Viability and apoptosis measured by imaging in BRAF(V600E/D) melanoma cell lines following treatment with combinations of three compounds (viability/apoptosis dataset 2 of 2) - Dataset (ID:20273)

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Cell Small Molecule 1 Small Molecule 2 Small Molecule 3 Small Mol 1 Concentration Small Mol 2 Concentration Small Mol 3 Concentration Small Mol Conc Unit Time Point Time Point Unit Replicate Total Number of Cells (Nuclei) Number of Apoptotic Cells Relative Viability Mean Relative Viability Apoptosis Fraction Mean Apoptosis Fraction
COLO 858 Vemurafenib Trametinib Defactinib 1.0000 0.1000 0.3160
uM
 72
hr
 2 944 824 0.0169 0.0182 0.8729 0.8837
COLO 858 Vemurafenib Trametinib Defactinib 1.0000 0.1000 0.3160
uM
 72
hr
 3 1128 1024 0.0146 0.0182 0.9078 0.8837
COLO 858 Vemurafenib Trametinib Defactinib 1.0000 0.1000 1.0000
uM
 72
hr
 1 1549 1404 0.0204 0.0153 0.9064 0.9147
COLO 858 Vemurafenib Trametinib Defactinib 1.0000 0.1000 1.0000
uM
 72
hr
 2 1144 1058 0.0121 0.0153 0.9248 0.9147
COLO 858 Vemurafenib Trametinib Defactinib 1.0000 0.1000 1.0000
uM
 72
hr
 3 1102 1006 0.0135 0.0153 0.9129 0.9147
COLO 858 Vemurafenib Trametinib Defactinib 1.0000 0.1000 3.1600
uM
 72
hr
 1 860 805 0.0077 0.0101 0.9360 0.9205
COLO 858 Vemurafenib Trametinib Defactinib 1.0000 0.1000 3.1600
uM
 72
hr
 2 1001 920 0.0114 0.0101 0.9191 0.9205
COLO 858 Vemurafenib Trametinib Defactinib 1.0000 0.1000 3.1600
uM
 72
hr
 3 855 775 0.0113 0.0101 0.9064 0.9205
COLO 858 Vemurafenib Trametinib Defactinib 3.1600 0.3160 0.0000
uM
 72
hr
 1 1330 1201 0.0182 0.0136 0.9030 0.9358
COLO 858 Vemurafenib Trametinib Defactinib 3.1600 0.3160 0.0000
uM
 72
hr
 2 1636 1567 0.0097 0.0136 0.9578 0.9358
COLO 858 Vemurafenib Trametinib Defactinib 3.1600 0.3160 0.0000
uM
 72
hr
 3 1724 1632 0.0129 0.0136 0.9466 0.9358
COLO 858 Vemurafenib Trametinib Defactinib 3.1600 0.3160 0.3160
uM
 72
hr
 1 903 859 0.0062 0.0055 0.9513 0.9565
COLO 858 Vemurafenib Trametinib Defactinib 3.1600 0.3160 0.3160
uM
 72
hr
 2 972 934 0.0053 0.0055 0.9609 0.9565
COLO 858 Vemurafenib Trametinib Defactinib 3.1600 0.3160 0.3160
uM
 72
hr
 3 820 785 0.0049 0.0055 0.9573 0.9565
COLO 858 Vemurafenib Trametinib Defactinib 3.1600 0.3160 1.0000
uM
 72
hr
 1 1719 1644 0.0106 0.0087 0.9564 0.9527
COLO 858 Vemurafenib Trametinib Defactinib 3.1600 0.3160 1.0000
uM
 72
hr
 2 1240 1189 0.0072 0.0087 0.9589 0.9527
COLO 858 Vemurafenib Trametinib Defactinib 3.1600 0.3160 1.0000
uM
 72
hr
 3 1033 974 0.0083 0.0087 0.9429 0.9527
COLO 858 Vemurafenib Trametinib Defactinib 3.1600 0.3160 3.1600
uM
 72
hr
 1 958 901 0.0080 0.0069 0.9405 0.9329
COLO 858 Vemurafenib Trametinib Defactinib 3.1600 0.3160 3.1600
uM
 72
hr
 2 626 580 0.0065 0.0069 0.9265 0.9329
COLO 858 Vemurafenib Trametinib Defactinib 3.1600 0.3160 3.1600
uM
 72
hr
 3 643 599 0.0062 0.0069 0.9316 0.9329
COLO 858 Vemurafenib Trametinib JNK-IN-8 0.0000 0.0000 0.0000
uM
 72
hr
 1 7872 1111 1.0207 1.0000 0.1411 0.1414
COLO 858 Vemurafenib Trametinib JNK-IN-8 0.0000 0.0000 0.0000
uM
 72
hr
 2 8288 1188 1.0719 1.0000 0.1433 0.1414
COLO 858 Vemurafenib Trametinib JNK-IN-8 0.0000 0.0000 0.0000
uM
 72
hr
 3 6988 977 0.9075 1.0000 0.1398 0.1414
COLO 858 Vemurafenib Trametinib JNK-IN-8 0.0000 0.0000 0.3160
uM
 72
hr
 1 6430 927 0.8308 0.8479 0.1442 0.1394
COLO 858 Vemurafenib Trametinib JNK-IN-8 0.0000 0.0000 0.3160
uM
 72
hr
 2 6209 809 0.8152 0.8479 0.1303 0.1394