Breast Cancer Profiling Project, Drug Sensitivity phase I: Fixed-cell GR measures of 35 breast cell lines to 34 small molecule perturbagens from library plate I. Dataset 1 of 2: Normalized growth rate inhibition values - Dataset (ID:20343)

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Cell Small Molecule Small Mol Concentration (uM) Primary Target Pathway Mean Normalized Growth Rate Inhibition Value Increased Fraction Dead
MCF7 Olaparib
0.1
PARP
Misc
 1.0057 0.00013
MCF7 Olaparib
0.31623
PARP
Misc
 0.9968 0.00180
MCF7 Olaparib
1.0
PARP
Misc
 0.9705 0.00042
MCF7 Olaparib
3.1623
PARP
Misc
 0.8680 0.00852
MCF7 Olaparib
10.0
PARP
Misc
 0.5137 0.04794
MCF7 Bleomycin
0.0010833
Radiation
Misc
 0.9822 0.00000
MCF7 Bleomycin
0.0033333
Radiation
Misc
 0.9716 -0.00229
MCF7 Bleomycin
0.01
Radiation
Misc
 0.9084 -0.00275
MCF7 Bleomycin
0.031667
Radiation
Misc
 0.7580 0.00488
MCF7 Bleomycin
0.1
Radiation
Misc
 0.4305 0.06425
MCF7 Bleomycin
0.31623
Radiation
Misc
 0.1078 0.12660
MCF7 Bleomycin
1.0
Radiation
Misc
 -0.0184 0.05793
MCF7 Bleomycin
3.1623
Radiation
Misc
 -0.0459 0.03958
MCF7 Bleomycin
10.0
Radiation
Misc
 -0.0230 0.11044
MCF7 Ipatasertib
0.001
AKT
PI3K/mTOR
 0.9728 0.00441
MCF7 Ipatasertib
0.0031623
AKT
PI3K/mTOR
 0.9829 0.00469
MCF7 Ipatasertib
0.01
AKT
PI3K/mTOR
 0.9577 0.00290
MCF7 Ipatasertib
0.031623
AKT
PI3K/mTOR
 0.9327 0.00677
MCF7 Ipatasertib
0.1
AKT
PI3K/mTOR
 0.8212 0.01438
MCF7 Ipatasertib
0.31623
AKT
PI3K/mTOR
 0.6830 0.02591
MCF7 Ipatasertib
1.0
AKT
PI3K/mTOR
 0.5403 0.03530
MCF7 Ipatasertib
3.1623
AKT
PI3K/mTOR
 0.3934 0.07320
MCF7 Ipatasertib
10.0
AKT
PI3K/mTOR
 0.2497 0.14778
MCF7 Alpelisib
0.001
PI3Ka
PI3K/mTOR
 1.0440 -0.00264
MCF7 Alpelisib
0.0031623
PI3Ka
PI3K/mTOR
 1.0032 0.00120