Breast Cancer Profiling Project, Drug Sensitivity phase I: Fixed-cell GR measures of 35 breast cell lines to 34 small molecule perturbagens from library plate I. Dataset 1 of 2: Normalized growth rate inhibition values - Dataset (ID:20343)
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| Cell | Small Molecule | Small Mol Concentration (uM) | Primary Target | Pathway | Mean Normalized Growth Rate Inhibition Value | Increased Fraction Dead |
|---|---|---|---|---|---|---|
| HCC1428 | Bleomycin | 0.01 | Radiation | Misc | 0.8377 | -0.00689 |
| HCC1428 | Bleomycin | 0.031667 | Radiation | Misc | 0.9285 | -0.00213 |
| HCC1428 | Bleomycin | 0.1 | Radiation | Misc | 1.0030 | -0.00050 |
| HCC1428 | Bleomycin | 0.31623 | Radiation | Misc | 0.8498 | 0.01401 |
| HCC1428 | Bleomycin | 1.0 | Radiation | Misc | 0.8502 | 0.02733 |
| HCC1428 | Bleomycin | 3.1623 | Radiation | Misc | 0.5818 | 0.04615 |
| HCC1428 | Bleomycin | 10.0 | Radiation | Misc | 0.2173 | 0.07466 |
| HCC1428 | Ipatasertib | 0.001 | AKT | PI3K/mTOR | 1.0193 | -0.00205 |
| HCC1428 | Ipatasertib | 0.0031623 | AKT | PI3K/mTOR | 1.0504 | 0.00165 |
| HCC1428 | Ipatasertib | 0.01 | AKT | PI3K/mTOR | 1.1101 | 0.00165 |
| HCC1428 | Ipatasertib | 0.031623 | AKT | PI3K/mTOR | 1.1717 | -0.00194 |
| HCC1428 | Ipatasertib | 0.1 | AKT | PI3K/mTOR | 1.0873 | -0.00406 |
| HCC1428 | Ipatasertib | 0.31623 | AKT | PI3K/mTOR | 1.0329 | 0.00070 |
| HCC1428 | Ipatasertib | 1.0 | AKT | PI3K/mTOR | 1.0181 | -0.00100 |
| HCC1428 | Ipatasertib | 3.1623 | AKT | PI3K/mTOR | 1.1206 | -0.00248 |
| HCC1428 | Ipatasertib | 10.0 | AKT | PI3K/mTOR | 0.9911 | 0.00685 |
| HCC1428 | Alpelisib | 0.001 | PI3Ka | PI3K/mTOR | 0.9223 | -0.00254 |
| HCC1428 | Alpelisib | 0.0031623 | PI3Ka | PI3K/mTOR | 1.0039 | -0.00083 |
| HCC1428 | Alpelisib | 0.01 | PI3Ka | PI3K/mTOR | 1.0737 | 0.00072 |
| HCC1428 | Alpelisib | 0.031623 | PI3Ka | PI3K/mTOR | 1.0623 | 0.00119 |
| HCC1428 | Alpelisib | 0.1 | PI3Ka | PI3K/mTOR | 1.0902 | 0.00150 |
| HCC1428 | Alpelisib | 0.31623 | PI3Ka | PI3K/mTOR | 0.8718 | 0.00264 |
| HCC1428 | Alpelisib | 1.0 | PI3Ka | PI3K/mTOR | 1.0037 | 0.00438 |
| HCC1428 | Alpelisib | 3.1623 | PI3Ka | PI3K/mTOR | 0.9210 | 0.00155 |
| HCC1428 | Alpelisib | 10.0 | PI3Ka | PI3K/mTOR | 0.8530 | 0.01889 |