Viability and apoptosis measured by imaging in BRAF(V600E/D) melanoma cell lines following treatment with combinations of three compounds (viability/apoptosis dataset 2 of 2) - Dataset (ID:20273)

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Cell Small Molecule 1 Small Molecule 2 Small Molecule 3 Small Mol 1 Concentration Small Mol 2 Concentration Small Mol 3 Concentration Small Mol Conc Unit Time Point Time Point Unit Replicate Total Number of Cells (Nuclei) Number of Apoptotic Cells Relative Viability Mean Relative Viability Apoptosis Fraction Mean Apoptosis Fraction
WM-115 Vemurafenib Trametinib PF562271 0.1000 0.0100 1.0000
uM
 72
hr
 3 1411 440 0.2375 0.2360 0.3118 0.3345
WM-115 Vemurafenib Trametinib PF562271 0.1000 0.0100 3.1600
uM
 72
hr
 1 1375 556 0.2003 0.2024 0.4044 0.3743
WM-115 Vemurafenib Trametinib PF562271 0.1000 0.0100 3.1600
uM
 72
hr
 2 1358 519 0.2052 0.2024 0.3822 0.3743
WM-115 Vemurafenib Trametinib PF562271 0.1000 0.0100 3.1600
uM
 72
hr
 3 1243 418 0.2018 0.2024 0.3363 0.3743
WM-115 Vemurafenib Trametinib PF562271 0.3160 0.0316 0.0000
uM
 72
hr
 1 1868 585 0.3138 0.3060 0.3132 0.3496
WM-115 Vemurafenib Trametinib PF562271 0.3160 0.0316 0.0000
uM
 72
hr
 2 1924 677 0.3050 0.3060 0.3519 0.3496
WM-115 Vemurafenib Trametinib PF562271 0.3160 0.0316 0.0000
uM
 72
hr
 3 1986 762 0.2993 0.3060 0.3837 0.3496
WM-115 Vemurafenib Trametinib PF562271 0.3160 0.0316 0.3160
uM
 72
hr
 1 1679 712 0.2365 0.2149 0.4241 0.4525
WM-115 Vemurafenib Trametinib PF562271 0.3160 0.0316 0.3160
uM
 72
hr
 2 1567 731 0.2045 0.2149 0.4665 0.4525
WM-115 Vemurafenib Trametinib PF562271 0.3160 0.0316 0.3160
uM
 72
hr
 3 1563 730 0.2037 0.2149 0.4671 0.4525
WM-115 Vemurafenib Trametinib PF562271 0.3160 0.0316 1.0000
uM
 72
hr
 1 1415 568 0.2071 0.2054 0.4014 0.4073
WM-115 Vemurafenib Trametinib PF562271 0.3160 0.0316 1.0000
uM
 72
hr
 2 1450 585 0.2115 0.2054 0.4034 0.4073
WM-115 Vemurafenib Trametinib PF562271 0.3160 0.0316 1.0000
uM
 72
hr
 3 1386 578 0.1976 0.2054 0.4170 0.4073
WM-115 Vemurafenib Trametinib PF562271 0.3160 0.0316 3.1600
uM
 72
hr
 1 1342 577 0.1871 0.1893 0.4300 0.4117
WM-115 Vemurafenib Trametinib PF562271 0.3160 0.0316 3.1600
uM
 72
hr
 2 1318 547 0.1886 0.1893 0.4150 0.4117
WM-115 Vemurafenib Trametinib PF562271 0.3160 0.0316 3.1600
uM
 72
hr
 3 1289 503 0.1922 0.1893 0.3902 0.4117
WM-115 Vemurafenib Trametinib PF562271 1.0000 0.1000 0.0000
uM
 72
hr
 1 1808 751 0.2585 0.2671 0.4154 0.4153
WM-115 Vemurafenib Trametinib PF562271 1.0000 0.1000 0.0000
uM
 72
hr
 2 1937 769 0.2856 0.2671 0.3970 0.4153
WM-115 Vemurafenib Trametinib PF562271 1.0000 0.1000 0.0000
uM
 72
hr
 3 1855 804 0.2570 0.2671 0.4334 0.4153
WM-115 Vemurafenib Trametinib PF562271 1.0000 0.1000 0.3160
uM
 72
hr
 1 1596 790 0.1971 0.1963 0.4950 0.4591
WM-115 Vemurafenib Trametinib PF562271 1.0000 0.1000 0.3160
uM
 72
hr
 2 1423 606 0.1998 0.1963 0.4259 0.4591
WM-115 Vemurafenib Trametinib PF562271 1.0000 0.1000 0.3160
uM
 72
hr
 3 1444 659 0.1920 0.1963 0.4564 0.4591
WM-115 Vemurafenib Trametinib PF562271 1.0000 0.1000 1.0000
uM
 72
hr
 1 1582 791 0.1934 0.1842 0.5000 0.4768
WM-115 Vemurafenib Trametinib PF562271 1.0000 0.1000 1.0000
uM
 72
hr
 2 1421 685 0.1800 0.1842 0.4821 0.4768
WM-115 Vemurafenib Trametinib PF562271 1.0000 0.1000 1.0000
uM
 72
hr
 3 1327 595 0.1790 0.1842 0.4484 0.4768