Breast Cancer Profiling Project, Drug Sensitivity phase I: Fixed-cell GR measures of 35 breast cell lines to 34 small molecule perturbagens from library plate I. Dataset 1 of 2: Normalized growth rate inhibition values - Dataset (ID:20343)
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| Cell | Small Molecule | Small Mol Concentration (uM) | Primary Target | Pathway | Mean Normalized Growth Rate Inhibition Value | Increased Fraction Dead |
|---|---|---|---|---|---|---|
| PDXHCI002 | Bleomycin | 0.0033333 | Radiation | Misc | 1.0207 | 0.00046 |
| PDXHCI002 | Bleomycin | 0.01 | Radiation | Misc | 1.0386 | -0.02725 |
| PDXHCI002 | Bleomycin | 0.031667 | Radiation | Misc | 0.9519 | -0.03029 |
| PDXHCI002 | Bleomycin | 0.1 | Radiation | Misc | 0.9239 | -0.04511 |
| PDXHCI002 | Bleomycin | 0.31623 | Radiation | Misc | 0.7964 | -0.08259 |
| PDXHCI002 | Bleomycin | 1.0 | Radiation | Misc | 0.5681 | -0.08965 |
| PDXHCI002 | Bleomycin | 3.1623 | Radiation | Misc | 0.1591 | -0.06333 |
| PDXHCI002 | Bleomycin | 10.0 | Radiation | Misc | -0.1199 | -0.00457 |
| PDXHCI002 | Ipatasertib | 0.001 | AKT | PI3K/mTOR | 1.0303 | -0.00319 |
| PDXHCI002 | Ipatasertib | 0.0031623 | AKT | PI3K/mTOR | 1.0733 | 0.00260 |
| PDXHCI002 | Ipatasertib | 0.01 | AKT | PI3K/mTOR | 1.0750 | -0.00277 |
| PDXHCI002 | Ipatasertib | 0.031623 | AKT | PI3K/mTOR | 1.1203 | 0.00168 |
| PDXHCI002 | Ipatasertib | 0.1 | AKT | PI3K/mTOR | 1.0651 | -0.01212 |
| PDXHCI002 | Ipatasertib | 0.31623 | AKT | PI3K/mTOR | 1.1369 | -0.00729 |
| PDXHCI002 | Ipatasertib | 1.0 | AKT | PI3K/mTOR | 1.1747 | -0.02620 |
| PDXHCI002 | Ipatasertib | 3.1623 | AKT | PI3K/mTOR | 1.1981 | -0.01884 |
| PDXHCI002 | Ipatasertib | 10.0 | AKT | PI3K/mTOR | 1.0989 | -0.03489 |
| PDXHCI002 | Alpelisib | 0.001 | PI3Ka | PI3K/mTOR | 0.9855 | -0.00673 |
| PDXHCI002 | Alpelisib | 0.0031623 | PI3Ka | PI3K/mTOR | 1.0478 | 0.00252 |
| PDXHCI002 | Alpelisib | 0.01 | PI3Ka | PI3K/mTOR | 1.0503 | -0.00396 |
| PDXHCI002 | Alpelisib | 0.031623 | PI3Ka | PI3K/mTOR | 1.0273 | -0.00445 |
| PDXHCI002 | Alpelisib | 0.1 | PI3Ka | PI3K/mTOR | 0.9768 | -0.00800 |
| PDXHCI002 | Alpelisib | 0.31623 | PI3Ka | PI3K/mTOR | 0.9314 | -0.00707 |
| PDXHCI002 | Alpelisib | 1.0 | PI3Ka | PI3K/mTOR | 0.8337 | -0.00572 |
| PDXHCI002 | Alpelisib | 3.1623 | PI3Ka | PI3K/mTOR | 0.8213 | -0.00771 |