LINCS MCF 10A Common Project: Rolling-time-point sensitivity measures of the MCF 10A breast cell line to 8 small molecule perturbagens. Dataset 8 of 15: End-point dose-response metrics for biological replicate 2. - Dataset (ID:20316)
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| Cell | Small Molecule | Time Point (hr) | GR50 | GEC50 | GRmax | GRinf | GR Hill Coefficient | GR_AOC |
|---|---|---|---|---|---|---|---|---|
| MCF 10A-H2B-mCherry | Alpelisib | 12 | Inf | Inf | 0.5346 | 0.5346 | 0.0000 | 0.4462 |
| MCF 10A-H2B-mCherry | Alpelisib | 24 | Inf | Inf | 0.6050 | 0.6050 | 0.0000 | 0.3309 |
| MCF 10A-H2B-mCherry | Alpelisib | 36 | Inf | Inf | 0.7055 | 0.7055 | 0.0000 | 0.2829 |
| MCF 10A-H2B-mCherry | Alpelisib | 48 | Inf | Inf | 0.7368 | 0.7368 | 0.0000 | 0.2612 |
| MCF 10A-H2B-mCherry | Alpelisib | 72 | Inf | Inf | 0.8047 | 0.8047 | 0.0000 | 0.2441 |
| MCF 10A-H2B-mCherry | Alpelisib | 84 | Inf | Inf | 0.7374 | 0.7374 | 0.0000 | 0.3018 |
| MCF 10A-H2B-mCherry | Dasatinib | 12 | Inf | Inf | 0.4761 | 0.4761 | 0.0000 | 0.4903 |
| MCF 10A-H2B-mCherry | Dasatinib | 24 | Inf | Inf | 0.3885 | 0.3885 | 0.0000 | 0.4429 |
| MCF 10A-H2B-mCherry | Dasatinib | 36 | Inf | Inf | 0.3554 | 0.3554 | 0.0000 | 0.4191 |
| MCF 10A-H2B-mCherry | Dasatinib | 48 | Inf | Inf | 0.3357 | 0.3357 | 0.0000 | 0.3927 |
| MCF 10A-H2B-mCherry | Dasatinib | 72 | Inf | Inf | 0.2033 | 0.2033 | 0.0000 | 0.3884 |
| MCF 10A-H2B-mCherry | Dasatinib | 84 | Inf | Inf | 0.1459 | 0.1459 | 0.0000 | 0.4301 |
| MCF 10A-H2B-mCherry | Etoposide | 12 | Inf | Inf | 0.3263 | 0.3263 | 0.0000 | 0.4338 |
| MCF 10A-H2B-mCherry | Etoposide | 24 | Inf | Inf | 0.2285 | 0.2285 | 0.0000 | 0.3229 |
| MCF 10A-H2B-mCherry | Etoposide | 36 | 1.7174 | 246.1221 | 0.1871 | -1.0000 | 0.2213 | 0.3418 |
| MCF 10A-H2B-mCherry | Etoposide | 48 | 1.0407 | 79.7605 | 0.1715 | -1.0000 | 0.2532 | 0.3575 |
| MCF 10A-H2B-mCherry | Etoposide | 72 | 0.4072 | 92.5315 | 0.1613 | -1.0000 | 0.2025 | 0.4334 |
| MCF 10A-H2B-mCherry | Etoposide | 84 | 0.1739 | 59.2726 | 0.1678 | -1.0000 | 0.1884 | 0.4947 |
| MCF 10A-H2B-mCherry | Neratinib | 12 | Inf | Inf | 0.4696 | 0.4696 | 0.0000 | 0.4345 |
| MCF 10A-H2B-mCherry | Neratinib | 24 | 0.3492 | 0.0073 | 0.4236 | 0.3755 | 0.3591 | 0.3870 |
| MCF 10A-H2B-mCherry | Neratinib | 36 | 0.1336 | 0.0994 | 0.2934 | 0.0455 | 0.3225 | 0.4123 |
| MCF 10A-H2B-mCherry | Neratinib | 48 | 0.2009 | 11.344 | 0.1627 | -1.0000 | 0.2724 | 0.3954 |
| MCF 10A-H2B-mCherry | Neratinib | 72 | 0.2915 | 6.6939 | 0.0859 | -1.0000 | 0.3505 | 0.3727 |
| MCF 10A-H2B-mCherry | Neratinib | 84 | 0.2528 | 9.4484 | 0.0272 | -1.0000 | 0.3034 | 0.3990 |
| MCF 10A-H2B-mCherry | Palbociclib | 12 | Inf | Inf | 0.4654 | 0.4654 | 0.0000 | 0.4378 |