Viability and apoptosis measured by imaging in BRAF(V600E/D) melanoma cell lines following treatment with combinations of three compounds (viability/apoptosis dataset 2 of 2) - Dataset (ID:20273)

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Cell Small Molecule 1 Small Molecule 2 Small Molecule 3 Small Mol 1 Concentration Small Mol 2 Concentration Small Mol 3 Concentration Small Mol Conc Unit Time Point Time Point Unit Replicate Total Number of Cells (Nuclei) Number of Apoptotic Cells Relative Viability Mean Relative Viability Apoptosis Fraction Mean Apoptosis Fraction
MZ7-mel Vemurafenib Trametinib JNK-IN-8 0.0000 0.0000 0.3160
uM
 72
hr
 3 6798 345 1.7007 1.4250 0.0508 0.0566
MZ7-mel Vemurafenib Trametinib JNK-IN-8 0.0000 0.0000 1.0000
uM
 72
hr
 1 4085 200 1.0239 0.9208 0.0490 0.0457
MZ7-mel Vemurafenib Trametinib JNK-IN-8 0.0000 0.0000 1.0000
uM
 72
hr
 2 3923 164 0.9907 0.9208 0.0418 0.0457
MZ7-mel Vemurafenib Trametinib JNK-IN-8 0.0000 0.0000 1.0000
uM
 72
hr
 3 2976 138 0.7480 0.9208 0.0464 0.0457
MZ7-mel Vemurafenib Trametinib JNK-IN-8 0.0000 0.0000 3.1600
uM
 72
hr
 1 5474 256 1.3752 0.9655 0.0468 0.0440
MZ7-mel Vemurafenib Trametinib JNK-IN-8 0.0000 0.0000 3.1600
uM
 72
hr
 2 3564 170 0.8945 0.9655 0.0477 0.0440
MZ7-mel Vemurafenib Trametinib JNK-IN-8 0.0000 0.0000 3.1600
uM
 72
hr
 3 2471 93 0.6267 0.9655 0.0376 0.0440
MZ7-mel Vemurafenib Trametinib JNK-IN-8 0.1000 0.0100 0.0000
uM
 72
hr
 1 1183 328 0.2253 0.2508 0.2773 0.2859
MZ7-mel Vemurafenib Trametinib JNK-IN-8 0.1000 0.0100 0.0000
uM
 72
hr
 2 1380 377 0.2643 0.2508 0.2732 0.2859
MZ7-mel Vemurafenib Trametinib JNK-IN-8 0.1000 0.0100 0.0000
uM
 72
hr
 3 1439 442 0.2628 0.2508 0.3072 0.2859
MZ7-mel Vemurafenib Trametinib JNK-IN-8 0.1000 0.0100 0.3160
uM
 72
hr
 1 1541 370 0.3086 0.3204 0.2401 0.2295
MZ7-mel Vemurafenib Trametinib JNK-IN-8 0.1000 0.0100 0.3160
uM
 72
hr
 2 1589 408 0.3113 0.3204 0.2568 0.2295
MZ7-mel Vemurafenib Trametinib JNK-IN-8 0.1000 0.0100 0.3160
uM
 72
hr
 3 1602 307 0.3413 0.3204 0.1916 0.2295
MZ7-mel Vemurafenib Trametinib JNK-IN-8 0.1000 0.0100 1.0000
uM
 72
hr
 1 1427 341 0.2862 0.2238 0.2390 0.2477
MZ7-mel Vemurafenib Trametinib JNK-IN-8 0.1000 0.0100 1.0000
uM
 72
hr
 2 1067 254 0.2143 0.2238 0.2381 0.2477
MZ7-mel Vemurafenib Trametinib JNK-IN-8 0.1000 0.0100 1.0000
uM
 72
hr
 3 883 235 0.1708 0.2238 0.2661 0.2477
MZ7-mel Vemurafenib Trametinib JNK-IN-8 0.1000 0.0100 3.1600
uM
 72
hr
 1 1619 508 0.2928 0.2218 0.3138 0.3251
MZ7-mel Vemurafenib Trametinib JNK-IN-8 0.1000 0.0100 3.1600
uM
 72
hr
 2 1298 405 0.2354 0.2218 0.3120 0.3251
MZ7-mel Vemurafenib Trametinib JNK-IN-8 0.1000 0.0100 3.1600
uM
 72
hr
 3 801 280 0.1373 0.2218 0.3496 0.3251
MZ7-mel Vemurafenib Trametinib JNK-IN-8 0.3160 0.0316 0.0000
uM
 72
hr
 1 1345 478 0.2285 0.2577 0.3554 0.3715
MZ7-mel Vemurafenib Trametinib JNK-IN-8 0.3160 0.0316 0.0000
uM
 72
hr
 2 1645 619 0.2704 0.2577 0.3763 0.3715
MZ7-mel Vemurafenib Trametinib JNK-IN-8 0.3160 0.0316 0.0000
uM
 72
hr
 3 1685 645 0.2741 0.2577 0.3828 0.3715
MZ7-mel Vemurafenib Trametinib JNK-IN-8 0.3160 0.0316 0.3160
uM
 72
hr
 1 1464 498 0.2546 0.2676 0.3402 0.3238
MZ7-mel Vemurafenib Trametinib JNK-IN-8 0.3160 0.0316 0.3160
uM
 72
hr
 2 1602 530 0.2825 0.2676 0.3308 0.3238
MZ7-mel Vemurafenib Trametinib JNK-IN-8 0.3160 0.0316 0.3160
uM
 72
hr
 3 1441 433 0.2657 0.2676 0.3005 0.3238