Viability and apoptosis measured by imaging in BRAF(V600E/D) melanoma cell lines following treatment with combinations of three compounds (viability/apoptosis dataset 2 of 2) - Dataset (ID:20273)

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Cell Small Molecule 1 Small Molecule 2 Small Molecule 3 Small Mol 1 Concentration Small Mol 2 Concentration Small Mol 3 Concentration Small Mol Conc Unit Time Point Time Point Unit Replicate Total Number of Cells (Nuclei) Number of Apoptotic Cells Relative Viability Mean Relative Viability Apoptosis Fraction Mean Apoptosis Fraction
A-375 Vemurafenib Trametinib PF562271 1.0000 0.1000 3.1600
uM
 72
hr
 1 994 279 0.0359 0.0344 0.2807 0.2734
A-375 Vemurafenib Trametinib PF562271 1.0000 0.1000 3.1600
uM
 72
hr
 2 983 257 0.0365 0.0344 0.2614 0.2734
A-375 Vemurafenib Trametinib PF562271 1.0000 0.1000 3.1600
uM
 72
hr
 3 849 236 0.0308 0.0344 0.2780 0.2734
A-375 Vemurafenib Trametinib PF562271 3.1600 0.3160 0.0000
uM
 72
hr
 1 2793 297 0.1254 0.1292 0.1063 0.1109
A-375 Vemurafenib Trametinib PF562271 3.1600 0.3160 0.0000
uM
 72
hr
 2 2857 325 0.1272 0.1292 0.1138 0.1109
A-375 Vemurafenib Trametinib PF562271 3.1600 0.3160 0.0000
uM
 72
hr
 3 3028 341 0.1350 0.1292 0.1126 0.1109
A-375 Vemurafenib Trametinib PF562271 3.1600 0.3160 0.3160
uM
 72
hr
 1 2412 298 0.1062 0.1004 0.1235 0.1324
A-375 Vemurafenib Trametinib PF562271 3.1600 0.3160 0.3160
uM
 72
hr
 2 2243 306 0.0973 0.1004 0.1364 0.1324
A-375 Vemurafenib Trametinib PF562271 3.1600 0.3160 0.3160
uM
 72
hr
 3 2254 309 0.0977 0.1004 0.1371 0.1324
A-375 Vemurafenib Trametinib PF562271 3.1600 0.3160 1.0000
uM
 72
hr
 1 2244 392 0.0931 0.0785 0.1747 0.1769
A-375 Vemurafenib Trametinib PF562271 3.1600 0.3160 1.0000
uM
 72
hr
 2 1867 342 0.0766 0.0785 0.1832 0.1769
A-375 Vemurafenib Trametinib PF562271 3.1600 0.3160 1.0000
uM
 72
hr
 3 1586 274 0.0659 0.0785 0.1728 0.1769
A-375 Vemurafenib Trametinib PF562271 3.1600 0.3160 3.1600
uM
 72
hr
 1 963 266 0.0350 0.0308 0.2762 0.3011
A-375 Vemurafenib Trametinib PF562271 3.1600 0.3160 3.1600
uM
 72
hr
 2 898 274 0.0314 0.0308 0.3051 0.3011
A-375 Vemurafenib Trametinib PF562271 3.1600 0.3160 3.1600
uM
 72
hr
 3 764 246 0.0260 0.0308 0.3220 0.3011
A-375 Vemurafenib Trametinib Saracatinib 0.0000 0.0000 0.0000
uM
 72
hr
 1 18392 833 1.0430 1.0000 0.0453 0.0438
A-375 Vemurafenib Trametinib Saracatinib 0.0000 0.0000 0.0000
uM
 72
hr
 2 18289 776 1.0403 1.0000 0.0424 0.0438
A-375 Vemurafenib Trametinib Saracatinib 0.0000 0.0000 0.0000
uM
 72
hr
 3 16139 705 0.9168 1.0000 0.0437 0.0438
A-375 Vemurafenib Trametinib Saracatinib 0.0000 0.0000 0.3160
uM
 72
hr
 1 13521 729 0.7598 0.8466 0.0539 0.0510
A-375 Vemurafenib Trametinib Saracatinib 0.0000 0.0000 0.3160
uM
 72
hr
 2 15518 786 0.8751 0.8466 0.0507 0.0510
A-375 Vemurafenib Trametinib Saracatinib 0.0000 0.0000 0.3160
uM
 72
hr
 3 16012 776 0.9050 0.8466 0.0485 0.0510
A-375 Vemurafenib Trametinib Saracatinib 0.0000 0.0000 1.0000
uM
 72
hr
 1 9338 344 0.5342 0.4663 0.0368 0.0378
A-375 Vemurafenib Trametinib Saracatinib 0.0000 0.0000 1.0000
uM
 72
hr
 2 7768 292 0.4441 0.4663 0.0376 0.0378
A-375 Vemurafenib Trametinib Saracatinib 0.0000 0.0000 1.0000
uM
 72
hr
 3 7367 288 0.4205 0.4663 0.0391 0.0378
A-375 Vemurafenib Trametinib Saracatinib 0.0000 0.0000 3.1600
uM
 72
hr
 1 8961 339 0.5121 0.3895 0.0378 0.0403