc
 1.1605 0.02573
HCC1419 ABT-737
0.0031623
Bcl2/XL
Misc
 1.1602 0.00275
PDX1328 Dinaciclib
0.0031623
pan CDK
Cell cycle
 1.1598 0.00166
MDA-MB-134-VI Neratinib
0.0031623
EGFR/HER2
RTK
 1.1587 0.00073
MDA-MB-453 Buparlisib
0.001
pan PI3K
PI3K/mTOR
 1.1586 0.02359
MDA-MB-361 TGX221
0.1
PI3Kb
PI3K/mTOR
 1.1584 0.00230
HCC1500 TGX221
0.0031623
PI3Kb
PI3K/mTOR
 1.1584 0.00236
PDX1328 Cabozantinib
0.031623
VEGFR2/MET
RTK
 1.1583 -0.00150
CAMA-1 Cisplatin
0.0010833
Chemo
Chemotherapy
 1.1581 -0.00442
MDA-MB-361 Volasertib
0.001
PLK
Cell cycle
 1.1573 0.00001
HCC70 Abemaciclib
0.031623
CDK4/6
Cell cycle
 1.1572 -0.01029
MDA-MB-361 TGX221
0.031623
PI3Kb
PI3K/mTOR
 1.1566 -0.00358
HCC70 Luminespib
0.001
HSP90
Misc
 1.1566 0.00882
SK-BR-3 Saracatinib
0.31623
SRC
MAPK/nRTK
 1.1562 -0.00826
PDX1258 AZD7762
0.001
CHK1/2
Cell cycle
 1.1558 0.00421
HCC70 Luminespib
0.0001
HSP90
Misc
 1.1557 0.00993
MDA-MB-453 Saracatinib
0.0031623
SRC
MAPK/nRTK
 1.1549 0.00509
MDA-MB-134-VI PF-4708671
0.031623
p70S6K
PI3K/mTOR
 1.1546 -0.00330
MDA-MB-453 PF-4708671
0.1
p70S6K
PI3K/mTOR
 1.1545 0.00404
MDA-MB-134-VI Olaparib
0.1
PARP
Misc
 1.1545 -0.00224
SK-BR-3 Cabozantinib
0.1
VEGFR2/MET
RTK
 1.1537 -0.00868
HCC1419 Ipatasertib
0.01
AKT
PI3K/mTOR
 1.1535 -0.00296
T47D Vorinostat
0.31623
HDAC
Misc
 1.1532 0.00107