Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 2 of 4: Calculated dose-response metrics. - Dataset (ID:20269)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Biological Replicate ID | Conc Unit | GR50 | GEC50 | GRmax | GRinf | GR Hill Coefficient | GR_AOC | GR r2 | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| HCC38 | TNBC | Basal B | 5-FU | TYMS | TYMS | 9469.131 | uM | 492.70010 | 1000.00000 | -0.6025 | -0.6339 | 1.1567 | 0.3652 | 0.9907 | 1.0627 | |
| MDA-MB-361 | HER2amp | Luminal | 5-FU | TYMS | TYMS | 9648.017 | uM | 73.7610 | 272.01450 | -0.9821 | -1.0000 | 0.8418 | 0.6700 | 0.9889 | 0.5727 | |
| SUM1315MO2 | TNBC | Basal B | 5-FU | TYMS | TYMS | 9797.017 | uM | 294.50090 | 1000.00000 | -0.7827 | -0.9123 | 0.8494 | 0.4993 | 0.9479 | 0.4824 | |
| HCC1187 | TNBC | Basal A | 5-FU | TYMS | TYMS | 7812.017 | uM | 505.4030 | 1000.00000 | -0.8283 | -0.6532 | 1.2246 | 0.3272 | 0.9679 | 1.1362 | |
| HCC1954 | HER2amp | Basal A | 5-FU | TYMS | TYMS | 9386.017 | uM | 16.03030 | 95.80030 | -0.6011 | -0.7103 | 0.4945 | 0.7125 | 0.9944 | 1.3666 | |
| HCC1395 | TNBC | Basal B | 5-FU | TYMS | TYMS | 7816.017 | uM | 5569.35590 | 1000.00000 | 0.3951 | 0.3058 | 0.5506 | 0.1699 | 0.9805 | 1.2318 | |
| SK-BR-3 | HER2amp | Luminal | 5-FU | TYMS | TYMS | 9760.131 | uM | 18.3860 | 1000.00000 | -0.4736 | -0.9151 | 0.2603 | 0.6203 | 0.8050 | 0.9878 | |
| HCC1395 | TNBC | Basal B | 5-FU | TYMS | TYMS | 9258.03 | uM | 607.47860 | 1000.00000 | -0.8573 | -0.7154 | 1.7821 | 0.3361 | 0.9845 | 0.4015 | |
| HCC1954 | HER2amp | Basal A | 5-FU | TYMS | TYMS | 7837.017 | uM | 21.57250 | 63.96340 | -0.5669 | -0.5580 | 0.6896 | 0.6860 | 0.9915 | 1.4255 | |
| HCC1419 | HER2amp | Luminal | 5-FU | TYMS | TYMS | 7820.017 | uM | 127.9330 | 620.18530 | -0.7617 | -0.9506 | 0.6748 | 0.5583 | 0.9859 | 0.6915 | |
| HCC1419 | HER2amp | Luminal | 5-FU | TYMS | TYMS | 7821.017 | uM | 232.84290 | 534.85860 | -0.8970 | -0.8996 | 1.2377 | 0.4969 | 0.9956 | 0.3792 | |
| Hs 578T | TNBC | Basal B | 5-FU | TYMS | TYMS | 7864.017 | uM | 56.13570 | 165.52520 | -0.5570 | -0.6452 | 0.7664 | 0.6230 | 0.9857 | 1.6561 | |
| MCF 10A | NM | Basal B | 5-FU | TYMS | TYMS | 7870.017 | uM | 30.5580 | 107.74890 | -0.8406 | -0.9221 | 0.8295 | 0.7835 | 0.9913 | 2.0447 | |
| AU565 | HER2amp | Luminal | 5-FU | TYMS | TYMS | 7793.035 | uM | 7.14650 | 49.68870 | -0.3950 | -0.5513 | 0.3832 | 0.7305 | 0.9781 | 1.2119 | |
| AU565 | HER2amp | Luminal | 5-FU | TYMS | TYMS | 9035.017 | uM | 234.20810 | 255.89090 | 0.0352 | -0.0320 | 0.6997 | 0.3489 | 0.9930 | 2.2905 | |
| MDA-MB-175-VII | HR+ | Luminal | 5-FU | TYMS | TYMS | 7886.017 | uM | 133.62210 | 479.01180 | -0.8971 | -1.0000 | 0.8605 | 0.5873 | 0.9930 | 0.7230 | |
| MDA-MB-134-VI | HR+ | Luminal | 5-FU | TYMS | TYMS | 7876.017 | uM | 24.33680 | 434.4740 | -0.7133 | -1.0000 | 0.3812 | 0.6725 | 0.9013 | 0.6706 | |
| HMT-3522 S1 | Unknown | Unknown | 5-FU | TYMS | TYMS | 7911.017 | uM | 171.27690 | 862.56090 | -0.4058 | -0.7064 | 0.5448 | 0.4588 | 0.9804 | 1.6151 | |
| MDA-MB-175-VII | HR+ | Luminal | 5-FU | TYMS | TYMS | 7885.017 | uM | 68.30750 | 288.83820 | -0.9570 | -1.0000 | 0.7620 | 0.6648 | 0.9889 | 0.5647 | |
| HCC1937 | TNBC | Basal A | 5-FU | TYMS | TYMS | 7833.017 | uM | inf | 64.04740 | 0.5456 | 0.5777 | 0.9955 | 0.1862 | 0.9796 | 1.2975 | |
| HCC1143 | TNBC | Basal A | 5-FU | TYMS | TYMS | 7810.017 | uM | 79.51050 | 198.63970 | -0.3272 | -0.3499 | 0.5794 | 0.4638 | 0.9680 | 0.8986 | |
| HCC1937 | TNBC | Basal A | 5-FU | TYMS | TYMS | 7832.017 | uM | 188.21880 | 755.07660 | -0.3109 | -0.5336 | 0.5227 | 0.4176 | 0.9972 | 1.3404 | |
| HCC1143 | TNBC | Basal A | 5-FU | TYMS | TYMS | 7809.017 | uM | 623.11290 | 167.76560 | 0.2797 | 0.2268 | 0.4605 | 0.3087 | 0.9302 | 1.7591 | |
| MDA-MB-231 | TNBC | Basal B | 5-FU | TYMS | TYMS | 7892.017 | uM | 389.45810 | 1000.00000 | -0.0878 | -0.3037 | 0.5033 | 0.3259 | 0.9883 | 2.4495 | |
| HCC1937 | TNBC | Basal A | 5-FU | TYMS | TYMS | 7834.13 | uM | 453.5720 | 570.59710 | 0.0562 | -0.0678 | 0.5542 | 0.3087 | 0.9979 | 1.9535 |