Viability and apoptosis measured by imaging in BRAF(V600E/D) melanoma cell lines following treatment with combinations of three compounds (viability/apoptosis dataset 2 of 2) - Dataset (ID:20273)

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Cell Small Molecule 1 Small Molecule 2 Small Molecule 3 Small Mol 1 Concentration Small Mol 2 Concentration Small Mol 3 Concentration Small Mol Conc Unit Time Point Time Point Unit Replicate Total Number of Cells (Nuclei) Number of Apoptotic Cells Relative Viability Mean Relative Viability Apoptosis Fraction Mean Apoptosis Fraction
MMAC-SF Vemurafenib Trametinib JNK-IN-8 0.0000 0.0000 0.3160
uM
 72
hr
 3 1446 46 1.3861 1.3106 0.0318 0.0383
MMAC-SF Vemurafenib Trametinib JNK-IN-8 0.0000 0.0000 1.0000
uM
 72
hr
 1 814 37 0.7693 0.6713 0.0455 0.0438
MMAC-SF Vemurafenib Trametinib JNK-IN-8 0.0000 0.0000 1.0000
uM
 72
hr
 2 735 34 0.6941 0.6713 0.0463 0.0438
MMAC-SF Vemurafenib Trametinib JNK-IN-8 0.0000 0.0000 1.0000
uM
 72
hr
 3 579 23 0.5505 0.6713 0.0397 0.0438
MMAC-SF Vemurafenib Trametinib JNK-IN-8 0.0000 0.0000 3.1600
uM
 72
hr
 1 1032 48 0.9743 0.7059 0.0465 0.0474
MMAC-SF Vemurafenib Trametinib JNK-IN-8 0.0000 0.0000 3.1600
uM
 72
hr
 2 684 37 0.6406 0.7059 0.0541 0.0474
MMAC-SF Vemurafenib Trametinib JNK-IN-8 0.0000 0.0000 3.1600
uM
 72
hr
 3 530 22 0.5030 0.7059 0.0415 0.0474
MMAC-SF Vemurafenib Trametinib JNK-IN-8 0.1000 0.0100 0.0000
uM
 72
hr
 1 638 221 0.4129 0.3924 0.3464 0.3351
MMAC-SF Vemurafenib Trametinib JNK-IN-8 0.1000 0.0100 0.0000
uM
 72
hr
 2 521 179 0.3386 0.3924 0.3436 0.3351
MMAC-SF Vemurafenib Trametinib JNK-IN-8 0.1000 0.0100 0.0000
uM
 72
hr
 3 628 198 0.4257 0.3924 0.3153 0.3351
MMAC-SF Vemurafenib Trametinib JNK-IN-8 0.1000 0.0100 0.3160
uM
 72
hr
 1 799 264 0.5297 0.5696 0.3304 0.3054
MMAC-SF Vemurafenib Trametinib JNK-IN-8 0.1000 0.0100 0.3160
uM
 72
hr
 2 897 272 0.6188 0.5696 0.3032 0.3054
MMAC-SF Vemurafenib Trametinib JNK-IN-8 0.1000 0.0100 0.3160
uM
 72
hr
 3 789 223 0.5604 0.5696 0.2826 0.3054
MMAC-SF Vemurafenib Trametinib JNK-IN-8 0.1000 0.0100 1.0000
uM
 72
hr
 1 698 175 0.5178 0.4300 0.2507 0.2490
MMAC-SF Vemurafenib Trametinib JNK-IN-8 0.1000 0.0100 1.0000
uM
 72
hr
 2 619 148 0.4663 0.4300 0.2391 0.2490
MMAC-SF Vemurafenib Trametinib JNK-IN-8 0.1000 0.0100 1.0000
uM
 72
hr
 3 416 107 0.3059 0.4300 0.2572 0.2490
MMAC-SF Vemurafenib Trametinib JNK-IN-8 0.1000 0.0100 3.1600
uM
 72
hr
 1 687 172 0.5099 0.4370 0.2504 0.2386
MMAC-SF Vemurafenib Trametinib JNK-IN-8 0.1000 0.0100 3.1600
uM
 72
hr
 2 609 138 0.4663 0.4370 0.2266 0.2386
MMAC-SF Vemurafenib Trametinib JNK-IN-8 0.1000 0.0100 3.1600
uM
 72
hr
 3 444 106 0.3347 0.4370 0.2387 0.2386
MMAC-SF Vemurafenib Trametinib JNK-IN-8 0.3160 0.0316 0.0000
uM
 72
hr
 1 595 247 0.3446 0.3640 0.4151 0.3926
MMAC-SF Vemurafenib Trametinib JNK-IN-8 0.3160 0.0316 0.0000
uM
 72
hr
 2 589 228 0.3574 0.3640 0.3871 0.3926
MMAC-SF Vemurafenib Trametinib JNK-IN-8 0.3160 0.0316 0.0000
uM
 72
hr
 3 631 237 0.3901 0.3640 0.3756 0.3926
MMAC-SF Vemurafenib Trametinib JNK-IN-8 0.3160 0.0316 0.3160
uM
 72
hr
 1 698 248 0.4455 0.4875 0.3553 0.3407
MMAC-SF Vemurafenib Trametinib JNK-IN-8 0.3160 0.0316 0.3160
uM
 72
hr
 2 793 258 0.5297 0.4875 0.3253 0.3407
MMAC-SF Vemurafenib Trametinib JNK-IN-8 0.3160 0.0316 0.3160
uM
 72
hr
 3 747 255 0.4871 0.4875 0.3414 0.3407