LINCS MCF 10A Common Project: Rolling-time-point sensitivity measures of the MCF 10A breast cell line to 8 small molecule perturbagens. Dataset 15 of 15: Time-dependent dose-response metrics for biological replicate 3. - Dataset (ID:20323)
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| Cell | Small Molecule | Time Point (hr) | Time Interval (hr) | GR50 | GEC50 | GRmax | GRinf | GR Hill Coefficient | GR_AOC |
|---|---|---|---|---|---|---|---|---|---|
| MCF 10A-H2B-mCherry | Etoposide | 49.15 | 11.9 | 0.181 | 0.1972 | -0.0356 | -0.0390 | 1.4702 | 0.4503 |
| MCF 10A-H2B-mCherry | Etoposide | 50.86 | 11.9 | 0.1673 | 0.1941 | -0.0376 | -0.0886 | 1.3933 | 0.4842 |
| MCF 10A-H2B-mCherry | Etoposide | 52.56 | 11.9 | 0.1834 | 0.2112 | -0.0412 | -0.0871 | 1.3654 | 0.4720 |
| MCF 10A-H2B-mCherry | Etoposide | 54.25 | 11.9 | 0.1962 | 0.2422 | -0.0801 | -0.1386 | 1.2968 | 0.4813 |
| MCF 10A-H2B-mCherry | Etoposide | 55.97 | 11.9 | 0.1764 | 0.2158 | -0.1032 | -0.1437 | 1.3070 | 0.4899 |
| MCF 10A-H2B-mCherry | Etoposide | 57.67 | 11.9 | 0.1904 | 0.2387 | -0.0862 | -0.1669 | 1.3990 | 0.4917 |
| MCF 10A-H2B-mCherry | Etoposide | 59.37 | 11.9 | 0.175 | 0.2286 | -0.1643 | -0.2147 | 1.3502 | 0.5215 |
| MCF 10A-H2B-mCherry | Etoposide | 61.08 | 11.9 | 0.1803 | 0.2407 | -0.2374 | -0.2528 | 1.4847 | 0.5320 |
| MCF 10A-H2B-mCherry | Etoposide | 62.78 | 11.9 | 0.1994 | 0.2559 | -0.2172 | -0.2324 | 1.7133 | 0.5281 |
| MCF 10A-H2B-mCherry | Etoposide | 64.49 | 11.9 | 0.2065 | 0.2637 | -0.3298 | -0.2839 | 1.8396 | 0.5592 |
| MCF 10A-H2B-mCherry | Etoposide | 66.19 | 11.9 | 0.2566 | 0.3082 | -0.2908 | -0.2869 | 3.3623 | 0.5574 |
| MCF 10A-H2B-mCherry | Etoposide | 67.89 | 11.9 | 0.2369 | 0.296 | -0.2685 | -0.3267 | 3.4357 | 0.5958 |
| MCF 10A-H2B-mCherry | Etoposide | 69.60 | 11.9 | 0.2123 | 0.2955 | -0.4801 | -0.4544 | 3.3746 | 0.6655 |
| MCF 10A-H2B-mCherry | Etoposide | 71.30 | 11.9 | Inf | Inf | -0.6076 | -0.5220 | 0.7739 | 0.7550 |
| MCF 10A-H2B-mCherry | Etoposide | 73.49 | 11.9 | Inf | Inf | -0.6007 | -0.6007 | 0.0000 | 0.9782 |
| MCF 10A-H2B-mCherry | Etoposide | 76.90 | 11.9 | Inf | Inf | -0.8928 | -0.8928 | 0.0000 | 1.0768 |
| MCF 10A-H2B-mCherry | Etoposide | 80.31 | 11.9 | Inf | Inf | -0.9514 | -0.9514 | 0.0000 | 1.1514 |
| MCF 10A-H2B-mCherry | Etoposide | 85.43 | 11.9 | Inf | Inf | -0.8878 | -0.8878 | 0.0000 | 1.1597 |
| MCF 10A-H2B-mCherry | Etoposide | 85.43 | 12.0 | Inf | Inf | -0.8811 | -0.8811 | 0.0000 | 1.1884 |
| MCF 10A-H2B-mCherry | Etoposide | 89.69 | 11.9 | Inf | Inf | -0.7330 | -0.7330 | 0.0000 | 1.3084 |
| MCF 10A-H2B-mCherry | Neratinib | 15.08 | 11.9 | 0.0426 | 0.0275 | 0.1256 | 0.3067 | 3.0534 | 0.4072 |
| MCF 10A-H2B-mCherry | Neratinib | 16.79 | 11.9 | 0.0408 | 0.0286 | 0.0286 | 0.2638 | 3.0072 | 0.4249 |
| MCF 10A-H2B-mCherry | Neratinib | 18.49 | 11.9 | 0.0349 | 0.027 | -0.0435 | 0.1298 | 0.9796 | 0.4721 |
| MCF 10A-H2B-mCherry | Neratinib | 20.19 | 11.9 | 0.0265 | 0.0223 | -0.1108 | 0.1112 | 1.3534 | 0.5062 |
| MCF 10A-H2B-mCherry | Neratinib | 21.90 | 11.9 | 0.0207 | 0.0191 | -0.1246 | 0.0444 | 1.2557 | 0.5569 |