Viability and apoptosis measured by imaging in BRAF(V600E/D) melanoma cell lines following treatment with combinations of three compounds (viability/apoptosis dataset 2 of 2) - Dataset (ID:20273)

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Cell Small Molecule 1 Small Molecule 2 Small Molecule 3 Small Mol 1 Concentration Small Mol 2 Concentration Small Mol 3 Concentration Small Mol Conc Unit Time Point Time Point Unit Replicate Total Number of Cells (Nuclei) Number of Apoptotic Cells Relative Viability Mean Relative Viability Apoptosis Fraction Mean Apoptosis Fraction
WM-115 Vemurafenib Trametinib Dasatinib 0.3160 0.0316 0.0000
uM
 72
hr
 2 2070 643 0.3346 0.3340 0.3106 0.3130
WM-115 Vemurafenib Trametinib Dasatinib 0.3160 0.0316 0.0000
uM
 72
hr
 3 2094 682 0.3311 0.3340 0.3257 0.3130
WM-115 Vemurafenib Trametinib Dasatinib 0.3160 0.0316 0.3160
uM
 72
hr
 1 1216 918 0.0699 0.0732 0.7549 0.7378
WM-115 Vemurafenib Trametinib Dasatinib 0.3160 0.0316 0.3160
uM
 72
hr
 2 1082 783 0.0701 0.0732 0.7237 0.7378
WM-115 Vemurafenib Trametinib Dasatinib 0.3160 0.0316 0.3160
uM
 72
hr
 3 1278 939 0.0795 0.0732 0.7347 0.7378
WM-115 Vemurafenib Trametinib Dasatinib 0.3160 0.0316 1.0000
uM
 72
hr
 1 1188 880 0.0722 0.0725 0.7407 0.7217
WM-115 Vemurafenib Trametinib Dasatinib 0.3160 0.0316 1.0000
uM
 72
hr
 2 1066 785 0.0659 0.0725 0.7364 0.7217
WM-115 Vemurafenib Trametinib Dasatinib 0.3160 0.0316 1.0000
uM
 72
hr
 3 1083 745 0.0792 0.0725 0.6879 0.7217
WM-115 Vemurafenib Trametinib Dasatinib 0.3160 0.0316 3.1600
uM
 72
hr
 1 1127 897 0.0539 0.0635 0.7959 0.7648
WM-115 Vemurafenib Trametinib Dasatinib 0.3160 0.0316 3.1600
uM
 72
hr
 2 1169 905 0.0619 0.0635 0.7742 0.7648
WM-115 Vemurafenib Trametinib Dasatinib 0.3160 0.0316 3.1600
uM
 72
hr
 3 1157 838 0.0748 0.0635 0.7243 0.7648
WM-115 Vemurafenib Trametinib Dasatinib 1.0000 0.1000 0.0000
uM
 72
hr
 1 1931 722 0.2835 0.2943 0.3739 0.3664
WM-115 Vemurafenib Trametinib Dasatinib 1.0000 0.1000 0.0000
uM
 72
hr
 2 2011 728 0.3008 0.2943 0.3620 0.3664
WM-115 Vemurafenib Trametinib Dasatinib 1.0000 0.1000 0.0000
uM
 72
hr
 3 2001 727 0.2987 0.2943 0.3633 0.3664
WM-115 Vemurafenib Trametinib Dasatinib 1.0000 0.1000 0.3160
uM
 72
hr
 1 1230 1017 0.0499 0.0513 0.8268 0.8042
WM-115 Vemurafenib Trametinib Dasatinib 1.0000 0.1000 0.3160
uM
 72
hr
 2 1201 992 0.0490 0.0513 0.8260 0.8042
WM-115 Vemurafenib Trametinib Dasatinib 1.0000 0.1000 0.3160
uM
 72
hr
 3 974 740 0.0549 0.0513 0.7598 0.8042
WM-115 Vemurafenib Trametinib Dasatinib 1.0000 0.1000 1.0000
uM
 72
hr
 1 1208 1013 0.0457 0.0475 0.8386 0.8251
WM-115 Vemurafenib Trametinib Dasatinib 1.0000 0.1000 1.0000
uM
 72
hr
 2 1102 908 0.0455 0.0475 0.8240 0.8251
WM-115 Vemurafenib Trametinib Dasatinib 1.0000 0.1000 1.0000
uM
 72
hr
 3 1170 951 0.0513 0.0475 0.8128 0.8251
WM-115 Vemurafenib Trametinib Dasatinib 1.0000 0.1000 3.1600
uM
 72
hr
 1 783 607 0.0413 0.0413 0.7752 0.7970
WM-115 Vemurafenib Trametinib Dasatinib 1.0000 0.1000 3.1600
uM
 72
hr
 2 872 714 0.0370 0.0413 0.8188 0.7970
WM-115 Vemurafenib Trametinib Dasatinib 1.0000 0.1000 3.1600
uM
 72
hr
 3 961 766 0.0457 0.0413 0.7971 0.7970
WM-115 Vemurafenib Trametinib Dasatinib 3.1600 0.3160 0.0000
uM
 72
hr
 1 1829 801 0.2410 0.2285 0.4379 0.4617
WM-115 Vemurafenib Trametinib Dasatinib 3.1600 0.3160 0.0000
uM
 72
hr
 2 1711 798 0.2141 0.2285 0.4664 0.4617