LINCS MCF 10A Common Project: Rolling-time-point sensitivity measures of the MCF 10A breast cell line to 8 small molecule perturbagens. Dataset 13 of 15: Time-dependent dose-response metrics for biological replicate 1. - Dataset (ID:20321)
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| Cell | Small Molecule | Time Point (hr) | Time Interval (hr) | GR50 | GEC50 | GRmax | GRinf | GR Hill Coefficient | GR_AOC |
|---|---|---|---|---|---|---|---|---|---|
| MCF 10A-H2B-mCherry | Trametinib | 74.16 | 13.4 | 0.0303 | 0.0298 | -0.0034 | 0.0350 | 5.0000 | 0.3753 |
| MCF 10A-H2B-mCherry | Trametinib | 71.94 | 13.4 | 0.0301 | 0.0295 | -0.0284 | 0.0490 | 5.0000 | 0.3826 |
| MCF 10A-H2B-mCherry | Taxol | 71.94 | 13.4 | 0.0024 | 0.0025 | -0.4059 | -0.1917 | 5.0000 | 0.6660 |
| MCF 10A-H2B-mCherry | Taxol | 80.82 | 13.4 | 0.0029 | 0.0033 | -0.4208 | -0.4210 | 5.0000 | 0.7492 |
| MCF 10A-H2B-mCherry | Taxol | 76.38 | 13.4 | 0.0027 | 0.003 | -0.3872 | -0.2827 | 5.0000 | 0.7081 |
| MCF 10A-H2B-mCherry | Taxol | 67.47 | 13.3 | 0.0019 | 0.002 | -0.1129 | -0.0505 | 5.0000 | 0.6016 |
| MCF 10A-H2B-mCherry | Neratinib | 80.82 | 13.4 | 2.3453 | 2.9216 | -0.1941 | -0.9999 | 5.0000 | 0.1566 |
| MCF 10A-H2B-mCherry | Dasatinib | 80.82 | 13.4 | 2.6268 | 3.1186 | -0.6670 | -0.6812 | 5.0000 | 0.2539 |
| MCF 10A-H2B-mCherry | Dasatinib | 71.94 | 13.4 | 2.6626 | 3.0476 | -0.4700 | -0.4838 | 5.0000 | 0.1943 |
| MCF 10A-H2B-mCherry | Taxol | 78.60 | 13.4 | 0.0027 | 0.003 | -0.4567 | -0.3897 | 5.0000 | 0.7535 |
| MCF 10A-H2B-mCherry | Taxol | 63.02 | 13.3 | 0.0018 | 0.0018 | 0.0879 | -0.0920 | 5.0000 | 0.6130 |
| MCF 10A-H2B-mCherry | Dasatinib | 67.47 | 13.3 | 2.6267 | 2.9115 | -0.3174 | -0.3370 | 5.0000 | 0.2139 |
| MCF 10A-H2B-mCherry | Dasatinib | 60.80 | 13.3 | 2.6142 | 2.8457 | -0.2483 | -0.2665 | 5.0000 | 0.2204 |
| MCF 10A-H2B-mCherry | Neratinib | 56.36 | 13.3 | 0.2871 | 0.2961 | -0.1936 | -0.0838 | 5.0000 | 0.2660 |
| MCF 10A-H2B-mCherry | Neratinib | 69.71 | 13.4 | 0.5895 | 0.6414 | -0.3513 | -0.2624 | 5.0000 | 0.2420 |
| MCF 10A-H2B-mCherry | Neratinib | 51.92 | 13.3 | 0.2723 | 0.2778 | -0.1512 | -0.0524 | 5.0000 | 0.2690 |
| MCF 10A-H2B-mCherry | Dasatinib | 63.02 | 13.3 | 2.5721 | 2.791 | -0.2366 | -0.2566 | 5.0000 | 0.2329 |
| MCF 10A-H2B-mCherry | Dasatinib | 65.24 | 13.3 | 2.6262 | 2.9014 | -0.3088 | -0.3272 | 5.0000 | 0.2266 |
| MCF 10A-H2B-mCherry | Dasatinib | 78.60 | 13.4 | 2.6077 | 3.0672 | -0.6115 | -0.6256 | 5.0000 | 0.2331 |
| MCF 10A-H2B-mCherry | Dasatinib | 76.38 | 13.4 | 2.6411 | 3.1142 | -0.6260 | -0.6410 | 5.0000 | 0.2153 |
| MCF 10A-H2B-mCherry | Neratinib | 54.14 | 13.3 | 0.2668 | 0.2739 | -0.2193 | -0.0720 | 5.0000 | 0.2803 |
| MCF 10A-H2B-mCherry | Dasatinib | 74.16 | 13.4 | 2.6047 | 3.0088 | -0.5134 | -0.5296 | 5.0000 | 0.2140 |
| MCF 10A-H2B-mCherry | Dasatinib | 69.71 | 13.4 | 2.5863 | 2.9033 | -0.3708 | -0.3922 | 5.0000 | 0.2048 |
| MCF 10A-H2B-mCherry | Trametinib | 78.60 | 13.4 | 0.0337 | 0.0328 | 0.0005 | 0.0659 | 5.0000 | 0.3496 |
| MCF 10A-H2B-mCherry | Trametinib | 76.38 | 13.4 | 0.0309 | 0.0305 | -0.0623 | 0.0243 | 5.0000 | 0.3705 |