Viability and apoptosis measured by imaging in BRAF(V600E/D) melanoma cell lines following treatment with combinations of three compounds (viability/apoptosis dataset 2 of 2) - Dataset (ID:20273)

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Cell Small Molecule 1 Small Molecule 2 Small Molecule 3 Small Mol 1 Concentration Small Mol 2 Concentration Small Mol 3 Concentration Small Mol Conc Unit Time Point Time Point Unit Replicate Total Number of Cells (Nuclei) Number of Apoptotic Cells Relative Viability Mean Relative Viability Apoptosis Fraction Mean Apoptosis Fraction
COLO 858 Vemurafenib Trametinib PF562271 0.1000 0.0100 1.0000
uM
 72
hr
 3 641 523 0.0230 0.0246 0.8159 0.8210
COLO 858 Vemurafenib Trametinib PF562271 0.1000 0.0100 3.1600
uM
 72
hr
 1 757 701 0.0109 0.0100 0.9260 0.9220
COLO 858 Vemurafenib Trametinib PF562271 0.1000 0.0100 3.1600
uM
 72
hr
 2 649 610 0.0076 0.0100 0.9399 0.9220
COLO 858 Vemurafenib Trametinib PF562271 0.1000 0.0100 3.1600
uM
 72
hr
 3 590 531 0.0115 0.0100 0.9000 0.9220
COLO 858 Vemurafenib Trametinib PF562271 0.3160 0.0316 0.0000
uM
 72
hr
 1 1098 711 0.0754 0.0780 0.6475 0.6507
COLO 858 Vemurafenib Trametinib PF562271 0.3160 0.0316 0.0000
uM
 72
hr
 2 1244 835 0.0796 0.0780 0.6712 0.6507
COLO 858 Vemurafenib Trametinib PF562271 0.3160 0.0316 0.0000
uM
 72
hr
 3 1107 701 0.0791 0.0780 0.6332 0.6507
COLO 858 Vemurafenib Trametinib PF562271 0.3160 0.0316 0.3160
uM
 72
hr
 1 930 774 0.0304 0.0311 0.8323 0.8371
COLO 858 Vemurafenib Trametinib PF562271 0.3160 0.0316 0.3160
uM
 72
hr
 2 966 821 0.0282 0.0311 0.8499 0.8371
COLO 858 Vemurafenib Trametinib PF562271 0.3160 0.0316 0.3160
uM
 72
hr
 3 1042 864 0.0347 0.0311 0.8292 0.8371
COLO 858 Vemurafenib Trametinib PF562271 0.3160 0.0316 1.0000
uM
 72
hr
 1 831 716 0.0224 0.0212 0.8616 0.8626
COLO 858 Vemurafenib Trametinib PF562271 0.3160 0.0316 1.0000
uM
 72
hr
 2 822 698 0.0241 0.0212 0.8491 0.8626
COLO 858 Vemurafenib Trametinib PF562271 0.3160 0.0316 1.0000
uM
 72
hr
 3 716 628 0.0171 0.0212 0.8771 0.8626
COLO 858 Vemurafenib Trametinib PF562271 0.3160 0.0316 3.1600
uM
 72
hr
 1 483 442 0.0080 0.0074 0.9151 0.9225
COLO 858 Vemurafenib Trametinib PF562271 0.3160 0.0316 3.1600
uM
 72
hr
 2 481 450 0.0060 0.0074 0.9356 0.9225
COLO 858 Vemurafenib Trametinib PF562271 0.3160 0.0316 3.1600
uM
 72
hr
 3 505 463 0.0082 0.0074 0.9168 0.9225
COLO 858 Vemurafenib Trametinib PF562271 1.0000 0.1000 0.0000
uM
 72
hr
 1 1025 747 0.0541 0.0539 0.7288 0.7310
COLO 858 Vemurafenib Trametinib PF562271 1.0000 0.1000 0.0000
uM
 72
hr
 2 961 720 0.0469 0.0539 0.7492 0.7310
COLO 858 Vemurafenib Trametinib PF562271 1.0000 0.1000 0.0000
uM
 72
hr
 3 1095 783 0.0608 0.0539 0.7151 0.7310
COLO 858 Vemurafenib Trametinib PF562271 1.0000 0.1000 0.3160
uM
 72
hr
 1 828 729 0.0193 0.0182 0.8804 0.8649
COLO 858 Vemurafenib Trametinib PF562271 1.0000 0.1000 0.3160
uM
 72
hr
 2 606 506 0.0195 0.0182 0.8350 0.8649
COLO 858 Vemurafenib Trametinib PF562271 1.0000 0.1000 0.3160
uM
 72
hr
 3 680 598 0.0160 0.0182 0.8794 0.8649
COLO 858 Vemurafenib Trametinib PF562271 1.0000 0.1000 1.0000
uM
 72
hr
 1 1154 1069 0.0166 0.0145 0.9263 0.9198
COLO 858 Vemurafenib Trametinib PF562271 1.0000 0.1000 1.0000
uM
 72
hr
 2 877 801 0.0148 0.0145 0.9133 0.9198
COLO 858 Vemurafenib Trametinib PF562271 1.0000 0.1000 1.0000
uM
 72
hr
 3 773 711 0.0121 0.0145 0.9198 0.9198