Viability and apoptosis measured by imaging in BRAF(V600E/D) melanoma cell lines following treatment with combinations of three compounds (viability/apoptosis dataset 2 of 2) - Dataset (ID:20273)

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Cell Small Molecule 1 Small Molecule 2 Small Molecule 3 Small Mol 1 Concentration Small Mol 2 Concentration Small Mol 3 Concentration Small Mol Conc Unit Time Point Time Point Unit Replicate Total Number of Cells (Nuclei) Number of Apoptotic Cells Relative Viability Mean Relative Viability Apoptosis Fraction Mean Apoptosis Fraction
WM-115 Vemurafenib Trametinib PF562271 1.0000 0.1000 3.1600
uM
 72
hr
 1 1177 525 0.1595 0.1676 0.4460 0.4009
WM-115 Vemurafenib Trametinib PF562271 1.0000 0.1000 3.1600
uM
 72
hr
 2 1148 427 0.1763 0.1676 0.3720 0.4009
WM-115 Vemurafenib Trametinib PF562271 1.0000 0.1000 3.1600
uM
 72
hr
 3 1110 427 0.1670 0.1676 0.3847 0.4009
WM-115 Vemurafenib Trametinib PF562271 3.1600 0.3160 0.0000
uM
 72
hr
 1 1784 933 0.2081 0.2020 0.5230 0.5127
WM-115 Vemurafenib Trametinib PF562271 3.1600 0.3160 0.0000
uM
 72
hr
 2 1550 773 0.1900 0.2020 0.4987 0.5127
WM-115 Vemurafenib Trametinib PF562271 3.1600 0.3160 0.0000
uM
 72
hr
 3 1758 908 0.2079 0.2020 0.5165 0.5127
WM-115 Vemurafenib Trametinib PF562271 3.1600 0.3160 0.3160
uM
 72
hr
 1 1357 770 0.1436 0.1469 0.5674 0.5450
WM-115 Vemurafenib Trametinib PF562271 3.1600 0.3160 0.3160
uM
 72
hr
 2 1309 727 0.1423 0.1469 0.5554 0.5450
WM-115 Vemurafenib Trametinib PF562271 3.1600 0.3160 0.3160
uM
 72
hr
 3 1298 665 0.1548 0.1469 0.5123 0.5450
WM-115 Vemurafenib Trametinib PF562271 3.1600 0.3160 1.0000
uM
 72
hr
 1 1409 760 0.1587 0.1491 0.5394 0.5301
WM-115 Vemurafenib Trametinib PF562271 3.1600 0.3160 1.0000
uM
 72
hr
 2 1295 708 0.1436 0.1491 0.5467 0.5301
WM-115 Vemurafenib Trametinib PF562271 3.1600 0.3160 1.0000
uM
 72
hr
 3 1196 603 0.1450 0.1491 0.5042 0.5301
WM-115 Vemurafenib Trametinib PF562271 3.1600 0.3160 3.1600
uM
 72
hr
 1 1135 515 0.1516 0.1437 0.4537 0.4715
WM-115 Vemurafenib Trametinib PF562271 3.1600 0.3160 3.1600
uM
 72
hr
 2 1136 503 0.1548 0.1437 0.4428 0.4715
WM-115 Vemurafenib Trametinib PF562271 3.1600 0.3160 3.1600
uM
 72
hr
 3 1058 548 0.1247 0.1437 0.5180 0.4715
WM-115 Vemurafenib Trametinib Saracatinib 0.0000 0.0000 0.0000
uM
 72
hr
 1 4067 247 1.0082 1.0000 0.0607 0.0605
WM-115 Vemurafenib Trametinib Saracatinib 0.0000 0.0000 0.0000
uM
 72
hr
 2 4088 253 1.0121 1.0000 0.0619 0.0605
WM-115 Vemurafenib Trametinib Saracatinib 0.0000 0.0000 0.0000
uM
 72
hr
 3 3944 232 0.9797 1.0000 0.0588 0.0605
WM-115 Vemurafenib Trametinib Saracatinib 0.0000 0.0000 0.3160
uM
 72
hr
 1 3549 278 0.8633 0.9124 0.0783 0.0746
WM-115 Vemurafenib Trametinib Saracatinib 0.0000 0.0000 0.3160
uM
 72
hr
 2 3720 267 0.9113 0.9124 0.0718 0.0746
WM-115 Vemurafenib Trametinib Saracatinib 0.0000 0.0000 0.3160
uM
 72
hr
 3 3937 290 0.9625 0.9124 0.0737 0.0746
WM-115 Vemurafenib Trametinib Saracatinib 0.0000 0.0000 1.0000
uM
 72
hr
 1 3654 265 0.8944 0.8396 0.0725 0.0716
WM-115 Vemurafenib Trametinib Saracatinib 0.0000 0.0000 1.0000
uM
 72
hr
 2 3321 260 0.8079 0.8396 0.0783 0.0716
WM-115 Vemurafenib Trametinib Saracatinib 0.0000 0.0000 1.0000
uM
 72
hr
 3 3306 212 0.8166 0.8396 0.0641 0.0716
WM-115 Vemurafenib Trametinib Saracatinib 0.0000 0.0000 3.1600
uM
 72
hr
 1 3249 292 0.7804 0.7205 0.0899 0.0832