Breast Cancer Profiling Project, Drug Sensitivity phase I: Fixed-cell GR measures of 35 breast cell lines to 34 small molecule perturbagens from library plate I. Dataset 1 of 2: Normalized growth rate inhibition values - Dataset (ID:20343)

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Cell Small Molecule Small Mol Concentration (uM) Primary Target Pathway Mean Normalized Growth Rate Inhibition Value Increased Fraction Dead
CAL-120 TGX221
10.0
PI3Kb
PI3K/mTOR
 1.0198 -0.00680
CAL-120 Torin2
0.0001
mTOR/ATM/ATR
PI3K/mTOR
 1.0367 -0.00466
CAL-120 Torin2
0.00031623
mTOR/ATM/ATR
PI3K/mTOR
 0.9759 -0.00583
CAL-120 Torin2
0.001
mTOR/ATM/ATR
PI3K/mTOR
 0.9557 -0.00769
CAL-120 Torin2
0.0031623
mTOR/ATM/ATR
PI3K/mTOR
 0.8087 -0.01071
CAL-120 Torin2
0.01
mTOR/ATM/ATR
PI3K/mTOR
 0.5326 -0.00189
CAL-120 Torin2
0.031623
mTOR/ATM/ATR
PI3K/mTOR
 0.1813 0.04887
CAL-120 Torin2
0.1
mTOR/ATM/ATR
PI3K/mTOR
 0.0879 0.08174
CAL-120 Torin2
0.31623
mTOR/ATM/ATR
PI3K/mTOR
 0.0477 0.12084
CAL-120 Torin2
1.0
mTOR/ATM/ATR
PI3K/mTOR
 -0.0115 0.21564
CAL-120 Everolimus
0.001
mTOR1
PI3K/mTOR
 0.6669 -0.00811
CAL-120 Everolimus
0.0031623
mTOR1
PI3K/mTOR
 0.6255 -0.00487
CAL-120 Everolimus
0.01
mTOR1
PI3K/mTOR
 0.5765 -0.00322
CAL-120 Everolimus
0.031623
mTOR1
PI3K/mTOR
 0.6171 -0.01279
CAL-120 Everolimus
0.1
mTOR1
PI3K/mTOR
 0.5661 -0.00398
CAL-120 Everolimus
0.31623
mTOR1
PI3K/mTOR
 0.5924 -0.00455
CAL-120 Everolimus
1.0
mTOR1
PI3K/mTOR
 0.5518 -0.00832
CAL-120 Everolimus
3.1623
mTOR1
PI3K/mTOR
 0.5431 -0.00214
CAL-120 Everolimus
10.0
mTOR1
PI3K/mTOR
 0.5275 0.00272
CAL-120 INK-128
0.00031623
mTORC1/2
PI3K/mTOR
 0.9938 -0.00257
CAL-120 INK-128
0.001
mTORC1/2
PI3K/mTOR
 0.9319 -0.00808
CAL-120 INK-128
0.0031623
mTORC1/2
PI3K/mTOR
 0.8476 -0.01120
CAL-120 INK-128
0.01
mTORC1/2
PI3K/mTOR
 0.5607 -0.00278
CAL-120 INK-128
0.031623
mTORC1/2
PI3K/mTOR
 0.1969 0.04538
CAL-120 INK-128
0.1
mTORC1/2
PI3K/mTOR
 0.0607 0.09033