Viability and apoptosis measured by imaging in BRAF(V600E/D) melanoma cell lines following treatment with combinations of three compounds (viability/apoptosis dataset 2 of 2) - Dataset (ID:20273)
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Cell | Small Molecule 1 | Small Molecule 2 | Small Molecule 3 | Small Mol 1 Concentration | Small Mol 2 Concentration | Small Mol 3 Concentration | Small Mol Conc Unit | Time Point | Time Point Unit | Replicate | Total Number of Cells (Nuclei) | Number of Apoptotic Cells | Relative Viability | Mean Relative Viability | Apoptosis Fraction | Mean Apoptosis Fraction |
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A-375 | Vemurafenib | Trametinib | Saracatinib | 0.0000 | 0.0000 | 3.1600 | uM | 72 | hr | 2 | 6743 | 305 | 0.3824 | 0.3895 | 0.0452 | 0.0403 |
A-375 | Vemurafenib | Trametinib | Saracatinib | 0.0000 | 0.0000 | 3.1600 | uM | 72 | hr | 3 | 4796 | 182 | 0.2741 | 0.3895 | 0.0379 | 0.0403 |
A-375 | Vemurafenib | Trametinib | Saracatinib | 0.1000 | 0.0100 | 0.0000 | uM | 72 | hr | 1 | 2318 | 206 | 0.1255 | 0.1286 | 0.0889 | 0.0918 |
A-375 | Vemurafenib | Trametinib | Saracatinib | 0.1000 | 0.0100 | 0.0000 | uM | 72 | hr | 2 | 2374 | 218 | 0.1281 | 0.1286 | 0.0918 | 0.0918 |
A-375 | Vemurafenib | Trametinib | Saracatinib | 0.1000 | 0.0100 | 0.0000 | uM | 72 | hr | 3 | 2461 | 233 | 0.1323 | 0.1286 | 0.0947 | 0.0918 |
A-375 | Vemurafenib | Trametinib | Saracatinib | 0.1000 | 0.0100 | 0.3160 | uM | 72 | hr | 1 | 1677 | 174 | 0.0893 | 0.0914 | 0.1038 | 0.1080 |
A-375 | Vemurafenib | Trametinib | Saracatinib | 0.1000 | 0.0100 | 0.3160 | uM | 72 | hr | 2 | 1828 | 184 | 0.0977 | 0.0914 | 0.1007 | 0.1080 |
A-375 | Vemurafenib | Trametinib | Saracatinib | 0.1000 | 0.0100 | 0.3160 | uM | 72 | hr | 3 | 1666 | 199 | 0.0871 | 0.0914 | 0.1194 | 0.1080 |
A-375 | Vemurafenib | Trametinib | Saracatinib | 0.1000 | 0.0100 | 1.0000 | uM | 72 | hr | 1 | 1282 | 177 | 0.0656 | 0.0610 | 0.1381 | 0.1316 |
A-375 | Vemurafenib | Trametinib | Saracatinib | 0.1000 | 0.0100 | 1.0000 | uM | 72 | hr | 2 | 1231 | 158 | 0.0637 | 0.0610 | 0.1284 | 0.1316 |
A-375 | Vemurafenib | Trametinib | Saracatinib | 0.1000 | 0.0100 | 1.0000 | uM | 72 | hr | 3 | 1037 | 133 | 0.0537 | 0.0610 | 0.1283 | 0.1316 |
A-375 | Vemurafenib | Trametinib | Saracatinib | 0.1000 | 0.0100 | 3.1600 | uM | 72 | hr | 1 | 1074 | 145 | 0.0552 | 0.0473 | 0.1350 | 0.1511 |
A-375 | Vemurafenib | Trametinib | Saracatinib | 0.1000 | 0.0100 | 3.1600 | uM | 72 | hr | 2 | 927 | 141 | 0.0467 | 0.0473 | 0.1521 | 0.1511 |
A-375 | Vemurafenib | Trametinib | Saracatinib | 0.1000 | 0.0100 | 3.1600 | uM | 72 | hr | 3 | 806 | 134 | 0.0399 | 0.0473 | 0.1663 | 0.1511 |
A-375 | Vemurafenib | Trametinib | Saracatinib | 0.3160 | 0.0316 | 0.0000 | uM | 72 | hr | 1 | 2074 | 218 | 0.1102 | 0.1222 | 0.1051 | 0.1075 |
A-375 | Vemurafenib | Trametinib | Saracatinib | 0.3160 | 0.0316 | 0.0000 | uM | 72 | hr | 2 | 2549 | 285 | 0.1345 | 0.1222 | 0.1118 | 0.1075 |
A-375 | Vemurafenib | Trametinib | Saracatinib | 0.3160 | 0.0316 | 0.0000 | uM | 72 | hr | 3 | 2295 | 242 | 0.1219 | 0.1222 | 0.1054 | 0.1075 |
A-375 | Vemurafenib | Trametinib | Saracatinib | 0.3160 | 0.0316 | 0.3160 | uM | 72 | hr | 1 | 1508 | 137 | 0.0814 | 0.0866 | 0.0908 | 0.1048 |
A-375 | Vemurafenib | Trametinib | Saracatinib | 0.3160 | 0.0316 | 0.3160 | uM | 72 | hr | 2 | 1534 | 179 | 0.0805 | 0.0866 | 0.1167 | 0.1048 |
A-375 | Vemurafenib | Trametinib | Saracatinib | 0.3160 | 0.0316 | 0.3160 | uM | 72 | hr | 3 | 1846 | 197 | 0.0979 | 0.0866 | 0.1067 | 0.1048 |
A-375 | Vemurafenib | Trametinib | Saracatinib | 0.3160 | 0.0316 | 1.0000 | uM | 72 | hr | 1 | 1342 | 176 | 0.0693 | 0.0610 | 0.1311 | 0.1313 |
A-375 | Vemurafenib | Trametinib | Saracatinib | 0.3160 | 0.0316 | 1.0000 | uM | 72 | hr | 2 | 1243 | 144 | 0.0653 | 0.0610 | 0.1158 | 0.1313 |
A-375 | Vemurafenib | Trametinib | Saracatinib | 0.3160 | 0.0316 | 1.0000 | uM | 72 | hr | 3 | 959 | 141 | 0.0486 | 0.0610 | 0.1470 | 0.1313 |
A-375 | Vemurafenib | Trametinib | Saracatinib | 0.3160 | 0.0316 | 3.1600 | uM | 72 | hr | 1 | 913 | 154 | 0.0451 | 0.0422 | 0.1687 | 0.1591 |
A-375 | Vemurafenib | Trametinib | Saracatinib | 0.3160 | 0.0316 | 3.1600 | uM | 72 | hr | 2 | 817 | 124 | 0.0412 | 0.0422 | 0.1518 | 0.1591 |