Breast Cancer Profiling Project, Drug Sensitivity phase I: Fixed-cell GR measures of 35 breast cell lines to 34 small molecule perturbagens from library plate I. Dataset 1 of 2: Normalized growth rate inhibition values - Dataset (ID:20343)

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Cell Small Molecule Small Mol Concentration (uM) Primary Target Pathway Mean Normalized Growth Rate Inhibition Value Increased Fraction Dead
SUM149PT Trametinib
1.0
MEK
MAPK/nRTK
 0.2403 0.11012
SUM149PT Saracatinib
0.001
SRC
MAPK/nRTK
 1.0230 0.00136
SUM149PT Saracatinib
0.0031623
SRC
MAPK/nRTK
 0.9720 0.00283
SUM149PT Saracatinib
0.01
SRC
MAPK/nRTK
 1.0532 0.00380
SUM149PT Saracatinib
0.031623
SRC
MAPK/nRTK
 1.0496 -0.00032
SUM149PT Saracatinib
0.1
SRC
MAPK/nRTK
 1.0464 0.00309
SUM149PT Saracatinib
0.31623
SRC
MAPK/nRTK
 0.9918 0.00201
SUM149PT Saracatinib
1.0
SRC
MAPK/nRTK
 0.7600 0.02374
SUM149PT Saracatinib
3.1623
SRC
MAPK/nRTK
 0.4246 0.10732
SUM149PT Saracatinib
10.0
SRC
MAPK/nRTK
 0.1835 0.16888
SUM149PT ABT-737
0.001
Bcl2/XL
Misc
 1.0183 0.00068
SUM149PT ABT-737
0.0031623
Bcl2/XL
Misc
 1.0203 0.00117
SUM149PT ABT-737
0.01
Bcl2/XL
Misc
 1.0139 0.00586
SUM149PT ABT-737
0.031623
Bcl2/XL
Misc
 1.0000 0.00782
SUM149PT ABT-737
0.1
Bcl2/XL
Misc
 0.9736 0.01945
SUM149PT ABT-737
0.31623
Bcl2/XL
Misc
 0.9717 0.02604
SUM149PT ABT-737
1.0
Bcl2/XL
Misc
 0.8735 0.06533
SUM149PT ABT-737
3.1623
Bcl2/XL
Misc
 0.5780 0.19223
SUM149PT ABT-737
10.0
Bcl2/XL
Misc
 -0.2913 0.68878
SUM149PT Vorinostat
0.001
HDAC
Misc
 1.0183 0.00032
SUM149PT Vorinostat
0.0031623
HDAC
Misc
 1.0188 -0.00142
SUM149PT Vorinostat
0.01
HDAC
Misc
 0.9955 0.00190
SUM149PT Vorinostat
0.031623
HDAC
Misc
 0.9957 0.00985
SUM149PT Vorinostat
0.1
HDAC
Misc
 0.9971 0.00797
SUM149PT Vorinostat
0.31623
HDAC
Misc
 0.9176 0.01320