Breast Cancer Profiling Project, Drug Sensitivity phase I: Fixed-cell GR measures of 35 breast cell lines to 34 small molecule perturbagens from library plate I. Dataset 1 of 2: Normalized growth rate inhibition values - Dataset (ID:20343)

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Cell Small Molecule Small Mol Concentration (uM) Primary Target Pathway Mean Normalized Growth Rate Inhibition Value Increased Fraction Dead
SUM1315MO2 Trametinib
0.0031623
MEK
MAPK/nRTK
 0.8484 0.02192
SUM1315MO2 Trametinib
0.01
MEK
MAPK/nRTK
 0.6506 0.02669
SUM1315MO2 Trametinib
0.031623
MEK
MAPK/nRTK
 0.4479 0.05086
SUM1315MO2 Trametinib
0.1
MEK
MAPK/nRTK
 0.2030 0.11019
SUM1315MO2 Trametinib
0.31623
MEK
MAPK/nRTK
 0.1599 0.11830
SUM1315MO2 Trametinib
1.0
MEK
MAPK/nRTK
 0.1329 0.13089
SUM1315MO2 Saracatinib
0.001
SRC
MAPK/nRTK
 1.0138 0.00035
SUM1315MO2 Saracatinib
0.0031623
SRC
MAPK/nRTK
 1.0284 0.00006
SUM1315MO2 Saracatinib
0.01
SRC
MAPK/nRTK
 0.9814 -0.00505
SUM1315MO2 Saracatinib
0.031623
SRC
MAPK/nRTK
 0.9773 0.00530
SUM1315MO2 Saracatinib
0.1
SRC
MAPK/nRTK
 0.8670 0.01128
SUM1315MO2 Saracatinib
0.31623
SRC
MAPK/nRTK
 0.7376 0.01475
SUM1315MO2 Saracatinib
1.0
SRC
MAPK/nRTK
 0.5761 0.04940
SUM1315MO2 Saracatinib
3.1623
SRC
MAPK/nRTK
 0.3317 0.10537
SUM1315MO2 Saracatinib
10.0
SRC
MAPK/nRTK
 0.0846 0.18472
SUM1315MO2 ABT-737
0.001
Bcl2/XL
Misc
 1.0978 0.00082
SUM1315MO2 ABT-737
0.0031623
Bcl2/XL
Misc
 1.1225 -0.00610
SUM1315MO2 ABT-737
0.01
Bcl2/XL
Misc
 1.0525 0.00817
SUM1315MO2 ABT-737
0.031623
Bcl2/XL
Misc
 1.0828 0.00422
SUM1315MO2 ABT-737
0.1
Bcl2/XL
Misc
 0.9196 0.02613
SUM1315MO2 ABT-737
0.31623
Bcl2/XL
Misc
 0.9598 0.02513
SUM1315MO2 ABT-737
1.0
Bcl2/XL
Misc
 0.7599 0.04604
SUM1315MO2 ABT-737
3.1623
Bcl2/XL
Misc
 0.7434 0.07861
SUM1315MO2 ABT-737
10.0
Bcl2/XL
Misc
 0.3056 0.14075
SUM1315MO2 Vorinostat
0.001
HDAC
Misc
 1.0981 0.00046