Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 2 of 4: Calculated dose-response metrics. - Dataset (ID:20269)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Biological Replicate ID | Conc Unit | GR50 | GEC50 | GRmax | GRinf | GR Hill Coefficient | GR_AOC | GR r2 | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| MX1 | Unknown | Unknown | Bosutinib | Src | nRTK | 10874.145 | uM | 1.43740 | 5.69250 | -0.6805 | -0.9193 | 0.7581 | 0.4423 | 0.9637 | 0.8505 | |
| MX1 | Unknown | Unknown | Celecoxib | COX2 | COX | 10644.136 | uM | 23.48360 | 26.10660 | -0.9077 | -0.3445 | 4.9495 | 0.3623 | 0.7525 | 0.5562 | |
| MX1 | Unknown | Unknown | FTase Inhibitor I | Ftase | MAPK | 10644.142 | uM | inf | inf | 0.7386 | 0.7386 | 0.0000 | 0.0345 | 0.4867 | 0.5163 | |
| MX1 | Unknown | Unknown | Erlotinib | EGFR | ErbB | 7523.091 | uM | 5.14080 | 33.22490 | -0.2637 | -1.0000 | 0.5887 | 0.3002 | 0.9420 | 0.9283 | |
| MX1 | Unknown | Unknown | FR180204 | ERK1/2 | MAPK | 10874.149 | uM | inf | inf | 0.9293 | 0.9293 | 0.0000 | 0.0534 | 0.0000 | 0.8239 | |
| MX1 | Unknown | Unknown | MG-132 | Proteasome | Proteasome | 10644.145 | uM | 0.04734 | 0.07256 | -1.0000 | -1.0000 | 2.5730 | 1.0527 | 0.9991 | 0.4300 | |
| MX1 | Unknown | Unknown | GW843682X | PLK | PLK | 10644.139 | uM | inf | inf | 0.8049 | 0.8049 | 0.0000 | 0.0886 | 0.2257 | 0.6077 | |
| MX1 | Unknown | Unknown | Ibandronate | FDPS | 12220.143 | uM | 51.18350 | 329.6960 | -0.5371 | -1.0000 | 0.5898 | 0.4324 | 0.6251 | 0.4532 | ||
| MX1 | Unknown | Unknown | MG-132 | Proteasome | Proteasome | 14278.189 | uM | inf | inf | -0.9921 | -0.9921 | 0.0000 | 0.7370 | 0.5547 | 0.7296 | |
| MX1 | Unknown | Unknown | Valproic acid | HDAC | HDAC | 10644.143 | uM | 355.22210 | 734.46760 | -0.9986 | -1.0000 | 1.5124 | 0.6015 | 0.9444 | 0.6221 | |
| MX1 | Unknown | Unknown | Pemetrexed | TYMS/DHFR/GARFT | TYMS | 7523.095 | uM | inf | 0.22243 | 0.4987 | 0.5629 | 2.6377 | 0.3218 | 0.9364 | 0.8203 | |
| MX1 | Unknown | Unknown | NU6102 | CDK1/2 | CDK | 10874.147 | uM | 8.77790 | 15.5340 | -0.9506 | -1.0000 | 1.9247 | 0.2286 | 0.9925 | 0.7482 | |
| MX1 | Unknown | Unknown | Nelfinavir | 12667.174 | uM | 6.93420 | 10.10980 | -0.9543 | -1.0000 | 2.9138 | 0.1831 | 0.990 | 0.8129 | |||
| MX1 | Unknown | Unknown | NSC 663284 | CDC25 | CDC | 10644.14 | uM | 0.66207 | 0.82476 | -1.0000 | -1.0000 | 5.0000 | 0.8690 | 0.9955 | 0.4302 | |
| MX1 | Unknown | Unknown | PD184352 | MEK | MAPK | 10874.155 | uM | 13.13740 | 85.26950 | 0.2694 | -1.0000 | 0.5874 | 0.1658 | 0.8268 | 0.8099 | |
| MX1 | Unknown | Unknown | Nutlin 3a | MDM2 | MDM2 | 7523.066 | uM | 18.27720 | 28.530 | -0.7868 | -1.0000 | 2.4671 | 0.2462 | 0.9331 | 0.8127 | |
| MX1 | Unknown | Unknown | PD 98059 | MEK | MAPK | 10644.136 | uM | 80.20970 | 150.0160 | 0.3780 | -0.7441 | 1.4559 | 0.0899 | 0.6828 | 0.5562 | |
| MX1 | Unknown | Unknown | Selumetinib | MEK | MAPK | 10874.155 | uM | 0.39717 | 0.94112 | -0.4198 | -0.4296 | 0.7188 | 0.4271 | 0.9765 | 0.8099 | |
| MX1 | Unknown | Unknown | PS-1145 | IKK | NFKB | 7523.065 | uM | inf | inf | 1.0500 | 1.0500 | 0.0000 | -0.0407 | -9.0127 | 0.7668 | |
| MX1 | Unknown | Unknown | Selumetinib | MEK | MAPK | 12220.155 | uM | 0.02993 | 0.55898 | -0.6163 | -1.0000 | 0.3753 | 0.7675 | 0.9750 | 0.4858 | |
| MX1 | Unknown | Unknown | Temsirolimus | MTOR | MTOR | 12220.144 | uM | 0.02360 | 0.77539 | -0.9859 | -1.0000 | 0.3146 | 0.8616 | 0.8928 | 0.5126 | |
| MX1 | Unknown | Unknown | Sirolimus | MTOR | MTOR | 7523.069 | uM | 1.62940 | 997.53050 | 0.1017 | -0.9381 | 0.1646 | 0.3406 | 0.6845 | 0.9585 | |
| MX1 | Unknown | Unknown | Sulindac sulfide | COX1/2 | COX | 10644.136 | uM | 46.36640 | 59.40490 | -0.7288 | -0.8049 | 3.8711 | 0.1583 | 0.9517 | 0.5562 |