Viability and apoptosis measured by imaging in BRAF(V600E/D) melanoma cell lines following treatment with combinations of three compounds (viability/apoptosis dataset 2 of 2) - Dataset (ID:20273)

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Cell Small Molecule 1 Small Molecule 2 Small Molecule 3 Small Mol 1 Concentration Small Mol 2 Concentration Small Mol 3 Concentration Small Mol Conc Unit Time Point Time Point Unit Replicate Total Number of Cells (Nuclei) Number of Apoptotic Cells Relative Viability Mean Relative Viability Apoptosis Fraction Mean Apoptosis Fraction
MMAC-SF Vemurafenib Trametinib Defactinib 1.0000 0.1000 0.3160
uM
 72
hr
 2 457 209 0.2395 0.2478 0.4573 0.4332
MMAC-SF Vemurafenib Trametinib Defactinib 1.0000 0.1000 0.3160
uM
 72
hr
 3 471 200 0.2617 0.2478 0.4246 0.4332
MMAC-SF Vemurafenib Trametinib Defactinib 1.0000 0.1000 1.0000
uM
 72
hr
 1 503 213 0.2800 0.2053 0.4235 0.4547
MMAC-SF Vemurafenib Trametinib Defactinib 1.0000 0.1000 1.0000
uM
 72
hr
 2 376 167 0.2018 0.2053 0.4441 0.4547
MMAC-SF Vemurafenib Trametinib Defactinib 1.0000 0.1000 1.0000
uM
 72
hr
 3 276 137 0.1342 0.2053 0.4964 0.4547
MMAC-SF Vemurafenib Trametinib Defactinib 1.0000 0.1000 3.1600
uM
 72
hr
 1 376 183 0.1864 0.1361 0.4867 0.5198
MMAC-SF Vemurafenib Trametinib Defactinib 1.0000 0.1000 3.1600
uM
 72
hr
 2 292 144 0.1429 0.1361 0.4932 0.5198
MMAC-SF Vemurafenib Trametinib Defactinib 1.0000 0.1000 3.1600
uM
 72
hr
 3 195 113 0.0792 0.1361 0.5795 0.5198
MMAC-SF Vemurafenib Trametinib Defactinib 3.1600 0.3160 0.0000
uM
 72
hr
 1 495 199 0.2858 0.2955 0.4020 0.4057
MMAC-SF Vemurafenib Trametinib Defactinib 3.1600 0.3160 0.0000
uM
 72
hr
 2 474 190 0.2742 0.2955 0.4008 0.4057
MMAC-SF Vemurafenib Trametinib Defactinib 3.1600 0.3160 0.0000
uM
 72
hr
 3 577 239 0.3264 0.2955 0.4142 0.4057
MMAC-SF Vemurafenib Trametinib Defactinib 3.1600 0.3160 0.3160
uM
 72
hr
 1 294 114 0.1738 0.1625 0.3878 0.4050
MMAC-SF Vemurafenib Trametinib Defactinib 3.1600 0.3160 0.3160
uM
 72
hr
 2 268 113 0.1497 0.1625 0.4216 0.4050
MMAC-SF Vemurafenib Trametinib Defactinib 3.1600 0.3160 0.3160
uM
 72
hr
 3 286 116 0.1641 0.1625 0.4056 0.4050
MMAC-SF Vemurafenib Trametinib Defactinib 3.1600 0.3160 1.0000
uM
 72
hr
 1 471 182 0.2790 0.1986 0.3864 0.4158
MMAC-SF Vemurafenib Trametinib Defactinib 3.1600 0.3160 1.0000
uM
 72
hr
 2 356 158 0.1912 0.1986 0.4438 0.4158
MMAC-SF Vemurafenib Trametinib Defactinib 3.1600 0.3160 1.0000
uM
 72
hr
 3 223 93 0.1255 0.1986 0.4170 0.4158
MMAC-SF Vemurafenib Trametinib Defactinib 3.1600 0.3160 3.1600
uM
 72
hr
 1 286 117 0.1632 0.1361 0.4091 0.3969
MMAC-SF Vemurafenib Trametinib Defactinib 3.1600 0.3160 3.1600
uM
 72
hr
 2 218 79 0.1342 0.1361 0.3624 0.3969
MMAC-SF Vemurafenib Trametinib Defactinib 3.1600 0.3160 3.1600
uM
 72
hr
 3 198 83 0.1110 0.1361 0.4192 0.3969
MMAC-SF Vemurafenib Trametinib JNK-IN-8 0.0000 0.0000 0.0000
uM
 72
hr
 1 1042 48 0.9842 1.0000 0.0461 0.0533
MMAC-SF Vemurafenib Trametinib JNK-IN-8 0.0000 0.0000 0.0000
uM
 72
hr
 2 1102 62 1.0297 1.0000 0.0563 0.0533
MMAC-SF Vemurafenib Trametinib JNK-IN-8 0.0000 0.0000 0.0000
uM
 72
hr
 3 1057 61 0.9861 1.0000 0.0577 0.0533
MMAC-SF Vemurafenib Trametinib JNK-IN-8 0.0000 0.0000 0.3160
uM
 72
hr
 1 1293 49 1.2317 1.3106 0.0379 0.0383
MMAC-SF Vemurafenib Trametinib JNK-IN-8 0.0000 0.0000 0.3160
uM
 72
hr
 2 1390 63 1.3139 1.3106 0.0453 0.0383