Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 2 of 4: Calculated dose-response metrics. - Dataset (ID:20269)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Biological Replicate ID | Conc Unit | GR50 | GEC50 | GRmax | GRinf | GR Hill Coefficient | GR_AOC | GR r2 | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| T47D | HR+ | Luminal | JNK-IN-5A | JNK | JNK | 10939.144 | uM | inf | 1.74480 | 0.7037 | 0.5944 | 5.0000 | 0.1649 | 0.6918 | 1.7115 | |
| T47D | HR+ | Luminal | L-779450 | BRAF | MAPK | 10939.149 | uM | 54.8250 | 169.08180 | 0.6524 | -1.0000 | 0.9755 | 0.0447 | 0.8546 | 1.6748 | |
| T47D | HR+ | Luminal | Lapatinib | EGFR/HER2 | ErbB | 7542.098 | uM | inf | inf | 0.8795 | 0.8795 | 0.0000 | 0.0581 | 0.3506 | 1.3028 | |
| T47D | HR+ | Luminal | Lapatinib | EGFR/HER2 | ErbB | 7543.098 | uM | 20.11450 | 203.00510 | 0.5244 | -0.9885 | 0.4719 | 0.0825 | 0.9429 | 1.4503 | |
| T47D | HR+ | Luminal | LBH589 | HDAC | HDAC | 10939.154 | uM | 0.14898 | 0.21568 | -0.8220 | -0.8250 | 2.6339 | 0.7328 | 0.9977 | 1.6876 | |
| T47D | HR+ | Luminal | Lestaurtinib | FLT3/JAK2/TrkA | RTK | 10939.154 | uM | 5.8580 | 7.98810 | -0.2938 | -0.3864 | 1.8462 | 0.1727 | 0.9913 | 1.6876 | |
| T47D | HR+ | Luminal | Mebendazole | 12720.174 | uM | 1.95370 | 2.63220 | 0.0705 | -0.0807 | 0.5022 | 0.3129 | 0.9423 | 0.9688 | |||
| T47D | HR+ | Luminal | Methotrexate | DHFR | Metabolism | 7543.084 | uM | inf | inf | 0.9681 | 0.9681 | 0.0000 | -0.0288 | -0.6533 | 1.3431 | |
| T47D | HR+ | Luminal | Methylglyoxal | 13623.184 | uM | 575.5230 | 599.38190 | -0.7988 | -0.1126 | 5.0000 | 0.5014 | 0.5757 | 1.1220 | |||
| T47D | HR+ | Luminal | MG-132 | Proteasome | Proteasome | 14293.189 | uM | inf | inf | 1.0500 | 1.0500 | 0.0000 | 0.0506 | 0.1193 | 0.6707 | |
| T47D | HR+ | Luminal | MG-132 | Proteasome | Proteasome | 14293.189 | uM | inf | inf | 1.0500 | 1.0500 | 0.0000 | 0.0506 | 0.1193 | 0.6707 | |
| T47D | HR+ | Luminal | MG-132 | Proteasome | Proteasome | 14179.189 | uM | 0.13802 | 0.15762 | -0.9999 | -0.4713 | 5.0000 | 0.7615 | 0.6237 | 0.4365 | |
| T47D | HR+ | Luminal | MG-132 | Proteasome | Proteasome | 14179.189 | uM | 0.13802 | 0.15762 | -0.9999 | -0.4713 | 5.0000 | 0.7615 | 0.6237 | 0.4365 | |
| T47D | HR+ | Luminal | MG-132 | Proteasome | Proteasome | 10939.145 | uM | 0.11495 | 0.15659 | -0.8571 | -0.8473 | 3.2066 | 0.8684 | 0.9991 | 1.6558 | |
| T47D | HR+ | Luminal | MG-132 | Proteasome | Proteasome | 10939.145 | uM | 0.11495 | 0.15659 | -0.8571 | -0.8473 | 3.2066 | 0.8684 | 0.9991 | 1.6558 | |
| T47D | HR+ | Luminal | Pevonedistat | NAE1 | NAE1 | 10939.148 | uM | 0.13948 | 0.11089 | 0.3318 | 0.3412 | 5.0000 | 0.3414 | 0.970 | 1.6568 | |
| T47D | HR+ | Luminal | Nelfinavir | 12720.174 | uM | 11.06050 | 19.68030 | -0.4660 | -1.0000 | 1.9065 | 0.1951 | 0.9590 | 0.9688 | |||
| T47D | HR+ | Luminal | Nilotinib | ABL | nRTK | 10939.145 | uM | inf | inf | 1.0032 | 1.0032 | 0.0000 | 0.0254 | 0.0000 | 1.6558 | |
| T47D | HR+ | Luminal | NSC 663284 | CDC25 | CDC | 10939.152 | uM | 6.51840 | 8.92360 | -0.8797 | -0.8828 | 3.2388 | 0.4375 | 0.9984 | 1.6952 | |
| T47D | HR+ | Luminal | NU6102 | CDK1/2 | CDK | 10939.147 | uM | 30.55190 | 82.88550 | 0.1187 | -0.9998 | 1.1007 | 0.1169 | 0.9784 | 1.7195 | |
| T47D | HR+ | Luminal | Nutlin 3a | MDM2 | MDM2 | 7542.066 | uM | 28.54290 | 215.66510 | 0.2738 | -1.0000 | 0.5432 | 0.1613 | 0.8935 | 1.0766 | |
| T47D | HR+ | Luminal | Nutlin 3a | MDM2 | MDM2 | 7543.066 | uM | 26.78580 | 62.31150 | -0.0557 | -1.0000 | 1.3013 | 0.1682 | 0.9164 | 1.4960 | |
| T47D | HR+ | Luminal | Olomoucine II | CDK1 | CDK | 10939.147 | uM | 6.5960 | 5.64870 | 0.2284 | 0.2697 | 4.9998 | 0.1919 | 0.9732 | 1.7195 | |
| T47D | HR+ | Luminal | Omipalisib | PI3K | PI3K | 7542.086 | uM | 0.00360 | 0.00826 | -0.6357 | -0.5070 | 0.8440 | 0.9489 | 0.9855 | 1.0375 | |
| T47D | HR+ | Luminal | Oxaliplatin | DNA cross-linker | DNA cross-linker | 9897.021 | uM | 1.67590 | 5.44270 | -0.9725 | -0.9186 | 0.8853 | 0.6867 | 0.9909 | 0.6103 |