Viability and apoptosis measured by imaging in BRAF(V600E/D) melanoma cell lines following treatment with combinations of three compounds (viability/apoptosis dataset 2 of 2) - Dataset (ID:20273)

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Cell Small Molecule 1 Small Molecule 2 Small Molecule 3 Small Mol 1 Concentration Small Mol 2 Concentration Small Mol 3 Concentration Small Mol Conc Unit Time Point Time Point Unit Replicate Total Number of Cells (Nuclei) Number of Apoptotic Cells Relative Viability Mean Relative Viability Apoptosis Fraction Mean Apoptosis Fraction
MZ7-mel Vemurafenib Trametinib Defactinib 0.1000 0.0100 0.3160
uM
 72
hr
 1 1288 441 0.2514 0.3256 0.3424 0.3226
MZ7-mel Vemurafenib Trametinib Defactinib 0.1000 0.0100 0.3160
uM
 72
hr
 2 1763 557 0.3579 0.3256 0.3159 0.3226
MZ7-mel Vemurafenib Trametinib Defactinib 0.1000 0.0100 0.3160
uM
 72
hr
 3 1793 555 0.3674 0.3256 0.3095 0.3226
MZ7-mel Vemurafenib Trametinib Defactinib 0.1000 0.0100 1.0000
uM
 72
hr
 1 1494 381 0.3303 0.2520 0.2550 0.2585
MZ7-mel Vemurafenib Trametinib Defactinib 0.1000 0.0100 1.0000
uM
 72
hr
 2 1239 310 0.2757 0.2520 0.2502 0.2585
MZ7-mel Vemurafenib Trametinib Defactinib 0.1000 0.0100 1.0000
uM
 72
hr
 3 692 187 0.1499 0.2520 0.2702 0.2585
MZ7-mel Vemurafenib Trametinib Defactinib 0.1000 0.0100 3.1600
uM
 72
hr
 1 1773 410 0.4045 0.3046 0.2312 0.2351
MZ7-mel Vemurafenib Trametinib Defactinib 0.1000 0.0100 3.1600
uM
 72
hr
 2 1497 347 0.3413 0.3046 0.2318 0.2351
MZ7-mel Vemurafenib Trametinib Defactinib 0.1000 0.0100 3.1600
uM
 72
hr
 3 747 181 0.1680 0.3046 0.2423 0.2351
MZ7-mel Vemurafenib Trametinib Defactinib 0.3160 0.0316 0.0000
uM
 72
hr
 1 939 406 0.1582 0.2282 0.4324 0.4565
MZ7-mel Vemurafenib Trametinib Defactinib 0.3160 0.0316 0.0000
uM
 72
hr
 2 1541 742 0.2371 0.2282 0.4815 0.4565
MZ7-mel Vemurafenib Trametinib Defactinib 0.3160 0.0316 0.0000
uM
 72
hr
 3 1791 816 0.2893 0.2282 0.4556 0.4565
MZ7-mel Vemurafenib Trametinib Defactinib 0.3160 0.0316 0.3160
uM
 72
hr
 1 1097 439 0.1953 0.2650 0.4002 0.3914
MZ7-mel Vemurafenib Trametinib Defactinib 0.3160 0.0316 0.3160
uM
 72
hr
 2 1500 592 0.2695 0.2650 0.3947 0.3914
MZ7-mel Vemurafenib Trametinib Defactinib 0.3160 0.0316 0.3160
uM
 72
hr
 3 1793 680 0.3303 0.2650 0.3793 0.3914
MZ7-mel Vemurafenib Trametinib Defactinib 0.3160 0.0316 1.0000
uM
 72
hr
 1 1677 548 0.3350 0.2548 0.3268 0.3225
MZ7-mel Vemurafenib Trametinib Defactinib 0.3160 0.0316 1.0000
uM
 72
hr
 2 1336 438 0.2665 0.2548 0.3278 0.3225
MZ7-mel Vemurafenib Trametinib Defactinib 0.3160 0.0316 1.0000
uM
 72
hr
 3 799 250 0.1629 0.2548 0.3129 0.3225
MZ7-mel Vemurafenib Trametinib Defactinib 0.3160 0.0316 3.1600
uM
 72
hr
 1 1495 448 0.3107 0.2565 0.2997 0.3057
MZ7-mel Vemurafenib Trametinib Defactinib 0.3160 0.0316 3.1600
uM
 72
hr
 2 1429 425 0.2980 0.2565 0.2974 0.3057
MZ7-mel Vemurafenib Trametinib Defactinib 0.3160 0.0316 3.1600
uM
 72
hr
 3 797 255 0.1608 0.2565 0.3199 0.3057
MZ7-mel Vemurafenib Trametinib Defactinib 1.0000 0.1000 0.0000
uM
 72
hr
 1 1310 643 0.1979 0.2655 0.4908 0.4969
MZ7-mel Vemurafenib Trametinib Defactinib 1.0000 0.1000 0.0000
uM
 72
hr
 2 1994 1051 0.2798 0.2655 0.5271 0.4969
MZ7-mel Vemurafenib Trametinib Defactinib 1.0000 0.1000 0.0000
uM
 72
hr
 3 2037 963 0.3187 0.2655 0.4728 0.4969
MZ7-mel Vemurafenib Trametinib Defactinib 1.0000 0.1000 0.3160
uM
 72
hr
 1 1019 423 0.1769 0.2217 0.4151 0.4147