LINCS MCF 10A Common Project: Rolling-time-point sensitivity measures of the MCF 10A breast cell line to 8 small molecule perturbagens. Dataset 8 of 15: End-point dose-response metrics for biological replicate 2. - Dataset (ID:20316)
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| Cell | Small Molecule | Time Point (hr) | GR50 | GEC50 | GRmax | GRinf | GR Hill Coefficient | GR_AOC |
|---|---|---|---|---|---|---|---|---|
| MCF 10A-H2B-mCherry | Palbociclib | 24 | Inf | Inf | 0.3926 | 0.3926 | 0.0000 | 0.3827 |
| MCF 10A-H2B-mCherry | Palbociclib | 36 | Inf | Inf | 0.3397 | 0.3397 | 0.0000 | 0.3606 |
| MCF 10A-H2B-mCherry | Palbociclib | 48 | Inf | Inf | 0.3655 | 0.3655 | 0.0000 | 0.3443 |
| MCF 10A-H2B-mCherry | Palbociclib | 72 | Inf | Inf | 0.4218 | 0.4218 | 0.0000 | 0.3265 |
| MCF 10A-H2B-mCherry | Palbociclib | 84 | Inf | Inf | 0.3876 | 0.3876 | 0.0000 | 0.3349 |
| MCF 10A-H2B-mCherry | Taxol | 12 | 0.0005 | 0.0007 | 0.2488 | -0.0238 | 0.1003 | 0.5527 |
| MCF 10A-H2B-mCherry | Taxol | 24 | 0.0018 | 0.0505 | -0.2179 | -1.0000 | 0.3299 | 0.6617 |
| MCF 10A-H2B-mCherry | Taxol | 36 | 0.0012 | 0.004 | -0.2810 | -0.4927 | 0.5556 | 0.7513 |
| MCF 10A-H2B-mCherry | Taxol | 48 | 0.0009 | 0.0023 | -0.2904 | -0.4105 | 0.6256 | 0.7874 |
| MCF 10A-H2B-mCherry | Taxol | 72 | 0.0005 | 0.0011 | -0.2898 | -0.3494 | 0.6605 | 0.8468 |
| MCF 10A-H2B-mCherry | Taxol | 84 | 0.0003 | 0.0008 | -0.2773 | -0.3429 | 0.6241 | 0.8762 |
| MCF 10A-H2B-mCherry | Trametinib | 12 | Inf | Inf | 0.5691 | 0.5691 | 0.0000 | 0.4204 |
| MCF 10A-H2B-mCherry | Trametinib | 24 | Inf | Inf | 0.7135 | 0.7135 | 0.0000 | 0.3120 |
| MCF 10A-H2B-mCherry | Trametinib | 36 | Inf | Inf | 0.6568 | 0.6568 | 0.0000 | 0.3354 |
| MCF 10A-H2B-mCherry | Trametinib | 48 | Inf | 0.0003 | 0.5877 | 0.5701 | 0.3964 | 0.3405 |
| MCF 10A-H2B-mCherry | Trametinib | 72 | Inf | 0.0048 | 0.5610 | 0.5286 | 0.5137 | 0.2868 |
| MCF 10A-H2B-mCherry | Trametinib | 84 | 6.7955 | 0.0263 | 0.5589 | 0.3962 | 0.2830 | 0.2816 |
| MCF 10A-H2B-mCherry | Vorinostat | 12 | Inf | Inf | 0.4594 | 0.4594 | 0.0000 | 0.4495 |
| MCF 10A-H2B-mCherry | Vorinostat | 24 | 1.2461 | 204.8226 | 0.2649 | -1.0000 | 0.2153 | 0.3813 |
| MCF 10A-H2B-mCherry | Vorinostat | 36 | 1.0852 | 20.5497 | 0.1559 | -1.0000 | 0.3735 | 0.3694 |
| MCF 10A-H2B-mCherry | Vorinostat | 48 | 1.111 | 15.0584 | 0.1025 | -1.0000 | 0.4215 | 0.3662 |
| MCF 10A-H2B-mCherry | Vorinostat | 72 | 1.435 | 21.5194 | 0.1227 | -1.0000 | 0.4057 | 0.3663 |
| MCF 10A-H2B-mCherry | Vorinostat | 84 | 1.1734 | 54.8915 | 0.1209 | -1.0000 | 0.2857 | 0.4069 |