Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 2 of 4: Calculated dose-response metrics. - Dataset (ID:20269)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Biological Replicate ID | Conc Unit | GR50 | GEC50 | GRmax | GRinf | GR Hill Coefficient | GR_AOC | GR r2 | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| T47D | HR+ | Luminal | Bortezomib | Proteasome | Proteasome | 7542.074 | uM | 0.06072 | 0.08408 | -0.9251 | -0.9354 | 3.2395 | 1.1458 | 0.9975 | 1.4673 | |
| T47D | HR+ | Luminal | Bortezomib | Proteasome | Proteasome | 7542.074 | uM | 0.06072 | 0.08408 | -0.9251 | -0.9354 | 3.2395 | 1.1458 | 0.9975 | 1.4673 | |
| T47D | HR+ | Luminal | Bortezomib | Proteasome | Proteasome | 14924.203 | uM | 0.00405 | 0.00616 | -0.9568 | -0.9655 | 2.5587 | 1.4202 | 0.9993 | 1.0024 | |
| T47D | HR+ | Luminal | Bortezomib | Proteasome | Proteasome | 14924.203 | uM | 0.00405 | 0.00616 | -0.9568 | -0.9655 | 2.5587 | 1.4202 | 0.9993 | 1.0024 | |
| T47D | HR+ | Luminal | Bortezomib | Proteasome | Proteasome | 15340.203 | uM | 0.00373 | 0.00642 | -0.9095 | -0.9143 | 1.9126 | 1.3715 | 0.9998 | 1.4449 | |
| T47D | HR+ | Luminal | Bortezomib | Proteasome | Proteasome | 15340.203 | uM | 0.00373 | 0.00642 | -0.9095 | -0.9143 | 1.9126 | 1.3715 | 0.9998 | 1.4449 | |
| T47D | HR+ | Luminal | Bortezomib | Proteasome | Proteasome | 7543.074 | uM | 0.03977 | 0.05443 | -0.9846 | -0.9913 | 3.4830 | 1.2465 | 0.9998 | 1.2642 | |
| T47D | HR+ | Luminal | Bortezomib | Proteasome | Proteasome | 7543.074 | uM | 0.03977 | 0.05443 | -0.9846 | -0.9913 | 3.4830 | 1.2465 | 0.9998 | 1.2642 | |
| T47D | HR+ | Luminal | Bosutinib | Src | nRTK | 10939.145 | uM | 4.94280 | 5.39290 | -0.7146 | -0.2731 | 5.0000 | 0.3121 | 0.8541 | 1.6558 | |
| T47D | HR+ | Luminal | Carboplatin | DNA cross-linker | DNA cross-linker | 9897.021 | uM | 45.86870 | 163.27360 | -0.7595 | -1.0000 | 0.8653 | 0.3240 | 0.9854 | 0.6103 | |
| T47D | HR+ | Luminal | Carboplatin | DNA cross-linker | DNA cross-linker | 9033.075 | uM | 164.11960 | 521.80410 | -0.4269 | -1.0000 | 0.9498 | 0.2156 | 0.9975 | 0.9560 | |
| T47D | HR+ | Luminal | Cetuximab | EGFR | ErbB | 9033.018 | uM | inf | inf | 1.0500 | 1.0500 | 0.0000 | -0.0181 | -0.2772 | 0.8708 | |
| T47D | HR+ | Luminal | CGC-11047 | Polyamine analogue | 9897.034 | uM | 0.09833 | 5.57170 | -0.9954 | -1.0000 | 0.2721 | 1.0422 | 0.8289 | 0.3940 | ||
| T47D | HR+ | Luminal | CGC-11047 | Polyamine analogue | 9033.018 | uM | 5.17160 | 88.470 | -0.9313 | -1.0000 | 0.3869 | 0.7123 | 0.9322 | 0.8708 | ||
| T47D | HR+ | Luminal | Cisplatin | DNA cross-linker | DNA cross-linker | 9897.021 | uM | 4.86830 | 12.86690 | -0.6875 | -0.7725 | 0.9612 | 0.4229 | 0.9913 | 0.6103 | |
| T47D | HR+ | Luminal | CPT-11 | TOP1 | TOP | 9897.034 | uM | 0.49263 | 0.95061 | -0.7852 | -0.6884 | 1.3170 | 0.5463 | 0.9875 | 0.3940 | |
| T47D | HR+ | Luminal | Dactolisib | PI3K | PI3K | 10939.155 | uM | 0.28256 | 0.10664 | 0.5293 | 0.4077 | 1.7334 | 0.2810 | 0.7565 | 1.5150 | |
| T47D | HR+ | Luminal | Dichloroacetate | PDK | PDK | 12720.176 | uM | inf | inf | 0.7642 | 0.7642 | 0.0000 | 0.0942 | 0.3639 | 0.9483 | |
| T47D | HR+ | Luminal | Disulfiram | Proteasome | Proteasome | 12720.174 | uM | 0.07184 | 0.04876 | 0.5221 | 0.3686 | 3.4495 | 0.3969 | 0.7042 | 0.9688 | |
| T47D | HR+ | Luminal | Docetaxel | TUBB | TUBB | 9897.002 | uM | 0.00256 | 0.00296 | -0.5189 | -0.5430 | 4.9999 | 0.9824 | 0.9806 | 0.4068 | |
| T47D | HR+ | Luminal | Docetaxel | TUBB | TUBB | 12720.002 | uM | 0.00331 | 0.00322 | 0.0504 | 0.0506 | 4.0004 | 0.5785 | 0.9948 | 1.0368 | |
| T47D | HR+ | Luminal | Doxorubicin | TOP2 | TOP | 9897.034 | uM | 0.02730 | 0.05890 | -0.9992 | -0.8255 | 1.2678 | 1.0020 | 0.9728 | 0.3940 | |
| T47D | HR+ | Luminal | Erlotinib | EGFR | ErbB | 7542.092 | uM | inf | inf | 0.7345 | 0.7345 | 0.0000 | 0.0601 | 0.5389 | 1.5380 | |
| T47D | HR+ | Luminal | Erlotinib | EGFR | ErbB | 7543.091 | uM | 293.83880 | 999.39880 | 0.6798 | -0.3849 | 0.4663 | 0.0720 | 0.9005 | 1.4781 | |
| T47D | HR+ | Luminal | Etoposide | TOP2 | TOP | 7542.074 | uM | 0.82365 | 1.1640 | -0.2845 | -0.2789 | 1.2815 | 0.5747 | 0.9947 | 1.4673 |