Viability and apoptosis measured by imaging in BRAF(V600E/D) melanoma cell lines following treatment with combinations of three compounds (viability/apoptosis dataset 2 of 2) - Dataset (ID:20273)

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Cell Small Molecule 1 Small Molecule 2 Small Molecule 3 Small Mol 1 Concentration Small Mol 2 Concentration Small Mol 3 Concentration Small Mol Conc Unit Time Point Time Point Unit Replicate Total Number of Cells (Nuclei) Number of Apoptotic Cells Relative Viability Mean Relative Viability Apoptosis Fraction Mean Apoptosis Fraction
COLO 858 Vemurafenib Trametinib Defactinib 0.1000 0.0100 0.3160
uM
 72
hr
 1 1246 986 0.0366 0.0435 0.7913 0.7870
COLO 858 Vemurafenib Trametinib Defactinib 0.1000 0.0100 0.3160
uM
 72
hr
 2 1509 1177 0.0467 0.0435 0.7800 0.7870
COLO 858 Vemurafenib Trametinib Defactinib 0.1000 0.0100 0.3160
uM
 72
hr
 3 1598 1262 0.0473 0.0435 0.7897 0.7870
COLO 858 Vemurafenib Trametinib Defactinib 0.1000 0.0100 1.0000
uM
 72
hr
 1 1328 1091 0.0334 0.0295 0.8215 0.8149
COLO 858 Vemurafenib Trametinib Defactinib 0.1000 0.0100 1.0000
uM
 72
hr
 2 1035 844 0.0269 0.0295 0.8155 0.8149
COLO 858 Vemurafenib Trametinib Defactinib 0.1000 0.0100 1.0000
uM
 72
hr
 3 1045 844 0.0283 0.0295 0.8077 0.8149
COLO 858 Vemurafenib Trametinib Defactinib 0.1000 0.0100 3.1600
uM
 72
hr
 1 1138 1037 0.0142 0.0125 0.9112 0.9113
COLO 858 Vemurafenib Trametinib Defactinib 0.1000 0.0100 3.1600
uM
 72
hr
 2 1014 920 0.0132 0.0125 0.9073 0.9113
COLO 858 Vemurafenib Trametinib Defactinib 0.1000 0.0100 3.1600
uM
 72
hr
 3 852 780 0.0101 0.0125 0.9155 0.9113
COLO 858 Vemurafenib Trametinib Defactinib 0.3160 0.0316 0.0000
uM
 72
hr
 1 1367 855 0.0721 0.0704 0.6255 0.6512
COLO 858 Vemurafenib Trametinib Defactinib 0.3160 0.0316 0.0000
uM
 72
hr
 2 1453 971 0.0678 0.0704 0.6683 0.6512
COLO 858 Vemurafenib Trametinib Defactinib 0.3160 0.0316 0.0000
uM
 72
hr
 3 1488 982 0.0712 0.0704 0.6599 0.6512
COLO 858 Vemurafenib Trametinib Defactinib 0.3160 0.0316 0.3160
uM
 72
hr
 1 1201 965 0.0332 0.0310 0.8035 0.8160
COLO 858 Vemurafenib Trametinib Defactinib 0.3160 0.0316 0.3160
uM
 72
hr
 2 1154 921 0.0328 0.0310 0.7981 0.8160
COLO 858 Vemurafenib Trametinib Defactinib 0.3160 0.0316 0.3160
uM
 72
hr
 3 1251 1059 0.0270 0.0310 0.8465 0.8160
COLO 858 Vemurafenib Trametinib Defactinib 0.3160 0.0316 1.0000
uM
 72
hr
 1 1504 1272 0.0327 0.0247 0.8457 0.8594
COLO 858 Vemurafenib Trametinib Defactinib 0.3160 0.0316 1.0000
uM
 72
hr
 2 1218 1059 0.0224 0.0247 0.8695 0.8594
COLO 858 Vemurafenib Trametinib Defactinib 0.3160 0.0316 1.0000
uM
 72
hr
 3 985 850 0.0190 0.0247 0.8629 0.8594
COLO 858 Vemurafenib Trametinib Defactinib 0.3160 0.0316 3.1600
uM
 72
hr
 1 1106 1013 0.0131 0.0124 0.9159 0.9154
COLO 858 Vemurafenib Trametinib Defactinib 0.3160 0.0316 3.1600
uM
 72
hr
 2 980 921 0.0083 0.0124 0.9398 0.9154
COLO 858 Vemurafenib Trametinib Defactinib 0.3160 0.0316 3.1600
uM
 72
hr
 3 1031 918 0.0159 0.0124 0.8904 0.9154
COLO 858 Vemurafenib Trametinib Defactinib 1.0000 0.1000 0.0000
uM
 72
hr
 1 1299 1000 0.0421 0.0458 0.7698 0.7801
COLO 858 Vemurafenib Trametinib Defactinib 1.0000 0.1000 0.0000
uM
 72
hr
 2 1435 1146 0.0407 0.0458 0.7986 0.7801
COLO 858 Vemurafenib Trametinib Defactinib 1.0000 0.1000 0.0000
uM
 72
hr
 3 1706 1317 0.0548 0.0458 0.7720 0.7801
COLO 858 Vemurafenib Trametinib Defactinib 1.0000 0.1000 0.3160
uM
 72
hr
 1 1259 1096 0.0229 0.0182 0.8705 0.8837