Viability and apoptosis measured by imaging in BRAF(V600E/D) melanoma cell lines following treatment with combinations of three compounds (viability/apoptosis dataset 2 of 2) - Dataset (ID:20273)

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Cell Small Molecule 1 Small Molecule 2 Small Molecule 3 Small Mol 1 Concentration Small Mol 2 Concentration Small Mol 3 Concentration Small Mol Conc Unit Time Point Time Point Unit Replicate Total Number of Cells (Nuclei) Number of Apoptotic Cells Relative Viability Mean Relative Viability Apoptosis Fraction Mean Apoptosis Fraction
MZ7-mel Vemurafenib Trametinib Defactinib 1.0000 0.1000 0.3160
uM
 72
hr
 2 1347 546 0.2377 0.2217 0.4053 0.4147
MZ7-mel Vemurafenib Trametinib Defactinib 1.0000 0.1000 0.3160
uM
 72
hr
 3 1464 620 0.2505 0.2217 0.4235 0.4147
MZ7-mel Vemurafenib Trametinib Defactinib 1.0000 0.1000 1.0000
uM
 72
hr
 1 1775 607 0.3466 0.2764 0.3420 0.3504
MZ7-mel Vemurafenib Trametinib Defactinib 1.0000 0.1000 1.0000
uM
 72
hr
 2 1677 565 0.3300 0.2764 0.3369 0.3504
MZ7-mel Vemurafenib Trametinib Defactinib 1.0000 0.1000 1.0000
uM
 72
hr
 3 819 305 0.1525 0.2764 0.3724 0.3504
MZ7-mel Vemurafenib Trametinib Defactinib 1.0000 0.1000 3.1600
uM
 72
hr
 1 1262 364 0.2665 0.2312 0.2884 0.3035
MZ7-mel Vemurafenib Trametinib Defactinib 1.0000 0.1000 3.1600
uM
 72
hr
 2 1258 392 0.2570 0.2312 0.3116 0.3035
MZ7-mel Vemurafenib Trametinib Defactinib 1.0000 0.1000 3.1600
uM
 72
hr
 3 831 258 0.1700 0.2312 0.3105 0.3035
MZ7-mel Vemurafenib Trametinib Defactinib 3.1600 0.3160 0.0000
uM
 72
hr
 1 1250 726 0.1555 0.2264 0.5808 0.5573
MZ7-mel Vemurafenib Trametinib Defactinib 3.1600 0.3160 0.0000
uM
 72
hr
 2 1790 969 0.2436 0.2264 0.5413 0.5573
MZ7-mel Vemurafenib Trametinib Defactinib 3.1600 0.3160 0.0000
uM
 72
hr
 3 2097 1153 0.2801 0.2264 0.5498 0.5573
MZ7-mel Vemurafenib Trametinib Defactinib 3.1600 0.3160 0.3160
uM
 72
hr
 1 734 326 0.1211 0.1162 0.4441 0.4480
MZ7-mel Vemurafenib Trametinib Defactinib 3.1600 0.3160 0.3160
uM
 72
hr
 2 641 287 0.1051 0.1162 0.4477 0.4480
MZ7-mel Vemurafenib Trametinib Defactinib 3.1600 0.3160 0.3160
uM
 72
hr
 3 754 341 0.1226 0.1162 0.4523 0.4480
MZ7-mel Vemurafenib Trametinib Defactinib 3.1600 0.3160 1.0000
uM
 72
hr
 1 2077 835 0.3686 0.2576 0.4020 0.3915
MZ7-mel Vemurafenib Trametinib Defactinib 3.1600 0.3160 1.0000
uM
 72
hr
 2 1459 547 0.2706 0.2576 0.3749 0.3915
MZ7-mel Vemurafenib Trametinib Defactinib 3.1600 0.3160 1.0000
uM
 72
hr
 3 747 297 0.1335 0.2576 0.3976 0.3915
MZ7-mel Vemurafenib Trametinib Defactinib 3.1600 0.3160 3.1600
uM
 72
hr
 1 815 239 0.1709 0.1687 0.2933 0.2871
MZ7-mel Vemurafenib Trametinib Defactinib 3.1600 0.3160 3.1600
uM
 72
hr
 2 737 194 0.1611 0.1687 0.2632 0.2871
MZ7-mel Vemurafenib Trametinib Defactinib 3.1600 0.3160 3.1600
uM
 72
hr
 3 843 257 0.1739 0.1687 0.3049 0.2871
MZ7-mel Vemurafenib Trametinib JNK-IN-8 0.0000 0.0000 0.0000
uM
 72
hr
 1 4116 261 1.0160 1.0000 0.0634 0.0629
MZ7-mel Vemurafenib Trametinib JNK-IN-8 0.0000 0.0000 0.0000
uM
 72
hr
 2 4238 295 1.0392 1.0000 0.0696 0.0629
MZ7-mel Vemurafenib Trametinib JNK-IN-8 0.0000 0.0000 0.0000
uM
 72
hr
 3 3796 211 0.9448 1.0000 0.0556 0.0629
MZ7-mel Vemurafenib Trametinib JNK-IN-8 0.0000 0.0000 0.3160
uM
 72
hr
 1 3851 235 0.9530 1.4250 0.0610 0.0566
MZ7-mel Vemurafenib Trametinib JNK-IN-8 0.0000 0.0000 0.3160
uM
 72
hr
 2 6532 380 1.6214 1.4250 0.0582 0.0566